88 research outputs found
Π£ΡΡΠΎΠΉΡΠΈΠ²ΠΎΠ΅ Π²ΠΎΠ΄ΠΎΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΠ΅ ΠΈ Π³Π΅ΠΎΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ (Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΠΠ°ΠΏΠ°Π΄Π½ΠΎΠΉ Π‘ΠΈΠ±ΠΈΡΠΈ)
ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠ½ΠΎΠ³ΠΎΠ»Π΅ΡΠ½ΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ°ΠΊΡΠΎΡΠΎΠ², ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΠΈΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ Π²ΠΎΠ΄Π½ΡΡ
ΡΠ΅ΡΡΡΡΠΎΠ², ΠΈ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΏΡΠΈΡΠΎΠ΄Π½ΡΡ
Π²ΠΎΠ΄. ΠΡ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Ρ ΡΠ»Π΅ΠΌΠ΅Π½ΡΡ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΈ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ Π³Π΅ΠΎΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ Ρ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅Π½Π½ΠΎ-ΠΏΠΈΡΡΠ΅Π²ΠΎΠ³ΠΎ Π²ΠΎΠ΄ΠΎΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ Π² ΠΠ°ΠΏΠ°Π΄Π½ΠΎΠΉ Π‘ΠΈΠ±ΠΈΡΠΈ. ΠΠ½Π° ΡΡΠΈΡΡΠ²Π°Π΅Ρ Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ-ΠΏΡΠΈΡΠΎΠ΄Π½ΡΠ΅ (Π»Π°Π½Π΄ΡΠ°ΡΡΠ½ΠΎ-ΠΊΠ»ΠΈΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅, Π³ΠΈΠ΄ΡΠΎΠ³Π΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅, ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ Π΄Ρ.), ΡΠ΅Ρ
Π½ΠΎΠ³Π΅Π½Π½ΡΠ΅ (ΡΠΌΠΈΡΡΠΈΡ Π·Π°Π³ΡΡΠ·Π½ΡΡΡΠΈΡ
Π²Π΅ΡΠ΅ΡΡΠ², Π³ΠΈΠ΄ΡΠΎΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΎΠΎΡΡΠΆΠ΅Π½ΠΈΡ, Π΄ΠΎΠ±ΡΡΠ° ΡΠ½Π΅ΡΠ³ΠΎΡΠ΅ΡΡΡΡΠΎΠ² ΠΈ Π΄Ρ.) ΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ (ΡΡΠΎΠ²Π΅Π½Ρ ΡΡΠ±Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ, ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΠΎΠ΅ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΈ Π΄Ρ.) ΡΠ°ΠΊΡΠΎΡΡ.The article deals with long-term studies of factors determining the state of water resources, and trends in the quality of natural water. The concept of providing geoecological safety of domestic and drinking water consumption in Western Siberia is described. It takes into account the natural (landscapeclimatic, hydro-geological, ecological, etc.), technogenic (emission of pollutants, hydraulic structures, extraction of energy resources, etc.) and socio-economic (level of urbanization, financial provision, etc.) factors
Mentoring in students' adaptation to labor market requirements
The article contains the analyzes of the problems of youth employment, the development of mentoring in Russia. The ways of their joint decision are proposed with the purpose of acquiring production experience, professional self-realization and increasing the competitiveness of future specialists
Effects of control interventions on Clostridium difficile infection in England: an observational study
Background: The control of Clostridium difficile infections is an international clinical challenge. The incidence of C difficile in England declined by roughly 80% after 2006, following the implementation of national control policies; we tested two hypotheses to investigate their role in this decline. First, if C difficile infection declines in England were driven by reductions in use of particular antibiotics, then incidence of C difficile infections caused by resistant isolates should decline faster than that caused by susceptible isolates across multiple genotypes. Second, if C difficile infection declines were driven by improvements in hospital infection control, then transmitted (secondary) cases should decline regardless of susceptibility. Methods: Regional (Oxfordshire and Leeds, UK) and national data for the incidence of C difficile infections and antimicrobial prescribing data (1998β2014) were combined with whole genome sequences from 4045 national and international C difficile isolates. Genotype (multilocus sequence type) and fluoroquinolone susceptibility were determined from whole genome sequences. The incidence of C difficile infections caused by fluoroquinolone-resistant and fluoroquinolone-susceptible isolates was estimated with negative-binomial