Performing the Other: Indigenous Identity and Regional Resistance in Sonoran Literature of the 1980\u27s

During the decade of the 1980’s there occurs a preoccupation, presence and notable change in the representation of the indígena in the cultural production of the State of Sonora. This articulation of a modified ethnic discourse is a product of the economic and social changes that impacted the region during this period. Through a detailed examination of three Sonoran writers we observe how this ethnic discourse leads to a reformulation the traditional images of the indígena and reflects the negotiation between local and national interests to determine the meaning of the region, its identity and its place within the nation

Linear combinations of docking affinities explain quantitative differences in RTK signaling

Receptor tyrosine kinases (RTKs) process extracellular cues by activating a broad array of signaling proteins. Paradoxically, they often use the same proteins to elicit diverse and even opposing phenotypic responses. Binary, ‘on–off' wiring diagrams are therefore inadequate to explain their differences. Here, we show that when six diverse RTKs are placed in the same cellular background, they activate many of the same proteins, but to different quantitative degrees. Additionally, we find that the relative phosphorylation levels of upstream signaling proteins can be accurately predicted using linear models that rely on combinations of receptor-docking affinities and that the docking sites for phosphoinositide 3-kinase (PI3K) and Shc1 provide much of the predictive information. In contrast, we find that the phosphorylation levels of downstream proteins cannot be predicted using linear models. Taken together, these results show that information processing by RTKs can be segmented into discrete upstream and downstream steps, suggesting that the challenging task of constructing mathematical models of RTK signaling can be parsed into separate and more manageable layers

El Diálogo Cultural y la Transformación Genérica en El Mariachi de Robert Rodríguez

(First paragraph) El Mariachi (1993) de Robert Rodriguez ha recibido un gran número de elogios de la crítica y reconocimiento de la industria cinemática por su creatividad y su historia productiva única. Le película ganó el premio de Audience Award en el festival de cine de Sundance y posteriormente fue estrenada en video por Colombia Pictures. Desde entonces Robert Rodriguez ha llegado a ser uno de los directores latinos más destacado

Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

Advances in the generation and interpretation of proteomics data have spurred a transition from focusing on protein identification to functional analysis. Here we review recent proteomics results that have elucidated new aspects of the roles and regulation of signal transduction pathways in cancer using the epidermal growth factor receptor (EGFR), ERK and breakpoint cluster region (BCR)-ABL1 networks as examples. The emerging theme is to understand cancer signalling as networks of multiprotein machines which process information in a highly dynamic environment that is shaped by changing protein interactions and post-translational modifications (PTMs). Cancerous genetic mutations derange these protein networks in complex ways that are tractable by proteomics