Landscape preservation under post‐European settlement alluvium in the south‐eastern Australian tablelands, inferred from portable OSL reader data

Human land‐use changes leading to widespread erosion and gully incision have been well studied, but the effects that erosion and sediment mixing, which accompany the deposition of post‐(European) settlement alluvium (PSA), have in valley bottoms and wetlands receive considerably less attention. PSA overlying pre‐disturbance swampy meadow (SM) wetland sediments is commonly exposed along incised stream channel gully walls throughout the south‐eastern Australian Tablelands, providing an ideal setting in which to assess and understand better how PSA deposition affects valley bottoms and the wetland environments that often occupy them. Portable optically stimulated luminescence (pOSL) reader data were measured on bulk sediment samples from SM‐PSA stratigraphies at 16 locations throughout the south‐eastern Australian Tablelands to assess the effects of erosion and sediment mixing at the SM‐PSA boundary. Trends of pOSL data with depth at each profile were used in conjunction with visual profile descriptions to identify the stratigraphic boundary between SM and PSA sediment and to infer the degree of valley bottom erosion and sediment mixing during PSA deposition. At most sites, SM sediments experienced minimal, if any, disturbance during PSA deposition, and we refer to these as non‐eroded sites. Many sites, however, experienced a significant degree of erosion and sediment mixing – eroded sites – often corresponding to visually diffuse sedimentary boundaries between the two stratigraphic units. Our findings demonstrate that SM landscapes in the Tablelands can be preserved with minimal disturbance under PSA at non‐eroded sites and are preserved beneath a mixing zone at all eroded sites. Copyright © 2016 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134129/1/esp3942.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134129/2/esp3942_am.pd

A community-based geological reconstruction of Antarctic Ice Sheet deglaciation since the Last Glacial Maximum

A robust understanding of Antarctic Ice Sheet deglacial history since the Last Glacial Maximum is important in order to constrain ice sheet and glacial-isostatic adjustment models, and to explore the forcing mechanisms responsible for ice sheet retreat. Such understanding can be derived from a broad range of geological and glaciological datasets and recent decades have seen an upsurge in such data gathering around the continent and Sub-Antarctic islands. Here, we report a new synthesis of those datasets, based on an accompanying series of reviews of the geological data, organised by sector. We present a series of timeslice maps for 20ka, 15ka, 10ka and 5ka, including grounding line position and ice sheet thickness changes, along with a clear assessment of levels of confidence. The reconstruction shows that the Antarctic Ice sheet did not everywhere reach the continental shelf edge at its maximum, that initial retreat was asynchronous, and that the spatial pattern of deglaciation was highly variable, particularly on the inner shelf. The deglacial reconstruction is consistent with a moderate overall excess ice volume and with a relatively small Antarctic contribution to meltwater pulse 1a. We discuss key areas of uncertainty both around the continent and by time interval, and we highlight potential priorit. © 2014 The Authors

The Human Phenotype Ontology in 2024: phenotypes around the world.

The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English. Since our last report, a total of 2239 new HPO terms and 49235 new HPO annotations were developed, many in collaboration with external groups in the fields of psychiatry, arthrogryposis, immunology and cardiology. The Medical Action Ontology (MAxO) is a new effort to model treatments and other measures taken for clinical management. Finally, the HPO consortium is contributing to efforts to integrate the HPO and the GA4GH Phenopacket Schema into electronic health records (EHRs) with the goal of more standardized and computable integration of rare disease data in EHRs

Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial

Background: The EMPA KIDNEY trial showed that empagliflozin reduced the risk of the primary composite outcome of kidney disease progression or cardiovascular death in patients with chronic kidney disease mainly through slowing progression. We aimed to assess how effects of empagliflozin might differ by primary kidney disease across its broad population. Methods: EMPA-KIDNEY, a randomised, controlled, phase 3 trial, was conducted at 241 centres in eight countries (Canada, China, Germany, Italy, Japan, Malaysia, the UK, and the USA). Patients were eligible if their estimated glomerular filtration rate (eGFR) was 20 to less than 45 mL/min per 1·73 m2, or 45 to less than 90 mL/min per 1·73 m2 with a urinary albumin-to-creatinine ratio (uACR) of 200 mg/g or higher at screening. They were randomly assigned (1:1) to 10 mg oral empagliflozin once daily or matching placebo. Effects on kidney disease progression (defined as a sustained ≥40% eGFR decline from randomisation, end-stage kidney disease, a sustained eGFR below 10 mL/min per 1·73 m2, or death from kidney failure) were assessed using prespecified Cox models, and eGFR slope analyses used shared parameter models. Subgroup comparisons were performed by including relevant interaction terms in models. EMPA-KIDNEY is registered with ClinicalTrials.gov, NCT03594110. Findings: Between May 15, 2019, and April 16, 2021, 6609 participants were randomly assigned and followed up for a median of 2·0 years (IQR 1·5–2·4). Prespecified subgroupings by primary kidney disease included 2057 (31·1%) participants with diabetic kidney disease, 1669 (25·3%) with glomerular disease, 1445 (21·9%) with hypertensive or renovascular disease, and 1438 (21·8%) with other or unknown causes. Kidney disease progression occurred in 384 (11·6%) of 3304 patients in the empagliflozin group and 504 (15·2%) of 3305 patients in the placebo group (hazard ratio 0·71 [95% CI 0·62–0·81]), with no evidence that the relative effect size varied significantly by primary kidney disease (pheterogeneity=0·62). The between-group difference in chronic eGFR slopes (ie, from 2 months to final follow-up) was 1·37 mL/min per 1·73 m2 per year (95% CI 1·16–1·59), representing a 50% (42–58) reduction in the rate of chronic eGFR decline. This relative effect of empagliflozin on chronic eGFR slope was similar in analyses by different primary kidney diseases, including in explorations by type of glomerular disease and diabetes (p values for heterogeneity all >0·1). Interpretation: In a broad range of patients with chronic kidney disease at risk of progression, including a wide range of non-diabetic causes of chronic kidney disease, empagliflozin reduced risk of kidney disease progression. Relative effect sizes were broadly similar irrespective of the cause of primary kidney disease, suggesting that SGLT2 inhibitors should be part of a standard of care to minimise risk of kidney failure in chronic kidney disease. Funding: Boehringer Ingelheim, Eli Lilly, and UK Medical Research Council

