Wyniki czynnościowe usprawniania chorych po aloplastykach całkowitych stawu biodrowego endoprotezami krótkotrzpieniowymi i przynasadowymi

Wstęp: Aloplastyki całkowite stawu biodrowego z pewnością zajmują już trwałe miejsce w praktyce operacyjnej choroby zwyrodnieniowej, a także uszkodzeń urazowych szyjki kości udowej. Na przestrzeni ostatnich kilkunastu lat coraz większą uwagę skupiają na sobie tzw. endoprotezy przynasadowe i krótkotrzpieniowe, które niosą ze sobą nowe wyzwania operacyjne i rehabilitacyjne. Celem pracy była ocena wyników czynnościowych aloplastyki całkowitej stawów biodrowych z wykorzystaniem endoprotez krótkotrzpieniowych, przynasadowych oraz niecementowanych z trzpieniem standardowym. Projekt badań: Badanie retrospektywne. Materiał badań: Materiał badań pochodzi z lat 1993-2014 i obejmuje 180 operowanych z powodu zwyrodnienia stawów biodrowych metodą aloplastyki całkowitej, w tym 96 endoprotezą niecementowaną z trzpieniem standardowym typu ABG-1, co stanowi 53,4%, 62 endoprotezą przynasadową typu Proxima, co daje 34,4%, 14 endoprotezą krótkotrzpieniową typu BTS, czyli 7,7% oraz 8 endoprotezą z krótkim trzpieniem typu TL, co stanowi 4,4%. Metoda badań: Kilkukrotnie wykonywany test czynnościowy Harrisa. Wyniki badań: Uzyskane wyniki czynnościowe w poszczególnych grupach operowanych są porównywalne i zbieżne, bez wyraźnych różnic. Wnioski: Analizowane aloplastyki całkowite stawów biodrowych u większości operowanych, zarówno w obserwacji wczesnej, jak i odległej, skutkują bardzo dobrymi i dobrymi wynikami czynnościowymi oraz są porównywalne z wynikami aloplastyk całkowitych endoprotezami z trzpieniem standardowym. Operowani analizowanymi metodami nie wymagają odmiennych programu rehabilitacji o odrębnej charakterystyce biomechanicznej i klinicznej.Introduction: Total hip arthroplasty already has a permanent place among surgical procedures dealing with osteoarthritis, as well as traumatic injuries of the femoral neck. In recent years, there has been an increased interest in metaphyseal-fitting and short-stem endoprostheses, which bring new challenges regarding operating technique and rehabilitation care. The aim of this study was to evaluate functional results of total hip arthroplasty using the following endoprostheses: short-stem, metaphyseal-fitting, and cementless with a standard stem. Research Project: Retrospective study. Materials and methods: The research material covers the period between 1993 and 2014 and includes 180 patients operated on due to hip osteoarthritis using total hip arthroplasty. In 96 patients (53.4%) cementless endoprosthesis with a standard ABG-1 stem was used, in 62 patients (34.4%) the Proxima metaphyseal prosthesis was implanted, in 14 patients (7.7%) the BTS short-stem endoprosthesis was used, and in 8 patients (4.4%) TL short-stem endoprosthesis was used. Each patient was evaluated several times using the Harris Hip Score. Results: Functional results obtained in individual groups of patients who underwent surgery are comparable and consistent, without pronounced differences. Conclusions: Functional results obtained in analysed total hip arthroplasties were excellent and good in the majority of patients, both in the early and late observation periods. They are comparable with results of total hip arthroplasties with standard stem endoprosthesis. Patients operated on using the described methods do not require a different rehabilitation programme with different biomechanical or clinical characteristics when compared to patients with standard stem endoprostheses

