Research of the Additional Losses Occurring in Optical Fiber at its Multiple Bends in the Range Waves 1310nm, 1550nm and 1625nm Long

Article is devoted to research of the additional losses occurring in the optical fiber at its multiple bends in the range waves of 1310 nanometers, 1550 nanometers and 1625 nanometers long. Article is directed on creation of the external factors methods which allow to estimate and eliminate negative influence. The automated way of calculation of losses at a bend is developed. Results of scientific researches are used by engineers of "Kazaktelekom" AS for practical definition of losses service conditions. For modeling the Wolfram|Alpha environment - the knowledge base and a set of computing algorithms was chosen. The greatest losses are noted on wavelength 1310nm and 1625nm. All dependences are nonlinear. Losses with each following excess are multiplicative

ADJUSTMENT OF THRUSTING STRUCTURE IN THE KOVYKTA-KHANDINSKAYA REFLECTED FOLDING ZONE

The Kovykta-Khandinskaya zone, which includes the Kovykta gas condensate field, is a giant located in the junction zone of the Angara-Lena stage with the craton edge – the Cis-Baikal trough. Here, according to the results of long-term geological exploration, the Verkhnelenskoe uplift was identified, the northern part of which is reflected on tectonic maps as the Kovykta ledge. At the same time, the geological model of the field today is based on the standard two-member model, which includes a slightly disturbed sedimentary cover and basement. However, new geophysical studies revealed that the sedimentary cover of the eastern part of the zone is intensely deformed and has a two-tiered nodular-thrust structure (the lower layer is autochthon, the upper layer is allochthon). The main object for gas exploration within the Kovykta gas condensate field is the Vendian formation. The middle (halogen-carbonate) section has been studied fragmentarily, mainly as an object of geological geohazards when drilling deep wells. The involvement of new data from 3D seismic and 3D transient electromagnetic methods made it possible to clarify the Kovykta gas condensate field tectonic structure to assess the potential of secondary carbonate reservoirs characterized by intense fluid (natural gas, brines) inflows

COMPARSION OF NEW METHODS IN PENICILLINACYLASE IMMOBILIZATION

Приведено сравнение эффективности химической и ферментативной технологии производства антибиотиков пенициллинового ряда. Дана оценка некоторым современным методам иммобилизации фермента пенициллина-цилазы. Выбраны наиболее эффективные и ресурсоемкие. Их применение в промышленности позволит повысить производительность и снизить себестоимость конечного продукта.A comparison of the effectiveness of chemical and enzymatic technology for the penicillin antibiotics production is given. Some modern methods of immobilization of the penicillin-cyclase enzyme are evaluated. The most effective and resourceintensive ones were selected. Their application in industry will increase productivity and reduce the self-cost of the final product

Molecular alliance of Lymantria dispar multiple nucleopolyhedrovirus and a short unmodified antisense oligonucleotide of its anti-apoptotic IAP-3 gene: A novel approach for gypsy moth control

Baculovirus IAP (inhibitor-of-apoptosis) genes originated by capture of host genes. Unmodified short antisense DNA oligonucleotides (oligoDNAs) from baculovirus IAP genes can down-regulate specific gene expression profiles in both baculovirus-free and baculovirus-infected insects. In this study, gypsy moth (Lymantria dispar) larvae infected with multiple nucleopolyhedrovirus (LdMNPV), and LdMNPV-free larvae, were treated with oligoDNA antisense to the RING (really interesting new gene) domain of the LdMNPV IAP-3 gene. The results with respect to insect mortality, biomass accumulation, histological studies, RT-PCR, and analysis of DNA apoptotic fragmentation suggest that oligoRING induced increased apoptotic processes in both LdMNPV-free and LdMNPV-infected insect cells, but were more pronounced in the latter. These data open up possibilities for promising new routes of insect pest control using antisense phosphodiester DNA oligonucleotides

Collimation of a Circulating Beam in the U_70 Synchrotron by Use of Reflections in Axially - Oriented Crystals

The possibilities of the extraction and collimation of a circulating beam by a new method due to the reflection of particles in crystals with axial orientation were experimentally investigated in the Fall-2010 run at the U_70 synchrotron. Such crystals have positive features, because the axial potential is five times larger than the planar potential. It has been shown that the collimation efficiency can reach 90% due to axial effects in the crystal. Losses of the circulating beam on a collimator have been reduced by several times; this makes it possible to suppress the muon jet near the steel collimator of the circulating beam.Comment: 6 pages, 7 figure

