Inflammation in benign prostate tissue and prostate cancer in the finasteride arm of the Prostate Cancer Prevention Trial

BACKGROUND: A previous analysis of the placebo arm of the Prostate Cancer Prevention Trial (PCPT) reported 82% overall prevalence of intraprostatic inflammation and identified a link between inflammation and higher-grade prostate cancer and serum PSA. Here we studied these associations in the PCPT finasteride arm. METHODS: Prostate cancer cases (N=197) detected either on a clinically indicated biopsy or on protocol-directed end-of-study biopsy, and frequency-matched controls (N=248) with no cancer on an end-of-study biopsy were sampled from the finasteride arm. Inflammation in benign prostate tissue was visually assessed using digital images of H&E stained sections. Logistic regression was used for statistical analysis. RESULTS: In the finasteride arm, 91.6% of prostate cancer cases and 92.4% of controls had at least one biopsy core with inflammation in benign areas; p < 0.001 for difference compared to placebo arm. Overall, the odds of prostate cancer did not differ by prevalence (OR=0.90, 95% CI 0.44-1.84) or extent (P-trend=0.68) of inflammation. Inflammation was not associated with higher-grade disease (prevalence: OR=1.07, 95% CI 0.43-2.69). Furthermore, mean PSA concentration did not differ by the prevalence or extent of inflammationin either cases or controls. CONCLUSION: The prevalence of intraprostatic inflammation was higher in the finasteride than placebo arm of the PCPT, with no association with higher-grade prostate cancer. IMPACT: Finasteride may attenuate the association between inflammation and higher-grade prostate cancer. Moreover, the missing link between intraprostatic inflammation and PSA suggests that finasteride may reduce inflammation-associated PSA elevation

A new foundational crisis in mathematics, is it really happening?

The article reconsiders the position of the foundations of mathematics after the discovery of HoTT. Discussion that this discovery has generated in the community of mathematicians, philosophers and computer scientists might indicate a new crisis in the foundation of mathematics. By examining the mathematical facts behind HoTT and their relation with the existing foundations, we conclude that the present crisis is not one. We reiterate a pluralist vision of the foundations of mathematics. The article contains a short survey of the mathematical and historical background needed to understand the main tenets of the foundational issues.Comment: Final versio

Probing Neutralino Resonance Annihilation via Indirect Detection of Dark Matter

The lightest neutralino of R-parity conserving supersymmetric models serves as a compelling candidate to account for the presence of cold dark matter in the universe. In the minimal supergravity (mSUGRA) model, a relic density can be found in accord with recent WMAP data for large values of the parameter $\tan\beta$, where neutralino annihilation in the early universe occurs via the broad s-channel resonance of the pseudoscalar Higgs boson $A$. We map out rates for indirect detection of neutralinos via 1. detection of neutrinos arising from neutralino annihilation in the core of the earth or sun and 2. detection of gamma rays, antiprotons and positrons arising from neutralino annihilation in the galactic halo. If indeed $A$-resonance annihilation is the main sink for neutralinos in the early universe, then signals may occur in the gamma ray, antiproton and positron channels, while a signal in the neutrino channel would likely be absent. This is in contrast to the hyperbolic branch/focus point (HB/FP) region where {\it all} indirect detection signals are likely to occur, and also in contrast to the stau co-annihilation region, where {\it none} of the indirect signals are likely to occur.Comment: 12 pages including 4 eps figure

Supersymmetric Monojets at the Large Hadron Collider

Supersymmetric monojets may be produced at the Large Hadron Collider by the process qg -> squark neutralino_1 -> q neutralino_1 neutralino_1, leading to a jet recoiling against missing transverse momentum. We discuss the feasibility and utility of the supersymmetric monojet signal. In particular, we examine the possible precision with which one can ascertain the neutralino_1-squark-quark coupling via the rate for monojet events. Such a coupling contains information on the composition of the neutralino_1 and helps bound dark matter direct detection cross-sections and the dark matter relic density of the neutralino_1. It also provides a check of the supersymmetric relation between gauge couplings and gaugino-quark-squark couplings.Comment: 46 pages, 10 figures. The appendix has been rewritten to correct an error that appears in all previous versions of the appendix. This error has no effect on the results in the main body of the pape

Neutralino Dark Matter in Minimal Supergravity: Direct Detection vs. Collider Searches

We calculate expected event rates for direct detection of relic neutralinos as a function of parameter space of the minimal supergravity model. Numerical results are presented for the specific case of a $^{73}$Ge detector. We find significant detection rates ($R> 0.01$ events/kg/day) in regions of parameter space most favored by constraints from $B\to X_s\gamma$ and the cosmological relic density of neutralinos. The detection rates are especially large in regions of large $\tan\beta$, where many conventional signals for supersymmetry at collider experiments are difficult to detect. If the parameter $\tan\beta$ is large, then there is a significant probability that the first direct evidence for supersymmetry could come from direct detection experiments, rather than from collider searches for sparticles.Comment: 25 page REVTEX file including 9 PS figure