Jakość życia po złamaniach dalszego końca kości promieniowej

Introduction: Distal radius fractures (DRFs) are among the most commonly seen types of fractures worldwide. Numerous studies suggested that surgical treatment of DRFs results in better quality of life. Objectives: The aim of this study was to assess long-term quality of life after operative and nonoperative treatment of distal radius fractures among adults. Material and methods: We retrospectively studied 207 patients with isolated DRF (mean age 64 ±17.9 years, women comprised 150 (72.5%), men 57 (27.5%). There were no significant differences in sex, age, hand dominancy, energy of trauma, AO type fracture and comorbidities between patients treated operatively (n=101) and nonoperatively (n=106). After 3.9 ±1.6 years (mean ±SD) quality of life assessment was conducted using Short Form Health Survey (SF-36) and International Osteoporosis Foundation Quality of Life Questionnaire (IOF QLQ). Functional outcomes were evaluated using Disabilities of the Arm, Shoulder and Hand (DASH) and Patient Rated Wrist Evaluation (PRWE) questionnaires. Results: Quality of life in operatively treated distal radius fracture patients was better than amongst those treated nonsurgically. However, after subdivision of cohorts we observed no such differences regardless of treatment method in patients aged ≥ 50 years. SF-36 and IOF QLQ scores were correlated with DASH and PRWE results. Conclusions: Quality of life questionnaires are useful tools for determining outcomes after distal radius fractures. Operative treatment may not always be superior to nonoperative management especially in patients aged 50 years or above with distal radius fractures.Wstęp: Złamania dalszego końca kości promieniowej (DKKP) są jednymi z najczęściej spotykanych złamań w skali świata. Liczne badania sugerują, że operacyjne leczenie złamań DKKP jest powiązane z lepszą jakością życia. Cele: Celem pracy była ocena długoterminowej jakości życia po operacyjnym i nieoperacyjnym leczeniu złamań dalszego końca kości promieniowej u osób dorosłych. Materiał imetody: W retrospektywnym badaniu oceniono 207 pacjentów z izolowanym złamaniem DKKP (średni wiek 64 ±17,9 lat, 150 kobiet (72,5%) i 57 mężczyzn (27,5%). Nie stwierdzono istotnych statystycznie różnic w zakresie płci, wieku, kończyny dominującej, energii urazu, typu złamania wg AO i chorobach współistniejących między pacjentami leczonymi operacyjnie (n = 101) i nieoperacyjnie (n = 106). Po 3,9 ±1,6 roku (średnia ± odchylenie standardowe) dokonano oceny jakości życia za pomocą narzędzia Short Form Health Survey (SF-36) oraz International Osteoporosis Foundation Quality of Life Questionnaire (IOF QLQ) Wyniki czynnościowe oceniano za pomocą kwestionariuszy Disabilities of the Arm, Shoulder and Hand (DASH) oraz Patient Rated Wrist Evaluation (PRWE). Wyniki: Jakość życia pacjentów z złamaniami dalszego końca kości promieniowej leczonymi operacyjnie była lepsza niż w grupie leczonej nieoperacyjnie. Jednak u pacjentów w wieku 50 lat nie zaobserwowano istotnych statystycznie różnic w jakości życia niezależnie od metody leczenia. Wyniki SF-36 i IOF QLQ były skorelowane z wynikami DASH i PRWE. Wnioski: Kwestionariusze jakości życia są użytecznymi narzędziami do określania wyników leczenia po złamaniach dalszego końca kości promieniowej. Leczenie operacyjne nie zawsze skutkuje lepszą jakością życia niż postępowanie nieoperacyjne, zwłaszcza u pacjentów w wieku 50 lat i starszych ze złamaniami dalszego końca kości promieniowej

