An Unexpected Discovery in the Rich Open Cluster NGC 6819 Using XMM-Newton

We present the first study of the X-ray population of the intermediate-age rich open cluster NGC 6819 using the XMM-Newton Observatory. In the past decade, Chandra X-ray observations have shown a relationship between the X-ray population of globular clusters and their internal dynamics and encounter frequency. We investigate the role dynamics possibly play in the formation of X-ray sources in NGC 6819, and compare our results with known properties of field and globular cluster X-ray populations. We implement a multi wavelength approach to studying the X-ray sources, utilizing X-ray and UV data from XMM observations along with the wealth of photometry and radial-velocity data from the WIYN Open Cluster Study (WOCS) and the CFHT Open Cluster Survey. Within the cluster half-light radius we detect 12 X-ray sources down to a luminosity of 10^30 erg/s for cluster members. The sources include a candidate quiescent low-mass X-ray binary (qLMXB), a candidate cataclysmic variable, and two active binary systems. The presence of a qLMXB in an open cluster is previously unexpected given the known relationships between luminous X-ray sources and encounter frequency in globular clusters, and most likely has a dynamical origin.Comment: 14 pages, 11 figures, accepted for publication in the Astrophysical Journa

Embalmed heads of the Celtic Iron Age in the south of France

Ancient texts described that one of the most impressive ritual practices of the Celts during the Iron Age was to remove the heads of enemies killed in battle and to embalm them for display in front of the victors dwellings. An archaeological settlement excavation site in Le Cailar, in southern France, has revealed a considerable number of examples of this practice. It was documented by Classical authors and later by the archaeological recording of iconographic representations and skeletal remains of human heads. Weapons were also exhibited alongside the severed heads. Here we report the results of chemical investigations for the characterization of the biomarkers of embalming that are likely to be present in eleven fragments of these human cranial remains. These results may lead to answers to some of the archaeometric questions related to the subject of embalming in 3rd century BC Transalpine Gaul, thus advancing the knowledge of these ritual practices, documented by Greek Classical authors as part of the wider research into the proto-historic societies of the Mediterranean coastal region

The Linked Data Benchmark Council (LDBC): Driving competition and collaboration in the graph data management space

Graph data management is instrumental for several use cases such as recommendation, root cause analysis, financial fraud detection, and enterprise knowledge representation. Efficiently supporting these use cases yields a number of unique requirements, including the need for a concise query language and graph-aware query optimization techniques. The goal of the Linked Data Benchmark Council (LDBC) is to design a set of standard benchmarks that capture representative categories of graph data management problems, making the performance of systems comparable and facilitating competition among vendors. LDBC also conducts research on graph schemas and graph query languages. This paper introduces the LDBC organization and its work over the last decade

The Linked Data Benchmark Council (LDBC): Driving competition and collaboration in the graph data management space

Graph data management is instrumental for several use cases such as recommendation, root cause analysis, financial fraud detection, and enterprise knowledge representation. Efficiently supporting these use cases yields a number of unique requirements, including the need for a concise query language and graph-aware query optimization techniques. The goal of the Linked Data Benchmark Council (LDBC) is to design a set of standard benchmarks that capture representative categories of graph data management problems, making the performance of systems comparable and facilitating competition among vendors. LDBC also conducts research on graph schemas and graph query languages. This paper introduces the LDBC organization and its work over the last decade

Updated international tuberous sclerosis complex diagnostic criteria and surveillance and management recommendations

Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease affecting multiple body systems with wide variability in presentation. In 2013, Pediatric Neurology published articles outlining updated diagnostic criteria and recommendations for surveillance and management of disease manifestations. Advances in knowledge and approvals of new therapies necessitated a revision of those criteria and recommendations. Methods Chairs and working group cochairs from the 2012 International TSC Consensus Group were invited to meet face-to-face over two days at the 2018 World TSC Conference on July 25 and 26 in Dallas, TX, USA. Before the meeting, working group cochairs worked with group members via e-mail and telephone to (1) review TSC literature since the 2013 publication, (2) confirm or amend prior recommendations, and (3) provide new recommendations as required. Results Only two changes were made to clinical diagnostic criteria reported in 2013: “multiple cortical tubers and/or radial migration lines” replaced the more general term “cortical dysplasias,” and sclerotic bone lesions were reinstated as a minor criterion. Genetic diagnostic criteria were reaffirmed, including highlighting recent findings that some individuals with TSC are genetically mosaic for variants in TSC1 or TSC2. Changes to surveillance and management criteria largely reflected increased emphasis on early screening for electroencephalographic abnormalities, enhanced surveillance and management of TSC-associated neuropsychiatric disorders, and new medication approvals. Conclusions Updated TSC diagnostic criteria and surveillance and management recommendations presented here should provide an improved framework for optimal care of those living with TSC and their families

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Behaving as a convert : moral teaching in Ephesians against its traditional and social backgrounds.

The study examines Eph 4:1-5:20. Consisting of five chapters, it probes the following five passages: 4:1-16; 4:17-24; 4:25-5:2; 5:3-14; and 5:15-20. Each chapter investigates the relevant verses exegetically, focussing on behavioural aspects. This overview is then compared with issues raised in chapters 1-3, with similar notions of morality from antecedent Pauline writings and with selected Jewish and Graeco Roman writings. The final section of each chapter builds and then applies a social science or social history model. Though exhibiting differences from Paul's undisputed writings, the basic moral view of these verses is Pauline. Various Jewish writings (LXX, Greek versions of OT Pseudepigrapha and relevant passages from Josephus, Philo and Qumran) are brought to bear on these verses. Certain Graeco-Roman writings, (Plato's Laws, Aristotle's Nicornachean Ethics and discourses from Dio Chrysostom and Epictetus) are also examined. Though a remarkable number of affinities exist between Ephesians and these other writings, no evidence of direct influence is detected. Rather, Ephesians appears to be a product of its age, expressing similar ideas because it shares elements of a common world view. Ephesians differs from most of the non-Pauline writings examined by linking morality with religious devotion. Social network and exchange theories (chapter 1), New Religious Movements theories (chapters 2 and 3), principles from honour and shame cultures (chapter 4) and a social model from symposia (chapter 5) were applied to relevant passages. Though historical circumstances behind the letter are unknown, Ephesians' moral teaching portrays human situations. The NRM theory applied in chapters 2 and 3 proved to be particularly helpful in explaining how Ephesians' rejection of gentile immorality (4:17-19) does not contradict its acceptance of gentile social structures