Phonographic neighbors, not orthographic neighbors, determine word naming latencies

The orthographic neighborhood size (N) of a word—the number of words that can be formed from that word by replacing one letter with another in its place—has been found to have facilitatory effects in word naming. The orthographic neighborhood hypothesis attributes this facilitation to interactive effects. A phonographic neighborhood hypothesis, in contrast, attributes the effect to lexical print-sound conversion. According to the phonographic neighborhood hypothesis, phonographic neighbors (words differing in one letter and one phoneme, e.g., stove and stone) should facilitate naming, and other orthographic neighbors (e.g., stove and shove) should not. The predictions of these two hypotheses are tested. Unique facilitatory phonographic N effects were found in four sets of word naming mega-study data, along with an absence of facilitatory orthographic N effects. These results implicate print-sound conversion—based on consistent phonology—in neighborhood effects rather than word-letter feedback

A protocol for a randomised controlled trial of prefabricated versus customised foot orthoses for people with rheumatoid arthritis: the FOCOS RA trial [Foot Orthoses – Customised v Off-the-Shelf in Rheumatoid Arthritis]

Abstract Background Foot pain is common in rheumatoid arthritis and appears to persist despite modern day medical management. Several clinical practice guidelines currently recommend the use of foot orthoses for the treatment of foot pain in people with rheumatoid arthritis. However, an evidence gap currently exists concerning the comparative clinical- and cost-effectiveness of prefabricated and customised foot orthoses in people with early rheumatoid arthritis. Early intervention with orthotics may offer the best opportunity for positive therapeutic outcomes. The primary aim of this study is to evaluate the comparative clinical- and cost-effectiveness of prefabricated versus customised orthoses for reducing foot pain over 12 months. Methods/design This is a multi-centre two-arm parallel randomised controlled trial comparing prefabricated versus customised orthoses in participants with early rheumatoid arthritis (< 2 years disease duration). A total of 160 (a minimum of 80 randomised to each arm) eligible participants will be recruited from United Kingdom National Health Service Rheumatology Outpatient Clinics. The primary outcome will be foot pain measured via the Foot Function Index pain subscale at 12 months. Secondary outcomes will include foot related impairments and disability via the Foot Impact Scale for rheumatoid arthritis, global functional status via the Stanford Health Assessment Questionnaire, foot disease activity via the Rheumatoid Arthritis Foot Disease Activity Index, and health-related quality of life at baseline, 6 and 12 months. Process outcomes will include recruitment/retention rates, data completion rates, intervention adherence rates, and participant intervention and trial participation satisfaction. Cost-utility and cost-effectiveness analyses will be undertaken. Discussion Outcome measures collected at baseline, 6 and 12 months will be used to evaluate the comparative clinical- and cost- effectiveness of customised versus prefabricated orthoses for this treatment of early rheumatoid arthritis foot conditions. This trial will help to guide orthotic prescription recommendations for the management of foot pain for people with early rheumatoid arthritis in future. Trial registration ISRCTN13654421. Registered 09 February 2016

Modeling lexical decision : the form of frequency and diversity effects

What is the root cause of word frequency effects on lexical decision times? W. S. Murray and K. I. Forster (2004) argued that such effects are linear in rank frequency, consistent with a serial search model of lexical access. In this article, the authors (a) describe a method of testing models of such effects that takes into account the possibility of parametric overfitting; (b) illustrate the effect of corpus choice on estimates of rank frequency; (c) give derivations of nine functional forms as predictions of models of lexical decision; (d) detail the assessment of these models and the rank model against existing data regarding the functional form of frequency effects; and (e) report further assessments using contextual diversity, a factor confounded with word frequency. The relationship between the occurrence distribution of words and lexical decision latencies to those words does not appear compatible with the rank hypothesis, undermining the case for serial search models of lexical access. Three transformations of contextual diversity based on extensions of instance models do, however, remain as plausible explanations of the effect

Methods of testing and diagnosing model error : dual and single route cascaded models of reading aloud

Models of visual word recognition have been assessed by both factorial and regression approaches. Factorial approaches tend to provide a relatively weak test of models, and regression approaches give little indication of the sources of models’ mispredictions, especially when parameters are not optimal. A new alternative method, involving regression on model error, combines these two approaches with parameter optimization. The method is illustrated with respect to the dual route cascaded model of reading aloud. In contrast to previous investigations, this method provides clear evidence that there are parameter-independent problems with the model, and identifies two specific sources of misprediction made by model