Density classification on infinite lattices and trees

Consider an infinite graph with nodes initially labeled by independent Bernoulli random variables of parameter p. We address the density classification problem, that is, we want to design a (probabilistic or deterministic) cellular automaton or a finite-range interacting particle system that evolves on this graph and decides whether p is smaller or larger than 1/2. Precisely, the trajectories should converge to the uniform configuration with only 0's if p1/2. We present solutions to that problem on the d-dimensional lattice, for any d>1, and on the regular infinite trees. For Z, we propose some candidates that we back up with numerical simulations

Zaragoza en su segundo sitio : con nuevas notas y un apéndice

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200

Surface Brightness Profiles of Composite Images of Compact Galaxies at z~4-6 in the HUDF

The Hubble Ultra Deep Field (HUDF) contains a significant number of B, V and i'-band dropout objects, many of which were recently confirmed to be young star-forming galaxies at z~4-6. These galaxies are too faint individually to accurately measure their radial surface brightness profiles. Their average light profiles are potentially of great interest, since they may contain clues to the time since the onset of significant galaxy assembly. We separately co-add V, i' and z'-band HUDF images of sets of z~4,5 and 6 objects, pre-selected to have nearly identical compact sizes and the roundest shapes. From these stacked images, we are able to study the averaged radial structure of these objects at much higher signal-to-noise ratio than possible for an individual faint object. Here we explore the reliability and usefulness of a stacking technique of compact objects at z~4-6 in the HUDF. Our results are: (1) image stacking provides reliable and reproducible average surface brightness profiles; (2) the shape of the average surface brightness profiles show that even the faintest z~4-6 objects are resolved; and (3) if late-type galaxies dominate the population of galaxies at z~4-6, as previous HST studies have shown, then limits to dynamical age estimates for these galaxies from their profile shapes are comparable with the SED ages obtained from the broadband colors. We also present accurate measurements of the sky-background in the HUDF and its associated 1-sigma uncertainties.Comment: 10 pages, 9 figures, 2 tables, emulateapj; Accepted for publication in The Astronomical Journa

High-resolution copy-number variation map reflects human olfactory receptor diversity and evolution

Abstract Olfactory receptors (ORs), which are involved in odorant recognition, form the largest mammalian protein superfamily. The genomic content of OR genes is considerably reduced in humans, as reflected by the relatively small repertoire size and the high fraction (,55%) of human pseudogenes. Since several recent low-resolution surveys suggested that OR genomic loci are frequently affected by copy-number variants (CNVs), we hypothesized that CNVs may play an important role in the evolution of the human olfactory repertoire. We used high-resolution oligonucleotide tiling microarrays to detect CNVs across 851 OR gene and pseudogene loci. Examining genomic DNA from 25 individuals with ancestry from three populations, we identified 93 OR gene loci and 151 pseudogene loci affected by CNVs, generating a mosaic of OR dosages across persons. Our data suggest that ,50% of the CNVs involve more than one OR, with the largest CNV spanning 11 loci. In contrast to earlier reports, we observe that CNVs are more frequent among OR pseudogenes than among intact genes, presumably due to both selective constraints and CNV formation biases. Furthermore, our results show an enrichment of CNVs among ORs with a close human paralog or lacking a one-to-one ortholog in chimpanzee. Interestingly, among the latter we observed an enrichment in CNV losses over gains, a finding potentially related to the known diminution of the human OR repertoire. Quantitative PCR experiments performed for 122 sampled ORs agreed well with the microarray results and uncovered 23 additional CNVs. Importantly, these experiments allowed us to uncover nine common deletion alleles that affect 15 OR genes and five pseudogenes. Comparison to the chimpanzee reference genome revealed that all of the deletion alleles are human derived, therefore indicating a profound effect of human-specific deletions on the individual OR gene content. Furthermore, these deletion alleles may be used in future genetic association studies of olfactory inter-individual differences

[Carta en latín de Luis Gonzaga de la Encina y Perla al Papa]

Al fin consta: "Datis Arequipae XIV kalendas junias"Las fechas son las que permaneció el autor como Obispo de Arequip

Optical detection of the Pictor A jet and tidal tail : evidence against an IC/CMB jet

