Generalized Lymphadenopathy: Unusual Presentation of Prostate Adenocarcinoma

Generalized lymphadenopathy is a rare manifestation of metastatic prostate cancer. Here, we report the case of a 59-year-old male patient with supraclavicular, mediastinal, hilar, and retroperitoneal and inguinal lymphadenopathy, which suggested the diagnosis of lymphoma. There were no urinary symptoms. A biopsy of the inguinal lymph node was compatible with adenocarcinoma, whose prostatic origin was shown by immunohistochemical staining with PSA. The origin of the primary tumor was confirmed by directed prostate biopsy. We emphasize that a suspicion of prostate cancer in men with adenocarcinoma of undetermined origin is important for an adequate diagnostic and therapeutic approach

Tumor homing to the oral cavity after tooth extraction in a patient with metastatic lung adenocancer: A case report

Angiogenesis plays a major role not only in the growth of the primary tumor, but also in metastasis. Due to the angiogenesis in granulation tissue, the tumor cells easily migrate to and locate in this region, thereby accelerating the pathological angiogenesis process and proliferation via presence of the angiogenesis-stimulating factors in this site. In this case report, we present tumor homing to granulation tissue following tooth extraction in a 68-year-old male patient with metastatic lung adenocarcinoma. He applied to hospital due to delayed wound healing after tooth extraction for tooth decay approximately 5 months after the diagnosis. A superficially swollen mass of 6 × 6 cm was detected in the tooth extraction site. The histopathological examination suggested that it was a lung carcinoma metastasis. The presence of tooth extraction history together with the pulmonary adenocarcinoma metastasis in the extraction site was explained as “tumoral homing” to granulation tissue following tooth extraction. This patient is of significance since it is the first case in the literature with “tumor homing” observed in the granulation tissue following tooth extraction

Two cases of esophageal eosinophilia: eosinophilic esophagitis or gastro-esophageal reflux disease?

Eosinophilic esophagitis (EoE) and gastro-esophageal reflux disease are among the major causes of isolated esophageal eosinophilia. Isolated esophageal eosinophilia meeting criteria for EoE may respond to proton pump inhibitor (PPI) treatment. This entity is termed <em>proton pumps inhibitor responsive esophageal eosinophilia</em> (PPI-REE). Gastro-esophageal reflux is thought to comprise a subgroup of patients with PPI-REE. According to the latest guidelines, PPI responsiveness distinguishes people with PPI-REE from patients having EoE (non-responders). In this report, two unusual cases with findings belonging to both EoE and PPI-REE are discussed with known and unknown facts

The Histopathological Effect of Aloe Vera on the Wound Healing Process in a Surgically Created Tubularized Incised Plate Urethroplasty Model on Rats

Background Hypospadias is a common congenital anomaly which is determined as an abnormal urethral opening on the ventral face of penis. The purpose of this rat model study was to research the effect of topically applied Aloe vera after a tubularized incised plate urethroplasty (TIPU). Methods The TIPU model was applied to male Wistar albino rats. A total of 30 rats were randomly grouped into 3 groups of 10. Group I was assigned as the control group, treated with 0.9% saline only twice a day for 15 days. Group II received topical Aloe vera gel once a day and Group III received Aloe vera gel twice a day. Spongiofibrosis was graded as 0: none, 1+:≤10% tissues involved, 2+:10%-49% tissues involved, 3+: ≥ 50% tissues involved. Results A higher degree of fibrosis and inflammation was determined in the Group I subjects than in Groups II and III. Fibrosis of grade 3+ was observed in 33% of the control group and not in any of the two Aloe groups (p = 0.043). Inflammation of grade 3+ was seen in 66.7% of the control group, in 10% of Group II, and in 33% of Group III (p = 0.02). Conclusions The topical application of Aloe vera to a surgically created tubularized incised plate urethroplasty model decreased inflammation and fibrosis that may affect the success rates of this operation