ДЕТАЛИЗАЦИЯ НАДВИГОВЫХ СТРУКТУР ОСАДОЧНОГО ЧЕХЛА В КОВЫКТИНСКО-ХАНДИНСКОЙ ЗОНЕ ОТРАЖЕННОЙ СКЛАДЧАТОСТИ

The Kovykta-Khandinskaya zone, which includes the Kovykta gas condensate field, is a giant located in the junction zone of the Angara-Lena stage with the craton edge – the Cis-Baikal trough. Here, according to the results of long-term geological exploration, the Verkhnelenskoe uplift was identified, the northern part of which is reflected on tectonic maps as the Kovykta ledge. At the same time, the geological model of the field today is based on the standard two-member model, which includes a slightly disturbed sedimentary cover and basement. However, new geophysical studies revealed that the sedimentary cover of the eastern part of the zone is intensely deformed and has a two-tiered nodular-thrust structure (the lower layer is autochthon, the upper layer is allochthon). The main object for gas exploration within the Kovykta gas condensate field is the Vendian formation. The middle (halogen-carbonate) section has been studied fragmentarily, mainly as an object of geological geohazards when drilling deep wells. The involvement of new data from 3D seismic and 3D transient electromagnetic methods made it possible to clarify the Kovykta gas condensate field tectonic structure to assess the potential of secondary carbonate reservoirs characterized by intense fluid (natural gas, brines) inflows.Ковыктинско-Хандинская зона, включающая Ковыктинское газоконденсатное месторождениегигант,расположена в области сочленения Ангаро-Ленской ступени с краевой областью платформы – Прибайкальским прогибом. Здесь по результатам многолетних геологоразведочных работ выявлено Верхнеленское поднятие, северная часть которого отражена на тектонических картах как Ковыктинский выступ. При этом геологическое строение месторождения на сегодняшний день основывается на стандартной модели: слабонарушенный платформенный чехол – фундамент. Однако новыми геофизическими исследованиями выявлено, что осадочный чехол восточной части зоны интенсивно деформирован и имеет двухъярусное надвиговое строение (нижний ярус – автохтон, верхний – аллохтон). Основным объектом газопоисковых работ в пределах Ковыктинского месторождения являются вендские отложения. Средняя (галогенно-карбонатная) часть разреза изучена фрагментарно, в основном как объект геологических осложнений при проходке глубоких скважин. Привлечение новых данных площадных сейсмо- и электроразведочных исследований позволило уточнить структурно-тектоническое строение Ковыктинского газоконденсатного месторождения, оценить потенциал вторичных карбонатных коллекторов в аллохтоне, проявляющихся интенсивными притоками пластовых флюидов (природный газ, высокоминерализованные рассолы)

A unified framework for multi-locus association analysis of both common and rare variants

<p>Abstract</p> <p>Background</p> <p>Common, complex diseases are hypothesized to result from a combination of common and rare genetic variants. We developed a unified framework for the joint association testing of both types of variants. Within the framework, we developed a union-intersection test suitable for genome-wide analysis of single nucleotide polymorphisms (SNPs), candidate gene data, as well as medical sequencing data. The union-intersection test is a composite test of association of genotype frequencies and differential correlation among markers.</p> <p>Results</p> <p>We demonstrated by computer simulation that the false positive error rate was controlled at the expected level. We also demonstrated scenarios in which the multi-locus test was more powerful than traditional single marker analysis. To illustrate use of the union-intersection test with real data, we analyzed a publically available data set of 319,813 autosomal SNPs genotyped for 938 cases of Parkinson disease and 863 neurologically normal controls for which no genome-wide significant results were found by traditional single marker analysis. We also analyzed an independent follow-up sample of 183 cases and 248 controls for replication.</p> <p>Conclusions</p> <p>We identified a single risk haplotype with a directionally consistent effect in both samples in the gene <it>GAK</it>, which is involved in clathrin-mediated membrane trafficking. We also found suggestive evidence that directionally inconsistent marginal effects from single marker analysis appeared to result from risk being driven by different haplotypes in the two samples for the genes <it>SYN3 </it>and <it>NGLY1</it>, which are involved in neurotransmitter release and proteasomal degradation, respectively. These results illustrate the utility of our unified framework for genome-wide association analysis of common, complex diseases.</p

Simultaneous Analysis of All SNPs in Genome-Wide and Re-Sequencing Association Studies

Testing one SNP at a time does not fully realise the potential of genome-wide association studies to identify multiple causal variants, which is a plausible scenario for many complex diseases. We show that simultaneous analysis of the entire set of SNPs from a genome-wide study to identify the subset that best predicts disease outcome is now feasible, thanks to developments in stochastic search methods. We used a Bayesian-inspired penalised maximum likelihood approach in which every SNP can be considered for additive, dominant, and recessive contributions to disease risk. Posterior mode estimates were obtained for regression coefficients that were each assigned a prior with a sharp mode at zero. A non-zero coefficient estimate was interpreted as corresponding to a significant SNP. We investigated two prior distributions and show that the normal-exponential-gamma prior leads to improved SNP selection in comparison with single-SNP tests. We also derived an explicit approximation for type-I error that avoids the need to use permutation procedures. As well as genome-wide analyses, our method is well-suited to fine mapping with very dense SNP sets obtained from re-sequencing and/or imputation. It can accommodate quantitative as well as case-control phenotypes, covariate adjustment, and can be extended to search for interactions. Here, we demonstrate the power and empirical type-I error of our approach using simulated case-control data sets of up to 500 K SNPs, a real genome-wide data set of 300 K SNPs, and a sequence-based dataset, each of which can be analysed in a few hours on a desktop workstation