FACTORES DE RIESGO PSICOSOCIAL Y ESTADO DE SALUD MENTAL EN SERVIDORES PÚBLICOS SINDICALIZADOS DEL MUNICIPIO DE GUADALAJARA

Los factores de riesgo psicosocial son aquellos que pueden provocar afectaciones a la salud mental de los trabajadores, por este motivo, el objetivo de este estudio ha sido evaluar la asociación de los factores de riesgo psicosocial y salud mental en una muestra de 163 servidores públicos sindicalizados del municipio de Guadalajara por medio de un estudio observacional con diseño transversal analítico. Los instrumentos del presente estudio fueron el “Cuestionario de Factores Psicosociales en el Trabajo” por Silva-Gutiérrez B. N. y el “Cuestionario General de Salud GHQ 28”. Los resultados obtenidos muestran una asociación significativa entre contenido y características de la tarea con ansiedad-insomnio, y exigencias laborales con disfunción social. Actualmente, los estudios referentes a los servidores públicos carecen de preponderancia debido al interés centrado en personal médico y de enfermería, por lo cual, es necesario realizar investigaciones en la población de servidores públicos, así como realizar programas de promoción de la salud que recomienda la Organización Mundial de la Salud

Validation and Selection of New Reference Genes for RT-qPCR Analysis in Pediatric Glioma of Different Grades

Gliomas are heterogeneous, solid, and intracranial tumors that originate from glial cells. Malignant cells from the tumor undergo metabolic alterations to obtain the energy required for proliferation and the invasion of the cerebral parenchyma. The alterations in the expression of the genes related to the metabolic pathways can be detected in biopsies of gliomas of different CNS WHO grades. In this study, we evaluated the expression of 16 candidate reference genes in the HMC3 microglia cell line. Then, statistical algorithms such as BestKeeper, the comparative ΔCT method, geNorm, NormFinder, and RefFinder were applied to obtain the genes most suitable to be considered as references for measuring the levels of expression in glioma samples. The results show that PKM and TPI1 are two novel genes suitable for genic expression studies on gliomas. Finally, we analyzed the expression of genes involved in metabolic pathways in clinical samples of brain gliomas of different CNS WHO grades. RT-qPCR analysis showed that in CNS WHO grade 3 and 4 gliomas, the expression levels of HK1, PFKM, GAPDH, G6PD, PGD1, IDH1, FASN, ACACA, and ELOVL2 were higher than those of CNS WHO grade 1 and 2 glioma biopsies. Hence, our results suggest that reference genes from metabolic pathways have different expression profiles depending on the stratification of gliomas and constitute a potential model for studying the development of this type of tumor and the search for molecular targets to treat gliomas

Measurement of the dependence of the hadron production fraction ratio fs/fuf_\mathrm{s} / f_\mathrm{u} and fd/fuf_\mathrm{d} / f_ \mathrm{u} on B meson kinematic variables in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceThe dependence of the ratio between the B$_\mathrm{s}^0$ and B$^+$ hadron production fractions, $f_\mathrm{s} / f_\mathrm{u}$, on the transverse momentum ($p_\mathrm{T}$) and rapidity of the B mesons is studied using the decay channels B$_\mathrm{s}^0$$\to$ J$/\psi\,\phi$ and B$^+$$\to$ J$/\psi$ K$^+$. The analysis uses a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the CMS experiment in 2018 and corresponding to an integrated luminosity of 61.6 fb$^{-1}$. The $f_\mathrm{s} / f_\mathrm{u}$ ratio is observed to depend on the B $p_\mathrm{T}$ and to be consistent with becoming asymptotically constant at large $p_\mathrm{T}$. No rapidity dependence is observed. The ratio of the B$^0$ to B$^+$ hadron production fractions, $f_\mathrm{d} / f_\mathrm{u}$, measured using the B$^0$$\to$ J$/\psi$ K$^{*0}$ decay channel, is found to be consistent with unity and independent of $p_\mathrm{T}$ and rapidity, as expected from isospin invariance

