Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

It is recognized that some mutated cancer genes contribute to the development of many cancer types, whereas others are cancer type specific. For genes that are mutated in multiple cancer classes, mutations are usually similar in the different affected cancer types. Here, however, we report exquisite tumor type specificity for different histone H3.3 driver alterations. In 73 of 77 cases of chondroblastoma (95%), we found p.Lys36Met alterations predominantly encoded in H3F3B, which is one of two genes for histone H3.3. In contrast, in 92% (49/53) of giant cell tumors of bone, we found histone H3.3 alterations exclusively in H3F3A, leading to p.Gly34Trp or, in one case, p.Gly34Leu alterations. The mutations were restricted to the stromal cell population and were not detected in osteoclasts or their precursors. In the context of previously reported H3F3A mutations encoding p.Lys27Met and p.Gly34Arg or p.Gly34Val alterations in childhood brain tumors, a remarkable picture of tumor type specificity for histone H3.3 driver alterations emerges, indicating that histone H3.3 residues, mutations and genes have distinct functions

Historical thinking for senior secondary students: A collection of teaching and learning activities 2022

Online version of the resource: https://oercollective.caul.edu.au/historical-thinking-for-senior-secondary-students/The teaching and learning activities in this book were designed by pre-service History teachers at Deakin University, Australia. The activities cover a wide range of topics from ancient history through to early twenty-first century history and are designed to develop students' historical thinking.Attribution: Historical thinking for senior secondary students: A collection of teaching and learning activities 2022 by Rebecca Cairns (Deakin University) is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.</p