Date of Acceptance: 12/06/2015New images of the FR II radio galaxy Pictor A from the Hubble Space Telescope reveal a previously undiscovered tidal tail, as well as a number of jet knots coinciding with a known X-ray and radio jet. The tidal tail is approximately 5″ wide (3 kpc projected), starting 18″ (12 kpc) from the center of Pictor A, and extends more than 90″ (60 kpc). The knots are part of a jet observed to be about 4′ (160 kpc) long, extending to a bright hotspot. These images are the first optical detections of this jet, and by extracting knot flux densities through three filters, we set constraints on emission models. While the radio and optical flux densities are usually explained by synchrotron emission, there are several emission mechanisms that might be used to explain the X-ray flux densities. Our data rule out Doppler-boosted inverse Compton scattering as a source of the high-energy emission. Instead, we find that the observed emission can be well described by synchrotron emission from electrons with a low-energy index (p ∼ 2) that dominates the radio band, while a high-energy index (p ∼ 3) is needed for the X-ray band and the transition occurs in the optical/infrared band. This model is consistent with a continuous electron injection scenario.Peer reviewedFinal Accepted Versio

Functional biology of the Steel syndrome founder allele and evidence for clan genomics derivation of COL27A1 pathogenic alleles worldwide

© 2020, The Author(s). Previously we reported the identification of a homozygous COL27A1 (c.2089G\u3eC; p.Gly697Arg) missense variant and proposed it as a founder allele in Puerto Rico segregating with Steel syndrome (STLS, MIM #615155); a rare osteochondrodysplasia characterized by short stature, congenital bilateral hip dysplasia, carpal coalitions, and scoliosis. We now report segregation of this variant in five probands from the initial clinical report defining the syndrome and an additional family of Puerto Rican descent with multiple affected adult individuals. We modeled the orthologous variant in murine Col27a1 and found it recapitulates some of the major Steel syndrome associated skeletal features including reduced body length, scoliosis, and a more rounded skull shape. Characterization of the in vivo murine model shows abnormal collagen deposition in the extracellular matrix and disorganization of the proliferative zone of the growth plate. We report additional COL27A1 pathogenic variant alleles identified in unrelated consanguineous Turkish kindreds suggesting Clan Genomics and identity-by-descent homozygosity contributing to disease in this population. The hypothesis that carrier states for this autosomal recessive osteochondrodysplasia may contribute to common complex traits is further explored in a large clinical population cohort. Our findings auNorthwell Healthnt our understanding of COL27A1 biology and its role in skeletal development; and expand the functional allelic architecture in this gene underlying both rare and common disease phenotypes

A Deep HST H-Band Imaging Survey of Massive Gas-Rich Mergers. II. The QUEST PG QSOs

We report the results from a deep HST NICMOS H-band imaging survey of 28 z < 0.3 QSOs from the Palomar-Green (PG) sample. This program is part of QUEST (Quasar / ULIRG Evolution STudy) and complements a similar set of data on 26 highly-nucleated ULIRGs presented in Paper I. Our analysis indicates that the fraction of QSOs with elliptical hosts is higher among QSOs with undetected far-infrared (FIR) emission, small infrared excess, and luminous hosts. The hosts of FIR-faint QSOs show a tendency to have less pronounced merger-induced morphological anomalies and larger QSO-to-host luminosity ratios on average than the hosts of FIR-bright QSOs, consistent with late-merger evolution from FIR-bright to FIR-faint QSOs. The spheroid sizes and total host luminosities of the radio-quiet PG QSOs in our sample are statistically indistinguishable from the ULIRG hosts presented in Paper I, while those of radio-loud PG QSOs are systematically larger and more luminous. ULIRGs and PG QSOs with elliptical hosts fall near, but not exactly on, the fundamental plane of inactive spheroids. We confirm the systematic trend noted in Paper I for objects with small (< 2 kpc) spheroids to be up to ~1 mag. brighter than inactive spheroids. The host colors and wavelength dependence of their sizes support the idea that these deviations are due at least in part to non-nuclear star formation. However, the amplitudes of these deviations does not depend on host R-H colors. Taken at face value (i.e., no correction for extinction or the presence of a young stellar population), the H-band spheroid-host luminosities imply BH masses ~5 -- 200 x 10^7 M_sun and sub-Eddington mass accretion rates for both QSOs and ULIRGs. These results are compared with published BH mass estimates derived from other methods. (abridged)Comment: Accepted for publication in the Astrophysical Journal, Vol. 701, August 20 issue. Paper with high-resolution figures can be downloaded at http://www.astro.umd.edu/~veilleux/pubs/nicmos2.pd

Ordinacions tocants a la custodia y guarda de la costa maritima del Regne de Valencia ... [Texto impreso]

Sign.: A-F4, G5Port. con orla tipTexto con apostillas marginale