3,458 research outputs found

    New Veterans Legislation Opens the Door to Judicial Review...Slowly!

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    Tardigrade small heat shock proteins can limit desiccation-induced protein aggregation

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    Small heat shock proteins (sHSPs) are chaperones with well-characterized roles in heat stress, but potential roles for sHSPs in desiccation tolerance have not been as thoroughly explored. We identified nine sHSPs from the tardigrade Hypsibius exemplaris, each containing a conserved alpha-crystallin domain flanked by disordered regions. Many of these sHSPs are highly expressed. Multiple tardigrade and human sHSPs could improve desiccation tolerance of E. coli, suggesting that the capacity to contribute to desicco-protection is a conserved property of some sHSPs. Purification and subsequent analysis of two tardigrade sHSPs, HSP21 and HSP24.6, revealed that these proteins can oligomerize in vitro. These proteins limited heat-induced aggregation of the model enzyme citrate synthase. Heterologous expression of HSP24.6 improved bacterial heat shock survival, and the protein significantly reduced heat-induced aggregation of soluble bacterial protein. Thus, HSP24.6 likely chaperones against protein aggregation to promote heat tolerance. Furthermore, HSP21 and HSP24.6 limited desiccation-induced aggregation and loss of function of citrate synthase. This suggests a mechanism by which tardigrade sHSPs promote desiccation tolerance, by limiting desiccation-induced protein aggregation, thereby maintaining proteostasis and supporting survival. These results suggest that sHSPs provide a mechanism of general stress resistance that can also be deployed to support survival during anhydrobiosis.Small heat shock proteins from the tardigrade Hypsibius exemplaris are shown to provide a mechanism of stress resistance that can support not just heat tolerance but desiccation tolerance as well

    Clustering-Based Materialized View Selection in Data Warehouses

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    Materialized view selection is a non-trivial task. Hence, its complexity must be reduced. A judicious choice of views must be cost-driven and influenced by the workload experienced by the system. In this paper, we propose a framework for materialized view selection that exploits a data mining technique (clustering), in order to determine clusters of similar queries. We also propose a view merging algorithm that builds a set of candidate views, as well as a greedy process for selecting a set of views to materialize. This selection is based on cost models that evaluate the cost of accessing data using views and the cost of storing these views. To validate our strategy, we executed a workload of decision-support queries on a test data warehouse, with and without using our strategy. Our experimental results demonstrate its efficiency, even when storage space is limited

    I found your address in a fortune cookie : a novel

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    I Found Your Address in a Fortune Cookie is a short novel documenting a man's life from childhood to death-bed. It is structured as a series of fragments that, while not strictly chronological, play off one another to create an emotional landscape. The narrative voice shifts between the first and third person. Although going about his life with the semblance of routine, Joshua, the protagonist, is thirsting for something unnamable. His desire runs from mundane, sensual pleasures like lying in bed or drinking coffee to desires for which there are no easy names, like the desire to escape the body. The novel is composed of a series of romantic relationships that span Joshua's early adolescence to his middle age. Approaching death, he withdraws into a dream world in which the messiah has arrived; but even salvation offers little in the way of providing a bottom line to existence. The messianic age proves only to be a continuance of the mundane

    Introducing World Literature into a Vietnam War History Course

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    The author expresses in this essay his conviction of the usefulness of literature –in this case the Vietnam War imaginative literature– as a tool for social sciences. His points of view are supported on the experience of teaching for several years the history of the war and including literaty texts as documents related to the conflict
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