Evaluation of corrosion expansion of reinforced concrete specimen using fiber optical Brillouin sensing technique

This paper investigated the evaluation of the concrete damage degree due to steel bar corrosion for reinforced concrete structures. Brillouin optical fiber time domain analysis (BOTDA) sensors were developed to monitor the steel bar corrosion expansion strain. Electrochemical accelerating experimental results showed the sensors could be used for early detection and the lifelong monitoring. The damage factor was proposed to quantitatively evaluate the concrete damage degree before initial cracking and during the development of cracks. Finite element analysis was performed on concrete specimens to map the monitoring results with the damage factor, which supported the capability of the damage factor

Forum: COVID-19 Dispatches

COVID-19 pandemic is the first truly global crisis in the digital age. With death count worldwide reaching 586,000 merely 7 months after its first outbreak in China in late December 2019 and 13.6 million cases reported in 188 countries and territories as of July 2020, this ongoing pandemic has spread far beyond domain of world health problem to become an unprecedented challenge facing humanity at every level. In addition to causing social and economic disruptions on a scale unseen before, it has turned the world into a site of biopolitical agon where science and reason are forced to betray their impotence against cultish thinking in the planetary endgame depicted in so many dystopian science fictions. It is in this context that this forum offers a set of modest reflections on the current impacts incurred by the COVID-19 virus. Blending ethnographic observations with theory-driven reflections, the five authors address issues made manifest by the crisis across different regions, while keeping their sight on the sociopolitical problems plaguing our life both individually and collectively. Taken together, they provide a grounded documentary for the archive that the COVID-19 virus is making us to construct

Sox10+ adult stem cells contribute to biomaterial encapsulation and microvascularization.

Implanted biomaterials and biomedical devices generally induce foreign body reaction and end up with encapsulation by a dense avascular fibrous layer enriched in extracellular matrix. Fibroblasts/myofibroblasts are thought to be the major cell type involved in encapsulation, but it is unclear whether and how stem cells contribute to this process. Here we show, for the first time, that Sox10+ adult stem cells contribute to both encapsulation and microvessel formation. Sox10+ adult stem cells were found sparsely in the stroma of subcutaneous loose connective tissues. Upon subcutaneous biomaterial implantation, Sox10+ stem cells were activated and recruited to the biomaterial scaffold, and differentiated into fibroblasts and then myofibroblasts. This differentiation process from Sox10+ stem cells to myofibroblasts could be recapitulated in vitro. On the other hand, Sox10+ stem cells could differentiate into perivascular cells to stabilize newly formed microvessels. Sox10+ stem cells and endothelial cells in three-dimensional co-culture self-assembled into microvessels, and platelet-derived growth factor had chemotactic effect on Sox10+ stem cells. Transplanted Sox10+ stem cells differentiated into smooth muscle cells to stabilize functional microvessels. These findings demonstrate the critical role of adult stem cells in tissue remodeling and unravel the complexity of stem cell fate determination

Joint Depth Estimation and Mixture of Rain Removal From a Single Image

Rainy weather significantly deteriorates the visibility of scene objects, particularly when images are captured through outdoor camera lenses or windshields. Through careful observation of numerous rainy photos, we have found that the images are generally affected by various rainwater artifacts such as raindrops, rain streaks, and rainy haze, which impact the image quality from both near and far distances, resulting in a complex and intertwined process of image degradation. However, current deraining techniques are limited in their ability to address only one or two types of rainwater, which poses a challenge in removing the mixture of rain (MOR). In this study, we propose an effective image deraining paradigm for Mixture of rain REmoval, called DEMore-Net, which takes full account of the MOR effect. Going beyond the existing deraining wisdom, DEMore-Net is a joint learning paradigm that integrates depth estimation and MOR removal tasks to achieve superior rain removal. The depth information can offer additional meaningful guidance information based on distance, thus better helping DEMore-Net remove different types of rainwater. Moreover, this study explores normalization approaches in image deraining tasks and introduces a new Hybrid Normalization Block (HNB) to enhance the deraining performance of DEMore-Net. Extensive experiments conducted on synthetic datasets and real-world MOR photos fully validate the superiority of the proposed DEMore-Net. Code is available at https://github.com/yz-wang/DEMore-Net.Comment: 11 pages, 7 figures, 5 table

Halogen Bonding Increases the Potency and Isozyme-selectivity of Protein Arginine Deiminase 1 Inhibitors

Protein Arginine Deiminases (PADs) hydrolyze the side chain of arginine to form citrulline. Aberrant PAD activity is associated with rheumatoid arthritis, multiple sclerosis, lupus, and certain cancers. These pathologies established the PADs as therapeutic targets and multiple PAD inhibitors are known. Herein, we describe the first highly potent PAD1-selective inhibitors (1 and 19). Detailed structure-activity relationships indicate that their potency and selectivity is due to the formation of a halogen bond with PAD1. Importantly, these inhibitors inhibit histone H3 citrullination in HEK293TPAD1 cells and mouse zygotes with excellent potency. Based on this scaffold, we also developed a PAD1-selective activity-based probe that shows remarkable cellular efficacy and proteome selectivity. Based on their potency and selectivity we expect that 1 and 19 will be widely used chemical tools to understand PAD1 biology

Chaos-assisted broadband momentum transformation in optical microresonators

The law of momentum conservation rules out many desired processes in optical microresonators. We report broadband momentum transformations of light in asymmetric whispering gallery microresonators. Assisted by chaotic motions, broadband light can travel between optical modes with different angular momenta within a few picoseconds. Efficient coupling from visible to near-infrared bands is demonstrated between a nanowaveguide and whispering gallery modes with quality factors exceeding 10 million. The broadband momentum transformation enhances the device conversion efficiency of the third-harmonic generation by greater than three orders of magnitude over the conventional evanescent-wave coupling. The observed broadband and fast momentum transformation could promote applications such as multicolor lasers, broadband memories, and multiwavelength optical networks

Brillouin Corrosion Expansion Sensors for Steel Reinforced Concrete Structures Using a Fiber Optic Coil Winding Method

In this paper, a novel kind of method to monitor corrosion expansion of steel rebars in steel reinforced concrete structures named fiber optic coil winding method is proposed, discussed and tested. It is based on the fiber optical Brillouin sensing technique. Firstly, a strain calibration experiment is designed and conducted to obtain the strain coefficient of single mode fiber optics. Results have shown that there is a good linear relationship between Brillouin frequency and applied strain. Then, three kinds of novel fiber optical Brillouin corrosion expansion sensors with different fiber optic coil winding packaging schemes are designed. Sensors were embedded into concrete specimens to monitor expansion strain caused by steel rebar corrosion, and their performance was studied in a designed electrochemical corrosion acceleration experiment. Experimental results have shown that expansion strain along the fiber optic coil winding area can be detected and measured by the three kinds of sensors with different measurement range during development the corrosion. With the assumption of uniform corrosion, diameters of corrosion steel rebars were obtained using calculated average strains. A maximum expansion strain of 6,738 με was monitored. Furthermore, the uniform corrosion analysis model was established and the evaluation formula to evaluate mass loss rate of steel rebar under a given corrosion rust expansion rate was derived. The research has shown that three kinds of Brillouin sensors can be used to monitor the steel rebar corrosion expansion of reinforced concrete structures with good sensitivity, accuracy and monitoring range, and can be applied to monitor different levels of corrosion. By means of this kind of monitoring technique, quantitative corrosion expansion monitoring can be carried out, with the virtues of long durability, real-time monitoring and quasi-distribution monitoring