Design and analysis considerations for deployment mechanisms in a space environment

On the second flight of the INTELSAT V spacecraft the time required for successful deployment of the north solar array was longer than originally predicted. The south solar array deployed as predicted. As a result of the difference in deployment times a series of experiments was conducted to locate the cause of the difference. Deployment rate sensitivity to hinge friction and temperature levels was investigated. A digital computer simulation of the deployment was created to evaluate the effects of parameter changes on deployment. Hinge design was optimized for nominal solar array deployment time for future INTELSAT V satellites. The nominal deployment times of both solar arrays on the third flight of INTELSAT V confirms the validity of the simulation and design optimization

SCREENING FOR HEPATITIS C Response from Hepatitis C Trust, BASL, BIA, BVHG, BSG, and BHIVA to article asking whether widespread screening for hepatitis C is justified

This is the peer reviewed published version of the following article: Response from Hepatitis C Trust, BASL, BIA, BVHG, BSG, and BHIVA to article asking whether widespread screening for hepatitis C is justified, which has been published in final form at 10.1136/bmj.h998. This article may be used for non-commercial purposes in accordance with BMJ's Terms and Conditions for Self-Archiving.This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/ by/4.0

Clonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus.

We quantitated and characterized the changes in the human B cell repertoire, at the clonal level, before and after immunization with rabies virus. Moreover, we generated 10 monoclonal cell lines producing IgM, IgG, and IgA antibodies to the virus. We found that in healthy subjects, not previously exposed to the virus, nearly 2% of the circulating B lymphocytes were committed to the production of antibodies that bound the virus. These B cells expressed the surface CD5 molecule. The antibodies they produced were polyreactive IgM that displayed a relatively low affinity for the virus components (Kd, 1.0-2.4 x 10(-6) g/microliters). After immunization, different anti-virus (IgG and IgA) antibody-producing cells consistently appeared in the circulation and increased from less than 0.005% to greater than 10% of the total B cells committed to the production of IgG and IgA, respectively. Most of such B cells do not express CD5 and produce monoreactive antibodies of high affinity for rabies virus (Kd, 6.5 x 10(-9) to 1.2 x 10(-10) g/microliters). One of these IgG mAbs efficiently neutralized rabies virus in vitro and in vivo, as detailed elsewhere (Dietzschold, B., P. Casali, Y. Ueki, M. Gore, C. E. Rupprecht, A. L. Notkins, and H. Koprowski, manuscript submitted for publication). Hybridization experiments using probes specific for the different human V gene segment families revealed that cell precursors producing low affinity IgM binding to rabies virus utilized a restricted number of VH gene segments (i.e., only members of the VHIIIb subfamily), whereas cell precursors producing high affinity IgG and IgA to rabies virus utilized an assortment of different VH gene segments (i.e., members of the VHI, VHIII, VHIV, and VHVI families and VHIIIb subfamily). In conclusion, our studies show that EBV transformation in conjunction with limiting dilution technology and somatic cell hybridization techniques are useful methods for quantitating, at the B cell clonal level, the human antibody response to foreign Ags and for generating human mAbs of predetermined specificity and high affinity

Chemical kinetic considerations for postflame synthesis of carbon nanotubes in premixed flames using a support catalyst

Multiwalled carbon nanotubes (MWCNTs) on a grid supported cobalt nanocatalyst were grown, by exposing it to combustion gases from ethylene/air rich premixed flames. Ten equivalence ratios (φ) were investigated, as follows: 1.37, 1.44, 1.47, 1.50, 1.55, 1.57, 1.62, 1.75, 1.82, and 1.91. MWCNT growth could be observed for the range of equivalence ratios between 1.45 and 1.75, with the best yield restricted to the range 1.5–1.6. A one-dimensional premixed flame code with a postflame heat loss model, including detailed chemistry, was used to estimate the gas phase chemical composition that favorsMWCNT growth. The results of the calculations show that the mixture, including the water gas shift reaction, is not even in partial chemical equilibrium. Therefore, past discussions of compositional parameters that relate to optimum carbon nanotube (CNT) growth are revised to include chemical kinetic effects. Specifically, rapid departures of the water gas shift reaction from partial equilibrium and changes in mole fraction ratios of unburned C2 hydrocarbons to hydrogen correlate well with experimentally observed CNT yields

Interprofessional Education Through Home Modification

Creating safe and accessible environments for all people, including physical, sensory, and cognitive disabilities is an important part of training students in occupational therapy, physical therapy, and interior design. Approximately 125 students from these disciplines worked together during a unique interprofessional experience, to perform everyday tasks with a simulated disability, then collaborated as interprofessional teams to make recommendations for home environment modifications to improve safety and accessibility for individuals with physical challenges. This was a unique opportunity for all the students to learn about other disciplines and the expertise that each brings to the table to help our clients

Radiation Intensity of a Turbulent Sooting Ethylene Flame

Turbulent sooting flame radiation is relevant to applications ranging from fire safety to gas turbine engines. The complex direct interactions of soot and radiation intensity are of particular importance when creating accurate soot prediction models. Previous studies have measured gas-band and broadband radiation intensity from turbulent sooting flames. The focus of the current study is the characterization of radiation intensity emanating from soot. A high-speed infrared camera (FLIR Phoenix) was used to acquire time-dependent quantitative images of radiation intensity of a turbulent sooting ethylene flame. The flame had a Reynolds number of 15,200 and was stabilized on a burner with an exit diameter of 8mm. The radiation intensity was collected utilizing a bandpass filter (3.77 ± .12 μm) to limit the radiation intensity source to soot. Time-dependent and time-averaged soot radiation intensities are plotted. Radiation intensity structures similar to those found in soot volume fraction diagnostics are observed and statistical analyses are employed to characterize the distribution of soot radiation intensity. The centerline distribution of radiation intensity from soot was qualitatively similar to earlier measurements of gas-band radiation intensity. Time-dependent images of radiation intensity exhibited discrete structures similar to images of soot volume fraction measured by laser-induced incandescence

Radiation Measurements and Data Analysis of Turbulent Premixed Lean Flame

An accurate understanding of the radiation transfer in turbulent premixed lean flame is critical for improving energy efficiencies and reducing emissions such as nitric oxide and soot. Radiation measurement is an effective and nonintrusive way to study the radiation properties of turbulent premixed lean flames. In this study, a high-speed infrared camera was utilized to measure the planar radiation from turbulent premixed lean flames under different conditions. Time-dependent flame images were acquired and radiation statistics were calculated and compared to investigate the effects of equivalence ratio, heat release rate, hydrogen pilot flame rate, and co-flow rate on the radiation intensity of the flames. Results show that radiation intensity increases with equivalence ratio and heat release rate. However, changes of hydrogen pilot flame rate and co-flow rate have little impact on the radiation intensity. These experimental data are essential for the study of turbulent premixed lean flames and the calibration of the empirical relations in the simulation models