Jakość życia po złamaniach dalszego końca kości promieniowej

Wstęp: Złamania dalszego końca kości promieniowej (DKKP) są jednymi z najczęściej spotykanych złamań w skali świata. Liczne badania sugerują, że operacyjne leczenie złamań DKKP jest powiązane z lepszą jakością życia. Cele: Celem pracy była ocena długoterminowej jakości życia po operacyjnym i nieoperacyjnym leczeniu złamań dalszego końca kości promieniowej u osób dorosłych. Materiał i metody: W retrospektywnym badaniu oceniono 207 pacjentów z izolowanym złamaniem DKKP (średni wiek 64 ±17,9 lat, 150 kobiet (72,5%) i 57 mężczyzn (27,5%). Nie stwierdzono istotnych statystycznie różnic w zakresie płci, wieku, kończyny dominującej, energii urazu, typu złamania wg AO i chorobach współistniejących między pacjentami leczonymi operacyjnie (n = 101) i nieoperacyjnie (n = 106). Po 3,9 ±1,6 roku (średnia ± odchylenie standardowe) dokonano oceny jakości życia za pomocą narzędzia Short Form Health Survey (SF-36) oraz International Osteoporosis Foundation Quality of Life Questionnaire (IOF QLQ) Wyniki czynnościowe oceniano za pomocą kwestionariuszy Disabilities of the Arm, Shoulder and Hand (DASH) oraz Patient Rated Wrist Evaluation (PRWE). Wyniki: Jakość życia pacjentów z złamaniami dalszego końca kości promieniowej leczonymi operacyjnie była lepsza niż w grupie leczonej nieoperacyjnie. Jednak u pacjentów w wieku ≥ 50 lat nie zaobserwowano istotnych statystycznie różnic w jakości życia niezależnie od metody leczenia. Wyniki SF-36 i IOF QLQ były skorelowane z wynikami DASH i PRWE. Wnioski: Kwestionariusze jakości życia są użytecznymi narzędziami do określania wyników leczenia po złamaniach dalszego końca kości promieniowej. Leczenie operacyjne nie zawsze skutkuje lepszą jakością życia niż postępowanie nieoperacyjne, zwłaszcza u pacjentów w wieku 50 lat i starszych ze złamaniami dalszego końca kości promieniowej.Introduction: Distal radius fractures (DRFs) are among the most commonly seen types of fractures worldwide. Numerous studies suggested that surgical treatment of DRFs results in better quality of life. Objectives: The aim of this study was to assess long-term quality of life after operative and nonoperative treatment of distal radius fractures among adults. Material and methods: We retrospectively studied 207 patients with isolated DRF (mean age 64 ±17.9 years, women comprised 150 (72.5%), men 57 (27.5%). There were no significant differences in sex, age, hand dominancy, energy of trauma, AO type fracture and comorbidities between patients treated operatively (n=101) and nonoperatively (n=106). After 3.9 ±1.6 years (mean ±SD) quality of life assessment was conducted using Short Form Health Survey (SF-36) and International Osteoporosis Foundation Quality of Life Questionnaire (IOF QLQ). Functional outcomes were evaluated using Disabilities of the Arm, Shoulder and Hand (DASH) and Patient Rated Wrist Evaluation (PRWE) questionnaires. Results: Quality of life in operatively treated distal radius fracture patients was better than amongst those treated nonsurgically. However, after subdivision of cohorts we observed no such differences regardless of treatment method in patients aged 50 years. SF-36 and IOF QLQ scores were correlated with DASH and PRWE results. Conclusions: Quality of life questionnaires are useful tools for determining outcomes after distal radius fractures. Operative treatment may not always be superior to nonoperative management especially in patients aged 50 years or above with distal radius fractures

Higher Mortality in Men Compared with Women following Distal Radius Fracture in Population Aged 50 Years or Above: Are Common Distal Radius Fracture Classifications Useful in Predicting Mortality?

Introduction. Distal radius fractures (DRF) are one of the most common fractures with growing incidence in developed countries and are a reliable predictor of another osteoporotic fracture. Data concerning DRF mortality are conflicting and vague. Usefulness of common DRF classification systems in predicting mortality is unexplored. Methods. We identified all patients hospitalized between January 1st 2008 and May 30th 2015 with isolated distal radius fracture, aged 50 y/o or above, in a 1st level trauma center in Poland. Fractures were evaluated according to AO, Frykman, and Fernandez classifications. Mortality ratios and long-term survival analysis with Kaplan-Meier estimator and log-rank tests with univariate and multivariate Cox proportional hazards model were used. Results. We enrolled 1308 consecutive patients. The average age of the entire cohort was 72.5 ± 12 years. The study group consisted of 256 men (19.6%) with mean age 66 ± 12 y/o and 1052 women (80.4%) with mean age 74 ± 12 y/o. Men were statistically younger at the time of the fracture than women (p<0.0001). After 1-year follow-up the overall study group mortality ratio was 4.5%, being 2.2-fold higher in men compared to women. In long-term survival analysis, excess men mortality remained significant. Factors associated with higher mortality at any point of the study were age (HR: 1.08, 95%CI: 1.07-1.10, p<0.000001), male sex (HR: 1.92, 95%CI: 1.34-2.77; p<0.001), AO type A (HR: 1.64 95%CI 1.19-2.25, p<0.01), and Frykman type I (HR: 2.12 95%CI: 1.36-3.29, p<0.001). Conclusion. Distal radius fractures are connected with premature mortality. Men have higher mortality compared with women following distal radius fracture in population aged 50 years or above. Simple extra articular fractures classified as AO type A or Frykman type I may be predictors of higher mortality in DRF cohort

Phage-Directed Synthesis of Photoluminescent Zinc Oxide Nanoparticles under Benign Conditions

