Testing the viability of the interacting holographic dark energy model by using combined observational constraints

Using the data coming from the new 182 Gold type Ia supernova samples, the shift parameter of the Cosmic Microwave Background given by the three-year Wilkinson Microwave Anisotropy Probe observations, and the baryon acoustic oscillation measurement from the Sloan Digital Sky Survey, $H(z)$ and lookback time measurements, we have performed a statistical joint analysis of the interacting holographic dark energy model. Consistent parameter estimations show us that the interacting holographic dark energy model is a viable candidate to explain the observed acceleration of our universe.Comment: 15 pages, 9 figures, accepted for publication in JCA

A Note on Temperature and Energy of 4-dimensional Black Holes from Entropic Force

We investigate the temperature and energy on holographic screens for 4-dimensional black holes with the entropic force idea proposed by Verlinde. We find that the "Unruh-Verlinde temperature" is equal to the Hawking temperature on the horizon and can be considered as a generalized Hawking temperature on the holographic screen outside the horizons. The energy on the holographic screen is not the black hole mass $M$ but the reduced mass $M_0$, which is related to the black hole parameters. With the replacement of the black hole mass $M$ by the reduced mass $M_0$, the entropic force can be written as $F=\frac{GmM_0}{r^2}$, which could be tested by experiments.Comment: V4: 13 pages, 4 figures, title changed, discussions for experiments added, accepted by CQ

Constraints on Dark Energy Models from Weak Gravity Conjecture

We study the constraints on the dark energy model with constant equation of state parameter $w=p/\rho$ and the holographic dark energy model by using the weak gravity conjecture. The combination of weak gravity conjecture and the observational data gives $w<-0.7$ at the $3\sigma$ confidence level. The holographic dark energy model realized by a scalar field is in swampland.Comment: 4 two column pages, 3 figures, accepted by Chin. Phys. Let

Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe.

Disturbing mitotic progression via targeted anti-mitotic therapy is an attractive strategy for cancer treatment. Therefore, the exploration and elucidation of molecular targets and pathways in mitosis are critical for the development of anti-mitotic drugs. Here, we show that cell division cycle 5-like (Cdc5L), a pre-mRNA splicing factor, is a regulator of mitotic progression. Depletion of Cdc5L causes dramatic mitotic arrest, chromosome misalignments and sustained activation of spindle assembly checkpoint, eventually leading to mitotic catastrophe. Moreover, these defects result from severe impairment of kinetochore-microtubule attachment and serious DNA damage. Genome-wide gene expression analysis reveals that Cdc5L modulates the expression of a set of genes involved in the mitosis and the DNA damage response. We further found that the pre-mRNA splicing efficiency of these genes were impaired when Cdc5L was knocked down. Interestingly, Cdc5L is highly expressed in cervical tumors and osteosarcoma. Finally, we demonstrate that downregulation of Cdc5L decreases the cell viability of related tumor cells. These results suggest that Cdc5L is a key regulator of mitotic progression and highlight the potential of Cdc5L as a target for cancer therapy

The DArk Matter Particle Explorer mission

The DArk Matter Particle Explorer (DAMPE), one of the four scientific space science missions within the framework of the Strategic Pioneer Program on Space Science of the Chinese Academy of Sciences, is a general purpose high energy cosmic-ray and gamma-ray observatory, which was successfully launched on December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE scientific objectives include the study of galactic cosmic rays up to $\sim 10$ TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the search for dark matter signatures in their spectra. In this paper we illustrate the layout of the DAMPE instrument, and discuss the results of beam tests and calibrations performed on ground. Finally we present the expected performance in space and give an overview of the mission key scientific goals.Comment: 45 pages, including 29 figures and 6 tables. Published in Astropart. Phy