regression, overall and per genotype. Selection and transmission were investigated with phylogenetic analyses. Findings: National fluoroquinolone and cephalosporin prescribing correlated highly with incidence of C difficile infections (cross-correlations >0Β·88), by contrast with total antibiotic prescribing (cross-correlations 0Β·2). Interpretation: Restricting fluoroquinolone prescribing appears to explain the decline in incidence of C difficile infections, above other measures, in Oxfordshire and Leeds, England. Antimicrobial stewardship should be a central component of C difficile infection control programmes
Spondylarthropathies (including psoriatic arthritis): 244. Validity of Colour Doppler and Spectral Doppler Ultrasound of Sacroilicac Joints Againts Physical Examination as Gold Standard
Background: Sacroiliac joints (SJ) involvement is a distinctive and charasteristic feature of Spondyloarthritis (SpA) and x-ray is the test routinely used to make a diagnosis. However, x-ray reveals late structural damage but cannot detect active inflammation. The objective of this study was to assess the validity of Doppler ultrasound in SJ. Methods: Prospective blinded and controlled study of SJ, in which three populations were compared. We studied 106 consecutive cases, who were divided into three groups: a) 53 patients diagnosed with SpA who had inflammatory lumbar and gluteal pain assessed by a rheumatologist; b) 26 patients diagnosed with SpA who didn't have SJ tenderness and had normal physical examination; c) control group of 27 subjects (healthy subjetcs or with mechanical lumbar pain). All patients included that were diagnosed with SpA met almost the European Spondyloarthropathy Study Group (ESSG) classification criteria. Physical examination of the SJ included: sacral sulcus tenderness, iliac gapping, iliac compression, midline sacral thrust test, Gaenslen's test, and Patrick s test were used as gold standard. Both SJ were examined with Doppler ultrasound (General Electric Logiq 9, Wauwatosa WI, USA) fitted with a 9-14 Mhz lineal probe. The ultrasonographer was blinded to clinical data. Doppler in SJ was assessed as positive when both Doppler colour and resistance index (RI)β<β0.75 within the SJ area were present. Statistical analysis was performed estimating sensitivity and specificity against gold standard. The Kappa correlation coefficient was used for reliability study. Results: 106 cases (53 female, 55 male; mean age 36 10 years) were studied. There were no statistical differences between groups related to age or sex. Physical examination of SJ was positive in 38 patients (59 sacroiliac joints). US detected Doppler signal within SJ in 37 patients (58 SJ): 33 of them were symptomatic SpA (52 SJ), one of them were asymptomatic SpA (1 SJ) and one was a healthy control (1 SJ). The accuracy of US when compared to clinical data as gold standard at subject level in the overall group was: sensitivity of 68.6% and specificity of 85.7%, positive predictive value of 70.5% and negative predictive value of 84.5%. A positive likelihood ratio of 4.8, a negative likelihood ratio of 0.36 and a kappa coefficient of 0.55 were achieved. Conclusions: Doppler US of SJ seems to be a valid method to detect active SJ inflammation. Disclosure statement: The authors have declared no conflicts of interes
Genetic Determinant of Intrinsic Quinolone Resistance in Fusobacterium canifelinum
Fourteen fluoroquinolone-resistant fusobacterial strains, originating from cats or dogs, were characterized by sequencing of the 16S-23S and 16S rRNA genes and DNA-DNA hybridization and were described as a new species, Fusobacterium canifelinum. All of the strains are intrinsically resistant (MIC, >4 g/ml) to levofloxacin and other fluoroquinolones. Compared to the quinolone resistance-determining region (gyrA) of the susceptible relative F. nucleatum, we found that Ser79 was replaced with leucine and Gly83 was replaced with arginine
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