Biological systems, especially bacteriophages and peptides, are an attractive green alternative to other known methods of nanoparticle synthesis. In this work, for the first time, bacteriophages were employed to synthesize a specific peptide, capable of producing nanoparticles (NPs). Derivatives of M13 bacteriophage exposing a ZnO-binding peptide (TMGANLGLKWPV) on either pIII or pVIII phage coat protein were constructed and used as a biotemplate. The exposition of the ZnO-binding peptide, synthesized by phages during their propagation in bacteria, on M13 virions provided a groundwork for growing ZnO nanostructures. Depending on the recombinant phage type used (M13-pIII-ZnO or M13-pVIII-ZnO), well separated ZnO NPs or complex 3D structures of ZnO NPs of ca. 20-40 nm were synthesized at room temperature. The synthesized ZnO nanoparticles served as a luminescent material that emitted light near the short wavelength end of the visible region (at ca. 400 nm). The next very low intensity emission band at 530 nm demonstrated that the ZnO material obtained is characterized by a low concentration of surface defect

Bacteriophages as Factories for Eu2O3 Nanoparticle Synthesis

The use of phage display to identify peptides with an ability to bind and synthesize Eu2O3 nanoparticles is demonstrated in this report. This is the first report of modified phages specifically binding a lanthanide. The peptides exposed on virions revealed very strong binding to Eu2O3 nanoparticles and the ability to catalyze Eu2O3 nanoparticles' formation from Eu(OH)3 and Eu(NO3)3 solutions. The luminescence emission spectrum of Eu3+ ions indicated that these ions existed mostly in sites deviated from the inversion symmetry in crystalline Eu2O3 aggregates and gelatinous Eu(OH)3 precipitate. The ability of phage-displayed peptides to catalyze formation of Eu2O3 nanoparticles provides a useful tool for a low-cost and effective synthesis of lanthanide nanoparticles, which serve as attractive biomedical sensors or fluorescent labels, among their other applications

Modelling particle deagglomeration in a batch homogenizer using full CFD and mechanistic models

Modelling of titanium dioxide deagglomeration in the mixing tank equipped with a high shear impeller is presented in this study. A combination of computational fluid dynamics with population balance was applied for prediction of the final particle size. Two approaches are presented to solve population balance equations. In the first one, a complete population balance breakage kinetics were implemented in the CFD code to simulate size changes in every numerical cell in the computational domain. The second approach uses flow field and properties of turbulence to construct a mechanistic model of suspension flow in the system. Such approach can be considered as an attractive alternative to CFD simulations, because it allows to greatly reduce time required to obtain the results, i.e., the final particle size distribution of the product. Based on experiments shattering breakage mechanism was identified. A comparison of the mechanistic model and full CFD does not deviate from each other. Therefore the application of a much faster mechanistic model has comparable accuracy with full CFD. The model of particle deagglomeration does not predict a very fast initial drop of particle size, observed in the experiment, but it can predict, with acceptable accuracy, the final particle size of the product

The Antibody Response to the BNT162b2 mRNA COVID-19 Booster in Healthcare Workers: Association between the IgG Antibody Titers and Anthropometric and Body Composition Parameters

Background: Research shows that in most people, two-dose vaccination helps to shape the humoral response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Further studies are required to learn about the vaccine&rsquo;s effectiveness after boosting. Methods: We conducted a prospective study among 103 healthcare workers (HCWs) from a regional multi-specialty hospital vaccinated with three doses of the BNT162b2 vaccine. We compared their immunoglobulin G (IgG) titers 14 days after the second dose with those 21 days after the booster. We also compared their anthropometric and body composition parameters with IgG concentrations at the same time points. Results: Twenty-one days after the booster, all study participants were seropositive. Their mean IgG antibody titers were significantly lower than 14 days after the second dose (158.94 AU/mL &plusmn; 90.34 AU/mL vs. 505.79 AU/mL &plusmn; 367.16 AU/mL). Post-booster Spearman&rsquo;s correlation analysis showed a significantly weak correlation between the IgG antibody titer and parameters related to muscle tissue and adipose tissue (including body fat mass). Conclusions: The BNT162b2 booster stimulates the humoral response to a lesser extent than the two-dose BNT162b2 primary vaccination. The adipose and muscle tissue parameters show a weak positive correlation with the SARS-CoV-2 IgG antibody titers