Search for a new resonance decaying into two spin-0 bosons in a final state with two photons and two bottom quarks in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceA search for a new boson X is presented using CERN LHC proton-proton collision data collected by the CMS experiment at $\sqrt{s}$ = 13 TeV in 2016-2018, and corresponding to an integrated luminosity of 138 fb$^{-1}$. The resonance X decays into either a pair of Higgs bosons HH of mass 125 GeV or an H and a new spin-0 boson Y. One H subsequently decays to a pair of photons, and the second H or Y, to a pair of bottom quarks. The explored mass ranges of X are 260-1000 GeV and 300-1000 GeV, for decays to HH and to HY, respectively, with the Y mass range being 90-800 GeV. For a spin-0 X hypothesis, the 95% confidence level upper limit on the product of its production cross section and decay branching fraction is observed to be within 0.90-0.04 fb, depending on the masses of X and Y. The largest deviation from the background-only hypothesis with a local (global) significance of 3.8 (2.8) standard deviations is observed for X and Y masses of 650 and 90 GeV, respectively. The limits are interpreted using several models of new physics

Multiplicity and transverse momentum dependence of charge-balance functions in pPb and PbPb collisions at LHC energies

International audienceMeasurements of the charge-dependent two-particle angular correlation function in proton-lead (pPb) collisions at a nucleon-nucleon center-of-mass energy of $\sqrt{s_\mathrm{NN}}$ = 8.16 TeV and lead-lead (PbPb) collisions at$\sqrt{s_\mathrm{NN}}$ = 5.02 TeV are reported. The pPb and PbPb datasets correspond to integrated luminosities of 186\nbinv and 0.607 nb$^{-1}$, respectively, and were collected using the CMS detector at the CERN LHC. The charge-dependent correlations are characterized by balance functions of same- and opposite-sign particle pairs. The balance functions, which contain information about the creation time of charged particle pairs and the development of collectivity, are studied as functions of relative pseudorapidity ($\Delta \eta$) and relative azimuthal angle ($\Delta \phi$), for various multiplicity and transverse momentum ($p_\mathrm{T}$) intervals. A multiplicity dependence of the balance function is observed in $\Delta \eta$ and $\Delta \phi$ for both systems. The width of the balance functions decreases towards high-multiplicity collisions in the momentum region $\lt$2 GeV, for pPb and PbPb results. No multiplicity dependence is observed at higher transverse momentum. The data are compared with HYDJET, HIJING and AMPT generator predictions, none of which capture completely the multiplicity dependence seen in the data

Search for resonances in events with photon and jet final states in proton-proton collisions at s\sqrt{s}= 13 TeV

International audienceA search for resonances in events with the $\gamma$+jet final state has been performed using proton-proton collision data collected at $\sqrt{s}$= 13 TeV by the CMS experiment at the LHC. The total data analyzed correspond to an integrated luminosity of 138 fb$^{-1}$. Models of excited quarks and quantum black holes are considered. The invariant mass spectrum of the $\gamma$+jet system is examined for the presence of resonances over the standard model continuum background. The data exhibit no statistically significant deviations from the expected standard model background. Exclusion limits at 95% confidence level on the resonance mass and other parameters are set. Excited light-flavor quarks (excited bottom quarks) are excluded up to a mass of 6.0 (3.8) TeV. Quantum black hole production is excluded for masses up to 7.5 (5.2) TeV in the Arkani-Hamed-Dimopoulos-Dvali (Randall-Sundrum) model. These lower mass bounds are the most stringent to date among those obtained in the $\gamma$+jet final state

Search for top squark pair production in a final state with at least one hadronically decaying tau lepton in proton-proton collisions at s \sqrt{s} = 13 TeV

