Museo Arqueológico Municipal de Jerez de la Frontera. Una historia de luces y sombras

El Museo Arqueológico Municipal de Jerez de la Frontera tiene una larga trayectoria. Su origen se encuentra en el Depósito Municipal de Antigüedades creado en la ciudad a mediados del siglo XVIII, el más antiguo de estas características del que se tiene constancia en Andalucía. Su recorrido no es lineal, sino fluctuante, con periodos inciertos y otros de gran brillantez. Se puede ordenar en varios apartados: formación del Depósito de Antigüedades, Colección Arqueológica, que abarca grosso modo desde mediados del siglo XVIII hasta mediados del siglo XX; constitución del Museo Arqueológico Municipal en 1962; traslado y apertura de nueva sede en 1992, y ampliación y reforma en la primera década del siglo XXI

Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aorta

Orujo' olive oil is obtained by chemical processes from the waste resulting from the mechanical extraction of virgin olive oil. The aim of the present study was to evaluate a new pharmacological property of two natural triterpenoids contained in olive oil, as vasodilatory agents, and to determine their mechanism of action. The two compounds studied were oleanolic acid and erythrodiol. The vasorelaxant effect induced by these pentacyclic triterpenoids was studied in isolated thoracic rat aorta. Oleanolic acid and erythrodiol, accumulatively added, showed vasorelaxant activities in aortic rings with endothelium pre-contracted by 10-6 M-phenylephrine (maximum percentage of relaxation 86.38 (SEM 2.89) and 73.53 (SEM 6.01), respectively). They had almost no relaxant effect on depolarised or endothelium-denuded aortic segments. The relaxation was significantly attenuated by pre-treatment with the NO synthase inhibitor Nω -nitro-L-argi-nine-methylester (L-NAME; 3 × 10-4 M). To characterise the involvement of endothelial factors, in addifion to NO, arteries with endothelium were exposed to 10-5 M-indomethacin (INDO), a cyclo-oxygenase inhibitor, or INDO plus L-NAME. INDO did not have any significant effect on the relaxant response of both compounds. The combination of L-NAME plus INDO only abolished the oleanolic acid-induced relaxation. The present results suggest that the mechanism of relaxation seems to be mainly mediated by the endothelial production of NO; however, other mechanisms cannot be excluded. It can be concluded that oleanolic acid and erythrodiol may have interesting therapeutic potential as new vasodilator drugs, thus protecting the cardiovascular system. Therefore, the intake of 'orujo' olive oil, as a source of these compounds, might be beneficial in this regard.Comisión Interministerial de Ciencia y Tecnología AGL2002-00195Junta de Andalucía CAO01-00

Effects of pomace olive oil-enriched diets on endothelial function of small mesenteric arteries from spontaneously hypertensive rats

Pomace olive oil (POM), an olive oil subproduct traditionally used in Spain, is a good source of minor components from the unsaponifiable fraction such as triterpenoids, mainly in the form of oleanolic acid, which induces vascular protection and vasodilatation. Our aim was to evaluate the effects of long-term intake of diets enriched in POM with high concentration in oleanolic acid on endothelial dysfunction associated to hypertension in small mesenteric arteries (SMA) from spontaneously hypertensive rats (SHR). During 12 weeks, rats (six rats per group) were fed either a control 2% maize oil diet (BD), or high-fat diets containing 15% refined olive oil (OL), pomace olive oil (POM), or pomace olive oil supplemented in oleanolic acid (POMO; up to 800 parts per million). Endothelial and vascular functions were assessed by relaxing or contracting responses to acetylcholine (ACh) or phenylephrine, respectively. The involvement of endothelium-derived relaxing factors in these responses was evaluated. In contrast to BD, SHR fed high-fat diets showed a biphasic response to ACh related to changes in eicosanoid metabolism. POM enhanced the endothelial function in SMA from SHR by increasing the endothelium-derived hyperpolarising factor (EDHF)-type component, whereas administration of POMO resulted in a similar contribution of NO/EDHF in the endothelial response to ACh. The present study shows that despite the lack of changes in blood pressure, consumption of POM improves endothelial function in SMA from SHR by improving the agonist-mediated EDHF/NO response. Thus, triterpenoids confer a protective role to POM against endothelial dysfunction in hypertension.Comision Interministerial de Ciencia y Tecnologia AGR163Junta de Andalucia AGL2005-00 572, AGL2008-022845/ALIFondo de Investigaciones Sanitarias ISCIII G03/140-200

Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice

Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean dietSpanish Ministerio de Economía, Industria y Competitividad (MINECO), Agencia Estatal de Investigación (AEI), and Fondo Europeo de Desarrollo Regional (FEDER) (Grants SAF2017-82813-C3-3-R and PCI2018-092997/AEI to R.R.-R.

Eficacia del contacto e información como técnicas de cambio de actitudes hacia personas con discapacidad en niños de Educación Primaria

Universitas Psychologica, vol. 12, no. 3, pp. 493-504Las actitudes negativas hacia las personas con discapacidad imperantes en la sociedad plantean la necesidad de intervenciones que modifiquen tales actitudes. Con este objetivo se ha desarrollado un programa de cambio de actitudes hacia personas con discapacidad en alumnos de educación primaria, 100 niños y niñas, entre 7 y 10 años, asignados 39 al grupo experimental y 61 al grupo control. Se utilizaron como técnicas de cambio la información y el contacto. También se efectuó un seguimiento de dos años y medio, durante el que se realizaron actividades recordatorio. El instrumento de evaluación utilizado fue la Escala de Actitudes hacia Personas con Discapacidad (Verdugo, Arias & Jenaro, 1994). Los resultados alcanzados abogan por la eficacia de estas técnicas, al encontrase entre las medidas pretratamiento y postratamiento diferencias estadísticamente significativas para estas últimas a favor del grupo experimental. Tales cambios se mantienen en el seguimiento

Electrical properties of reduced 3YTZP ceramics consolidated by spark plasma sintering

3 mol% Yttria doped zirconia ceramics were consolidated by spark plasma sintering (SPS) at two sintering temperatures with the aim of achieving two different reduction levels. Microstructural characterization of the ceramics was performed by scanning electron microscopy (SEM). Electrical properties were investigated by means of impedance spectroscopy from room temperature up to 500 °C. The two ceramics presented a remarkably different electrical behavior. The effect of the extra electrons introduced by reduction during SPS on both the bulk and the grain boundary conductivity was analyzed and discussed.España Mineco MAT2009-11078 MAT2012-34217Junta de Andalucia P12-FQM-107