Evolution of clonal populations approaching a fitness peak

Populations facing novel environments are expected to evolve through the accumulation of adaptive substitutions. The dynamics of adaptation depend on the fitness landscape and possibly on the genetic background on which new mutations arise. Here, we model the dynamics of adaptive evolution at the phenotypic and genotypic levels, focusing on a Fisherian landscape characterized by a single peak. We find that Fisher's geometrical model of adaptation, extended to allow for small random environmental variations, is able to explain several features made recently in experimentally evolved populations. Consistent with data on populations evolving under controlled conditions, the model predicts that mean population fitness increases rapidly when populations face novel environments and then achieves a dynamic plateau, the rate of molecular evolution is remarkably constant over long periods of evolution, mutators are expected to invade and patterns of epistasis vary along the adaptive walk. Negative epistasis is expected in the initial steps of adaptation but not at later steps, a prediction that remains to be tested. Furthermore, populations are expected to exhibit high levels of phenotypic diversity at all times during their evolution. This implies that populations are possibly able to adapt rapidly to novel abiotic environments.CAPES-IGC

Conditional Image-Text Embedding Networks

This paper presents an approach for grounding phrases in images which jointly learns multiple text-conditioned embeddings in a single end-to-end model. In order to differentiate text phrases into semantically distinct subspaces, we propose a concept weight branch that automatically assigns phrases to embeddings, whereas prior works predefine such assignments. Our proposed solution simplifies the representation requirements for individual embeddings and allows the underrepresented concepts to take advantage of the shared representations before feeding them into concept-specific layers. Comprehensive experiments verify the effectiveness of our approach across three phrase grounding datasets, Flickr30K Entities, ReferIt Game, and Visual Genome, where we obtain a (resp.) 4%, 3%, and 4% improvement in grounding performance over a strong region-phrase embedding baseline.Comment: ECCV 2018 accepted pape

Clonal interference and Muller's ratchet in spatial habitats

Competition between independently arising beneficial mutations is enhanced in spatial populations due to the linear rather than exponential growth of clones. Recent theoretical studies have pointed out that the resulting fitness dynamics is analogous to a surface growth process, where new layers nucleate and spread stochastically, leading to the build up of scale-invariant roughness. This scenario differs qualitatively from the standard view of adaptation in that the speed of adaptation becomes independent of population size while the fitness variance does not. Here we exploit recent progress in the understanding of surface growth processes to obtain precise predictions for the universal, non-Gaussian shape of the fitness distribution for one-dimensional habitats, which are verified by simulations. When the mutations are deleterious rather than beneficial the problem becomes a spatial version of Muller's ratchet. In contrast to the case of well-mixed populations, the rate of fitness decline remains finite even in the limit of an infinite habitat, provided the ratio $U_d/s^2$ between the deleterious mutation rate and the square of the (negative) selection coefficient is sufficiently large. Using again an analogy to surface growth models we show that the transition between the stationary and the moving state of the ratchet is governed by directed percolation

An ABC Method for Estimating the Rate and Distribution of Effects of Beneficial Mutations

Determining the distribution of adaptive mutations available to natural selection is a difficult task. These are rare events and most of them are lost by chance. Some theoretical works propose that the distribution of newly arising beneficial mutations should be close to exponential. Empirical data are scarce and do not always support an exponential distribution. Analysis of the dynamics of adaptation in asexual populations of microorganisms has revealed that these can be summarized by two effective parameters, the effective mutation rate, Ue, and the effective selection coefficient of a beneficial mutation, Se. Here, we show that these effective parameters will not always reflect the rate and mean effect of beneficial mutations, especially when the distribution of arising mutations has high variance, and the mutation rate is high. We propose a method to estimate the distribution of arising beneficial mutations, which is motivated by a common experimental setup. The method, which we call One Biallelic Marker Approximate Bayesian Computation, makes use of experimental data consisting of periodic measures of neutral marker frequencies and mean population fitness. Using simulations, we find that this method allows the discrimination of the shape of the distribution of arising mutations and that it provides reasonable estimates of their rates and mean effects in ranges of the parameter space that may be of biological relevance.Fundação Calouste Gulbenkian, FCT, LAO/ITQB, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE), program PRONEX/MCT-CNPq-FACEPE

