Global water cycle

This research is the MSFC component of a joint MSFC/Pennsylvania State University Eos Interdisciplinary Investigation on the global water cycle extension across the earth sciences. The primary long-term objective of this investigation is to determine the scope and interactions of the global water cycle with all components of the Earth system and to understand how it stimulates and regulates change on both global and regional scales. Significant accomplishments in the past year are presented and include the following: (1) water vapor variability; (2) multi-phase water analysis; (3) global modeling; and (4) optimal precipitation and stream flow analysis and hydrologic processes

Dynamic walking features and improved walking performance in multiple sclerosis patients treated with fampridine (4-aminopyridine)

Background: Impaired walking capacity is a frequent confinement in Multiple Sclerosis (MS). Patients are affected by limitations in coordination, walking speed and the distance they may cover. Also abnormal dynamic walking patterns have been reported, involving continuous deceleration over time. Fampridine (4-aminopyridine), a potassium channel blocker, may improve walking in MS. The objective of the current study was to comprehensively examine dynamic walking characteristics and improved walking capacity in MS patients treated with fampridine. Methods: A sample of N = 35 MS patients (EDSS median: 4) underwent an electronic walking examination prior to (Time 1), and during treatment with fampridine (Time 2). Patients walked back and forth a distance of 25 ft for a maximum period of 6 min (6-minute 25-foot-walk). Besides the total distance covered, average speed on the 25-foot distance and on turns was determined separately for each test minute, at Time 1 and Time 2. Results: Prior to fampridine administration, 27/35 patients (77 %) were able to complete the entire 6 min of walking, while following the administration, 34/35 patients (97 %) managed to walk for 6 min. In this context, walking distance considerably increased and treatment was associated with faster walking and turning across all six test minutes (range of effect sizes: partial eta squared = .34-.72). Importantly, previously reported deceleration across test minutes was consistently observable at Time 1 and Time 2. Discussion: Fampridine administration is associated with improved walking speed and endurance. Regardless of a treatment effect of fampridine, the previously identified, abnormal dynamic walking feature, i.e. the linear decline in walking speed, may represent a robust feature. Conclusions: The dynamic walking feature might hence be considered as a candidate for a new outcome measure in clinical studies involving interventions other than symptomatic treatment, such as immune-modulating medication. Trial registration: DRKS00009228 (German Clinical Trials Register). Date obtained: 25.08.2015

Theory of Parabolic Arcs in Interstellar Scintillation Spectra

Our theory relates the secondary spectrum, the 2D power spectrum of the radio dynamic spectrum, to the scattered pulsar image in a thin scattering screen geometry. Recently discovered parabolic arcs in secondary spectra are generic features for media that scatter radiation at angles much larger than the rms scattering angle. Each point in the secondary spectrum maps particular values of differential arrival-time delay and fringe rate (or differential Doppler frequency) between pairs of components in the scattered image. Arcs correspond to a parabolic relation between these quantities through their common dependence on the angle of arrival of scattered components. Arcs appear even without consideration of the dispersive nature of the plasma. Arcs are more prominent in media with negligible inner scale and with shallow wavenumber spectra, such as the Kolmogorov spectrum, and when the scattered image is elongated along the velocity direction. The arc phenomenon can be used, therefore, to constrain the inner scale and the anisotropy of scattering irregularities for directions to nearby pulsars. Arcs are truncated by finite source size and thus provide sub micro arc sec resolution for probing emission regions in pulsars and compact active galactic nuclei. Multiple arcs sometimes seen signify two or more discrete scattering screens along the propagation path, and small arclets oriented oppositely to the main arc persisting for long durations indicate the occurrence of long-term multiple images from the scattering screen.Comment: 22 pages, 11 figures, submitted to the Astrophysical Journa

Temporal variability and statistics of the Strehl ratio in adaptive-optics images

We have investigated the temporal variability and statistics of the "instantaneous" Strehl ratio. The observations were carried out with the 3.63-m AEOS telescope equipped with a high-order adaptive optics system. In this paper Strehl ratio is defined as the peak intensity of a single short exposure. We have also studied the behaviour of the phase variance computed on the reconstructed wavefronts. We tested the Marechal approximation and used it to explain the observed negative skewness of the Strehl ratio distribution. The estimate of the phase variance is shown to fit a three-parameter Gamma distribution model. We show that simple scaling of the reconstructed wavefronts has a large impact on the shape of the Strehl ratio distribution.Comment: submitted to PAS

Inflammation in benign prostate tissue and prostate cancer in the finasteride arm of the Prostate Cancer Prevention Trial

BACKGROUND: A previous analysis of the placebo arm of the Prostate Cancer Prevention Trial (PCPT) reported 82% overall prevalence of intraprostatic inflammation and identified a link between inflammation and higher-grade prostate cancer and serum PSA. Here we studied these associations in the PCPT finasteride arm. METHODS: Prostate cancer cases (N=197) detected either on a clinically indicated biopsy or on protocol-directed end-of-study biopsy, and frequency-matched controls (N=248) with no cancer on an end-of-study biopsy were sampled from the finasteride arm. Inflammation in benign prostate tissue was visually assessed using digital images of H&E stained sections. Logistic regression was used for statistical analysis. RESULTS: In the finasteride arm, 91.6% of prostate cancer cases and 92.4% of controls had at least one biopsy core with inflammation in benign areas; p < 0.001 for difference compared to placebo arm. Overall, the odds of prostate cancer did not differ by prevalence (OR=0.90, 95% CI 0.44-1.84) or extent (P-trend=0.68) of inflammation. Inflammation was not associated with higher-grade disease (prevalence: OR=1.07, 95% CI 0.43-2.69). Furthermore, mean PSA concentration did not differ by the prevalence or extent of inflammationin either cases or controls. CONCLUSION: The prevalence of intraprostatic inflammation was higher in the finasteride than placebo arm of the PCPT, with no association with higher-grade prostate cancer. IMPACT: Finasteride may attenuate the association between inflammation and higher-grade prostate cancer. Moreover, the missing link between intraprostatic inflammation and PSA suggests that finasteride may reduce inflammation-associated PSA elevation

Newtonian Hydrodynamics of the Coalescence of Black Holes with Neutron Stars I: Tidally locked binaries with a stiff equation of state

We present a detailed study of the hydrodynamical interactions in a Newtonian black hole-neutron star binary during the last stages of inspiral. We consider close binaries which are tidally locked, use a stiff equation of state (with an adiabatic index Gamma=3) throughout, and explore the effect of different initial mass ratios on the evolution of the system. We calculate the gravitational radiation signal in the quadrupole approximation. Our calculations are carried out using a Smooth Particle Hydrodynamics (SPH) code.Comment: Replaces previous version which had figures separate from the text of the paper. Now 47 pages long with 19 embedded figures (the figures are the same, they were renumbered) Uses aaspp4.st