A search for pair production of the supersymmetric partner of the top quark, the top squark, in proton-proton collisions at $\sqrt{s}$ = 13 TeV is presented in final states containing at least one hadronically decaying tau lepton and large missing transverse momentum. This final state is highly sensitive to scenarios of supersymmetry in which the decay of the top squark to tau leptons is enhanced. The search uses a data sample corresponding to an integrated luminosity of 138 fb$^{−1}$, which was recorded with the CMS detector during 2016–2018. No significant excess is observed with respect to the standard model predictions. Exclusion limits at 95% confidence level on the masses of the top squark and the lightest neutralino are presented under the assumptions of simplified models. The results probe top squark masses up to 1150 GeV for a nearly massless neutralino. This search covers a relatively less explored parameter space in the context of supersymmetry, and the exclusion limit is the most stringent to date for the model considered here.[graphic not available: see fulltext

Performance of the local reconstruction algorithms for the CMS hadron calorimeter with Run 2 data

International audienceA description is presented of the algorithms used to reconstruct energy deposited in the CMS hadron calorimeter during Run 2 (2015-2018) of the LHC. During Run 2, the characteristic bunch-crossing spacing for proton-proton collisions was 25 ns, which resulted in overlapping signals from adjacent crossings. The energy corresponding to a particular bunch crossing of interest is estimated using the known pulse shapes of energy depositions in the calorimeter, which are measured as functions of both energy and time. A variety of algorithms were developed to mitigate the effects of adjacent bunch crossings on local energy reconstruction in the hadron calorimeter in Run 2, and their performance is compared

Measurement of simplified template cross sections of the Higgs boson produced in association with W or Z bosons in the H →\tobbˉ\mathrm{b\bar{b}} decay channel in proton-proton collisions at s\sqrt{s} =13 TeV

International audienceDifferential cross sections are measured for the standard model Higgs boson produced in association with vector bosons (W, Z) and decaying to a pair of b quarks. Measurements are performed within the framework of the simplified template cross sections. The analysis relies on the leptonic decays of the W and Z bosons, resulting in final states with 0, 1, or 2 electrons or muons. The Higgs boson candidates are either reconstructed from pairs of resolved b-tagged jets, or from single large distance parameter jets containing the particles arising from two b quarks. Proton-proton collision data at $\sqrt{s}$ = 13 TeV, collected by the CMS experiment in 2016-2018 and corresponding to a total integrated luminosity of 138 fb$^{-1}$, are analyzed. The inclusive signal strength, defined as the product of the observed production cross section and branching fraction relative to the standard model expectation, combining all analysis categories, is found to be $\mu$ = 1.15$^{+0.22}_{-0.20}$. This corresponds to an observed (expected) significance of 6.3 (5.6) standard deviations

Two-particle Bose-Einstein correlations and their Lévy parameters in PbPb collisions at sNN\sqrt{s_\mathrm{NN}} = 5.02 TeV

International audienceTwo-particle Bose-Einstein momentum correlation functions are studied for charged-hadron pairs in lead-lead collisions at a center-of-mass energy per nucleon pair of $\sqrt{s_\mathrm{NN}}$ = 5.02 TeV. The data sample, containing 4.27$\times10^{9}$ minimum bias events corresponding to an integrated luminosity of 0.607 nb$^{-1}$, was collected by the CMS experiment in 2018. The experimental results are discussed in terms of a Lévy-type source distribution. The parameters of this distribution are extracted as functions of particle pair average transverse mass and collision centrality. These parameters include the Lévy index or shape parameter ($\alpha$), the Lévy scale parameter ($R$), and the correlation strength parameter ($\lambda$). The source shape, characterized by $\alpha$, is found to be neither Cauchy nor Gaussian, implying the need for a full Lévy analysis. Similarly to what was previously found for systems characterized by Gaussian source radii, a hydrodynamical scaling is observed for the Lévy $R$ parameter. The $\lambda$ parameter is studied in terms of the core-halo model