18 research outputs found
Blutungsrisiko nach photodynamischer Therapie bei Patienten mit Antikoagulantientherapie
Metastasizing neuroendocrine carcinoma of the larynx with calcitonin and somatostatin secretion and CEA production, resembling medullary thyroid carcinoma
Management of significant reactivation of old disciform scars in wet Age-Related Macular Degeneration
Risk factors for breakthrough vitreous hemorrhage after intravitreal anti-VEGF injection in age-related macular degeneration with submacular hemorrhage
Visual outcomes of vitrectomy for polypoidal choroidal vasculopathy-related breakthrough vitreous haemorrhage
Diabetic retinopathy and VEGF.
Diabetic retinopathy remains the leading vascular-associated cause of blindness throughout the world. Its treatment requires a multidisciplinary interventional approach at both systemic and local levels. Current management includes laser photocoagulation, intravitreal steroids, and anti-vascular endothelial growth factor (VEGF) treatment along with systemic blood sugar control. Anti-VEGF therapies, which are less destructive and safer than laser treatments, are being explored as primary therapy for the management of vision-threatening complications of diabetic retinopathy such as diabetic macular edema (DME). This review provides comprehensive information related to VEGF and describes its role in the pathogenesis of diabetic retinopathy, and in addition, examines the mechanisms of action for different antiangiogenic agents in relation to the management of this disease. Medline (Pubmed) searches were carried out with keywords "VEGF", "diabetic retinopathy", and "diabetes" without any year limitation to review relevant manuscripts used for this article
Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2
Purpose:
To investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity.
Methods:
Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in SpectralâDomain Optical Coherence Tomograph (SDâOCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models.
Results:
A total of 134 eyes of 70 patients were included (85 eyes with followâup, mean 4.7 years, range: 1.4â8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm2 (p = 0.005). The progression rate was nonâlinear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity.
Conclusion:
Ellipsoid zone (EZ) loss in MacTel has a nonâlinear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of bestâcorrected visual acuity by EZ location, which may help routine clinical practice