Application of reactive barriers operated in frozen ground

Permeable reactive barriers allow passive treatment of contaminated groundwater. Barriers, filled with reactive media, are able to treat a wide range of contaminants including dissolved nutrients and metals, petroleum hydrocarbons and chlorinated organic compounds. Advantages for areas of frozen ground include low energy requirements, the ability to function unattended, and a low cost of operation. Although freeze-thaw cycling poses additional challenges to their successful operation, barriers are now helping to remediate contaminated sites in Antarctica and the Arctic.18 page(s

Geochemical insights to the formation of "sedimentary buffers" : considering the role of tributary-trunk stream interactions on catchment-scale sediment flux and drainage network dynamics

The concept of disconnectivity (or decoupling) of sediment movement in river systems is an important concept in analyses of sediment flux in catchments. At the catchment scale, various blockages-termed buffers, barriers and blankets-form along the sediment cascade, interrupting the conveyance of sediments downstream. Long-lived buffers can control aspects of catchment sediment flux for an extended period.The upper Hunter catchment has a highly disconnected sediment cascade. The most highly disconnected subcatchment (Dart Brook) contains a distinct type of buffer, a trapped tributary fill, in its downstream reaches, reducing the effective catchment area of the upper Hunter catchment by ∼ 18%. We test the use of elemental analyses provided by X-ray fluorescence (XRF) spectrometry of homogenous sediment profiles taken from floodplain bank exposures to determine that the geochemical composition of the sediments that make up this trapped-tributary fill system have been derived from two distinct source areas (the tributary system and the trunk stream). Over at least the Holocene, sedimentation along the axis of the Hunter River valley (the trunk stream) has formed an impediment to sediment conveyance along the lower tributary catchment, essentially "trapping" the tributary. We present an evolutionary model of how this type of "blockage" has formed and discuss implications of tributary-trunk stream (dis)connectivity in analysis of catchment-scale sediment flux and drainage network dynamics. In this case, a relatively large tributary network is having a "geomorphically insignificant" impact on trunk stream dynamics.9 page(s

Immobilization and encapsulation of contaminants using silica treatments : a review

The immobilization and encapsulation of contaminants using silica treatments is an emerging technology for the management of contaminated land. This article reviews the potential of silica treatments for the management of metals, hydrocarbons, and acid mine drainage at contaminated sites; and evaluates the effects of environmental conditions on silica treatment performance. The review demonstrates the potential of silica treatments for managing contaminated land; however, a paucity of research offers only a limited understanding of this technology. Further development of the technology will require additional research evaluating its long-term performance under a range of environmental conditions. Field-based experiments and studies investigating potential adverse effects of silica treatments are also necessary to demonstrate the safety, efficacy, and reliability of silica treatments.19 page(s

Asyut 422, seltman GROUP P, and the imitation of attic coins

The ‘Attic’ tetradrachm, Asyut 422, was identified by Price and Waggoner as a contemporary imitation. Seltman placed a die-linked example in his group p. His arguments for the attribution of this group to a mint set up by an Athenian colony at Chalcis on Euboea are challenged. Compositional analyses using x-ray fluorescence spectrometry are presented, which indicate that Asyut 422 was not made of silver from Laurion.18 page(s

Suitability of transportable EDXRF for the on-site assessment of ancient silver coins and other silver artifacts

Transportable energy dispersive X-ray fluorescence (XRF) spectrometers allow the elemental composition of coins to be measured at collections, enhancing security while maximizing access to historically important material. We assessed 10 silver coins, using five XRF spectrometers. We found no systematic differences between analyses using Mo- and Rh-anode tubes, and no substantial advantage using He flush over air for elements heavier than Ti. Higher voltage X-ray tubes enhanced analytical precision. Understanding patina composition made a numerical correction possible, allowing an approximation of the underlying coin metal with good results for metals including Cu, Ag, Au, Pb, and Bi