Satellite Star Tracker Breadboard with Space Debris Detection Capability for LEO

This paper evaluates the possibility of having a star tracker device running space debris algorithms. A simple star tracker breadboard was developed to evaluate the possibility of having a device running both stellar identification and space debris algorithms. The breadboard was built with commercial off-the-shelf components, representing the current star tracker resolution and field of view. A star tracker device and space debris algorithms were implemented and tested, respectively: Tetra and ASTRiDE. The device concept was tested by taking pictures of the night sky with satellite streaks. Seeking to overcome such limitations, a dual-purpose star tracker with stars detection and optical debris detection capability is proposed. Star trackers are usually used in satellites for attitude determination and therefore have a vast potential to be a major tool for space debris detection. The rapid increase of space debris poses a risk to space activities, so it is vital to detect it. Ground-based radar and optical telescope techniques used for debris detection are limited by a size threshold, detecting only a tiny amount of the total, reason why evaluating the possibility of detecting them in space is of major importance.info:eu-repo/semantics/publishedVersio

3DFeat-Net: Weakly Supervised Local 3D Features for Point Cloud Registration

In this paper, we propose the 3DFeat-Net which learns both 3D feature detector and descriptor for point cloud matching using weak supervision. Unlike many existing works, we do not require manual annotation of matching point clusters. Instead, we leverage on alignment and attention mechanisms to learn feature correspondences from GPS/INS tagged 3D point clouds without explicitly specifying them. We create training and benchmark outdoor Lidar datasets, and experiments show that 3DFeat-Net obtains state-of-the-art performance on these gravity-aligned datasets.Comment: 17 pages, 6 figures. Accepted in ECCV 201

Evolución a la detección precoz de gravedad. ¿Hacia dónde vamos?.

En publicaciones recientes (1,2), se ha puesto de manifiesto como es necesario incrementar la monitorización de los pacientes ingresados en plantas convencionales del hospital, con el objetivo de evitar su posible deterioro clínico, bien aplicando un tratamiento adecuado de forma precoz, o bien mediante el incremento de su monitorización mediante su traslado a Unidades de Cuidados Intensivos (UCI). Se ha podido establecer cómo los diferentes sistemas o algoritmos de identificación de gravedad, aplicados en estos pacientes, han podido reducir la aparición de eventos adversos, prevenir la aparición de paradas cardiorrespiratorias (PCR) y mejorar su pronóstico.pre-print409 K

Are white storks addicted to junk food? Impacts of landfill use on the movement and behaviour of resident white storks (Ciconia ciconia) from a partially migratory population

Background: The migratory patterns of animals are changing in response to global environmental change with many species forming resident populations in areas where they were once migratory. The white stork (Ciconia ciconia) was wholly migratory in Europe but recently guaranteed, year-round food from landfill sites has facilitated the establishment of resident populations in Iberia. In this study 17 resident white storks were fitted with GPS/GSM data loggers (including accelerometer) and tracked for 9.1 ± 3.7 months to quantify the extent and consistency of landfill attendance by individuals during the non-breeding and breeding seasons and to assess the influence of landfill use on daily distances travelled, percentage of GPS fixes spent foraging and non-landfill foraging ranges. Results: Resident white storks used landfill more during non-breeding (20.1 % ± 2.3 of foraging GPS fixes) than during breeding (14.9 % ± 2.2). Landfill attendance declined with increasing distance between nest and landfill in both seasons. During non-breeding a large percentage of GPS fixes occurred on the nest throughout the day (27 % ± 3.0 of fixes) in the majority of tagged storks. This study provides first confirmation of year-round nest use by resident white storks. The percentage of GPS fixes on the nest was not influenced by the distance between nest and the landfill site. Storks travelled up to 48.2 km to visit landfills during non-breeding and a maximum of 28.1 km during breeding, notably further than previous estimates. Storks nesting close to landfill sites used landfill more and had smaller foraging ranges in non-landfill habitat indicating higher reliance on landfill. The majority of non-landfill foraging occurred around the nest and long distance trips were made specifically to visit landfill. Conclusions: The continuous availability of food resources on landfill has facilitated year-round nest use in white storks and is influencing their home ranges and movement behaviour. White storks rely on landfill sites for foraging especially during the non-breeding season when other food resources are scarcer and this artificial food supplementation probably facilitated the establishment of resident populations. The closure of landfills, as required by EU Landfill Directives, will likely cause dramatic impacts on white stork populations

Cabergoline for suppression of puerperal lactation in a prevention of mother-to-child HIV-transmission programme in rural Malawi.

This study shows that cabergoline (single oral-dose) is an acceptable, safe and effective drug for suppressing puerperal lactation. It could be of operational benefit not only for artificial feeding, but also for weaning in those that breast-feed within preventive mother-to-child HIV transmission programmes in resource-limited settings