Constructive Multiuser Interference in Symbol Level Precoding for the MISO Downlink Channel

This paper investigates the problem of interference among the simultaneous multiuser transmissions in the downlink of multiple antennas systems. Using symbol level precoding, a new approach towards the multiuser interference is discussed along this paper. The concept of exploiting the interference between the spatial multiuser transmissions by jointly utilizing the data information (DI) and channel state information (CSI), in order to design symbol-level precoders, is proposed. In this direction, the interference among the data streams is transformed under certain conditions to useful signal that can improve the signal to interference noise ratio (SINR) of the downlink transmissions. We propose a maximum ratio transmission (MRT) based algorithm that jointly exploits DI and CSI to glean the benefits from constructive multiuser interference. Subsequently, a relation between the constructive interference downlink transmission and physical layer multicasting is established. In this context, novel constructive interference precoding techniques that tackle the transmit power minimization (min power) with individual SINR constraints at each user's receivers is proposed. Furthermore, fairness through maximizing the weighted minimum SINR (max min SINR) of the users is addressed by finding the link between the min power and max min SINR problems. Moreover, heuristic precoding techniques are proposed to tackle the weighted sum rate problem. Finally, extensive numerical results show that the proposed schemes outperform other state of the art techniques.Comment: Submitted to IEEE Transactions on Signal Processin

Symbol Based Precoding in The Downlink of Cognitive MISO Channels

This paper proposes symbol level precoding in the downlink of a MISO cognitive system. The new scheme tries to jointly utilize the data and channel information to design a precoding that minimizes the transmit power at a cognitive base station (CBS); without violating the interference temperature constraint imposed by the primary system. In this framework, the data information is handled at symbol level which enables the characterization the intra-user interference among the cognitive users as an additional source of useful energy that should be exploited. A relation between the constructive multiuser transmissions and physical-layer multicast system is established. Extensive simulations are performed to validate the proposed technique and compare it with conventional techniques.Comment: CROWNCOM 201

Alveolar Macrophage Interaction With Air Pollution Particulates

We applied flow cytometric analysis to characterize the in vitro response of alveolar macrophages (AM) to air pollution particulates. Normal hamster AM were incubated with varying concentrations of residual oil fly ash (ROFA) or concentrated ambient air particulates (CAP). We found a dose-dependent increase in AM-associated right angle light scatter (RAS) after uptake of ROFA (e.g., mean channel number 149.4 ± 6.5, 102.5 ± 4.1, 75.8 ± 3.5, and 61.0 ± 4.6 at 200, 100, 50, and 25 mg/ml, respectively) or CAP. A role for scavenger-type receptors (SR) in AM uptake of components of ROFA and CAP was identified by marked inhibition of RAS increases in AM pretreated with the specific SR inhibitor polyinosinic acid. We combined measurement of particle uptake (RAS) with flow cytometric analysis of intracellular oxidation of dichlorofluorescin. Both ROFA and CAP caused a dose-related intracellular oxidant stress within AM, comparable to that seen with phorbol myristate acetate (PMA) (e.g., fold increase over control, 6.6 ± 0.4, 3.6 ± 0.4, 4.6 ± 0.5, 200 mg/ml ROFA, 100 mg/ml ROFA, and $10^{-7}$ M PMA, respectively). We conclude that flow cytometry of RAS increases provides a useful relative measurement of AM uptake of complex particulates within ROFA and CAP. Both ROFA and CAP cause substantial intracellular oxidant stress within AM, which may contribute to subsequent cell activation and production of proinflammatory mediators

Heterogeneity in susceptibility dictates the order of epidemiological models

The fundamental models of epidemiology describe the progression of an infectious disease through a population using compartmentalized differential equations, but do not incorporate population-level heterogeneity in infection susceptibility. We show that variation strongly influences the rate of infection, while the infection process simultaneously sculpts the susceptibility distribution. These joint dynamics influence the force of infection and are, in turn, influenced by the shape of the initial variability. Intriguingly, we find that certain susceptibility distributions (the exponential and the gamma) are unchanged through the course of the outbreak, and lead naturally to power-law behavior in the force of infection; other distributions often tend towards these "eigen-distributions" through the process of contagion. The power-law behavior fundamentally alters predictions of the long-term infection rate, and suggests that first-order epidemic models that are parameterized in the exponential-like phase may systematically and significantly over-estimate the final severity of the outbreak

High-Molecular-Weight Human Epidermal Transglutaminase

Human stratum corneum was extracted in Tris-HCl containing EDTA and phenylmethylsulfonyl fluoride, separated on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, transblotted to nitrocellulose papers and reacted with rabbit antihuman epidermal transglutaminase (ETG) antibody. Protein-bound antibody was detected with a multistep peroxidase procedure. Proteins with a molecular weight of 50,000 (50kDa) and 72,000 daltons (72kDa) were stained when anti-ETG Was used and not when second antibody alone or sera from nonimmunized animals were used. When ETG was treated with trypsin or organic solvents, there was no alteration in the mobility of the 50kDa ETC band, but there was complete disappearance of the 72kDa band. Antibody that bound 72kDa protein, when eluted from the blot, reacted with both 50kDa and 72kDa proteins; similarly, antibody that bound to the 50kDa protein, when eluted from the blot, reacted with both the 50kDa and 72kDa proteins. Partially purified 72kDa ETG activity was increased (3 to 16 times control levels) after heating at 56°C in the presence of calcium and dithiothreitol or by treatment with trypsin. These studies, in conjunction with the previous studies of ETG activation, are consistent with there being two forms of ETG. The different forms may play a role in regulating enzyme activity

A Direct Measurement of the Total Gas Column Density in Orion KL

The large number of high-J lines of C^(18)O available via the Herschel Space Observatory provide an unprecedented ability to model the total CO column density in hot cores. Using the emission from all the observed lines (up to J = 15-14), we sum the column densities in each individual level to obtain the total column after correcting for the population in the unobserved states. With additional knowledge of source size, V_(LSR), and line width, and both local thermodynamic equilibrium (LTE) and non-LTE modeling, we have determined the total C^(18)O column densities in the Extended Ridge, Outflow/Plateau, Compact Ridge, and Hot Core components of Orion KL to be 1.4 × 10^(16) cm^(–2), 3.5 × 10^(16) cm^(–2), 2.2 × 10^(16) cm^(–2), and 6.2 × 10^(16) cm^(–2), respectively. We also find that the C^(18)O/C^(17)O abundance ratio varies from 1.7 in the Outflow/Plateau, 2.3 in the Extended Ridge, 3.0 in the Hot Core, and to 4.1 in the Compact Ridge. This is in agreement with models in which regions with higher ultraviolet radiation fields selectively dissociate C^(17)O, although care must be taken when interpreting these numbers due to the size of the uncertainties in the C^(18)O/C^(17)O abundance ratio