Regioselective and facile oxidative thiocyanation of anilines and indoles with trans-3,5?dihydroperoxy-3,5?dimethyl?1,2?dioxolane

Oxidative potential of trans3,5dihydroperoxy3,5dimethyl1,2dioxolane (DHPODMDO) has been explored in the facile thiocyanation of anilines and indoles through the efficient and in situ generation of SCN+ ion from sodium thiocyanate. The reactions proceed with regioselectivity under mild conditions at room temperature to afford the respective thiocyanate derivatives in excellent yields and low reaction times

Removal of styrene by the synthesized ZnO nanoparticles coated on the activated carbon adsorbent in the presence of UV irradiation

Background: Volatile organic compounds are the major environmental pollutants causing adverse effects on the human health and the environment, therefore, tremendous effort has been put toward eliminating these compounds. Methods: In this study, the effect of synthesized nanoparticles on the removal of styrene from gas phase by photocatalytic process under UV irradiation in the cylindrical photoreactor was studied. The activated carbon-zinc oxide (AC-ZnO) catalysts were prepared at different weight ratios (6%, 12%, and 18%) of ZnO. The prepared catalyst was characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and Brunauer-Emmett-Teller (BET) analyses. The effects of various parameters, such as concentrations of styrene, various weight percentage (wt%) of nanoparticles, and UV irradiation, were investigated. The efficiency of the AC-ZnO catalyst was determined based on its adsorption capacity, breakthrough time, and removal efficiency. Results: It was revealed that the photocatalytic removal efficiency of styrene was high in the presence of both ZnO nanoparticle and AC under UV light. Under optimal conditions, the efficiency of UV/ACZnO 18%, UV/AC-ZnO 12%, and UV/AC-ZnO 6% catalysts was 77%, 86%, and 83%, respectively. By increasing the concentration of input styrene, the photocatalytic removal efficiency was reduced, while the adsorption capacity of styrene increased. Conclusion: According to the results, the AC-ZnO 12% exhibited higher activity compared to other photocatalysts. Also, the amount of stabilized ZnO nanoparticles on the activated carbon affects the elimination rate of styrene. Keywords: Photocatalysis, Activated carbon, Styrene, Zinc oxid

Rationally Designed Ruthenium Complexes for Breast Cancer Therapy

Since the discovery of the anticancer potential of ruthenium-based complexes, several species were reported as promising candidates for the treatment of breast cancer, which accounts for the greatest number of new cases in women every year worldwide. Among these ruthenium complexes, species containing bioactive ligand(s) have attracted increasing attention due to their potential multitargeting properties, leading to anticancer drug candidates with a broader range of cellular targets/modes of action. This review of the literature aims at providing an overview of the rationally designed ruthenium-based complexes that have been reported to date for which ligands were carefully selected for the treatment of hormone receptor positive breast cancers (estrogen receptor (ER+) or progesterone receptor (PR+)). In addition, this brief survey highlights some of the most successful examples of ruthenium complexes reported for the treatment of triple negative breast cancer (TNBC), a highly aggressive type of cancer, regardless of if their ligands are known to have the ability to achieve a specific biological function

The nature of Guarantee from the Perspective of Emamieh Jurisprudence

With regard to the progress and expansion of human society real and legal individuals in order to adjust the supply of financial and commercial relations through new ways to provide guaranty with respect to the nature of transference transaction of so called in the works of Emamieh  Jurisprudence. Due to some business rules and the apparent lack of coordination. Between the nature of annexation and transference transaction in addition to the mentioned facts this article deals with examining the history and activities about guarantee in the works of Shi'i jurisprudence offering votes of the scholars of Shi'i jurisprudence plus analysis and criticism of the reasons of views based on works of Shi'i jurisprudence concluded that legality of annexation nature of guarantee which provides commitment and engagement in transaction

Selective and facile oxidative desulfurization of thioureas and thiobarbituric acids with singlet molecular oxygen generated from <i>trans-</i>3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane

<div><p>ABSTRACT</p><p>An efficient and facile procedure using <i>trans</i>-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane has been developed for oxidative desulfurization of thioureas and thiobarbituric acids. The reactions proceeded smoothly very fast under mild conditions in basic media at room temperature to afford the respective ureas in excellent yields. Simple procedure and work up, mild conditions, high yields, short reaction times, use of highly potent and non-toxic oxidant are the main merits of the present method.</p></div

Anticancer Activity and Catalytic Potential of Ruthenium(II)–Arene Complexes with N,O-Donor Ligands

International audienceThe special ability of organometallic complexes to catalyze various transformations might offer new effective mechanisms for the treatment of cancer. Studies that report both the biological properties and the ability of metallic complexes to promote therapeutically relevant catalytic reactions are limited. Herein, we report the anticancer activity and catalytic potential of some ruthenium(II)-arene complexes bearing bidentate Schiff base ligands (2a and 2b) and their reduced analogues (5a and 5b, respectively). In comparison to their Schiff base counterparts 2a and 2b, we demonstrate that amine complexes 5a and 5b display (i) a higher in vitro antiproliferative activity on different human cancer cell lines, (ii) a lower rate of hydrolysis, and (iii) an improved initial catalytic rate for the reduction of NAD+ to NADH. In contrast to their imine analogues 2a and 2b, we also show that amine complexes 5a and 5b induce the generation of intracellular reactive oxygen species (ROS) in MCF-7 breast cancer cells. Our results highlight the impact that a simple ligand modification such as the reduction of an imine moiety can have on both the catalytic and biological activities of metal complexes. Moreover, the ruthenium complexes reported here display some antiproliferative activity against T47D breast cancer cells, known for their cis-platin resistance

Evaluation the skid trail effect on annual ring width fluctuations in Beech (Fagus orientalis Lipsky) and Alder (Alnus subcordata C. A. Mey.) trees (District Nav No. 1, Asalem forests, Guilan)

Each skid trail construction affects the trees located on the road margins in various extents. The present study was conducted with the aim to assess the changes in annual ring widths of Beech and Alder trees compared to the control trees inside the Nav District in Asalem forests. To this aim, 40 samples from previously felled Alder and Beech even-age trees were randomly drawn alongside and inside the forest stands. Disks were acquired from the trees and were perfectly polished with sanding machine. They were finally used to measure annual ring widths with an accuracy of 0.01 mm. Effect of species (Alder and Beech) and location (along the skid trail and inside of stand) on the average width of annual ring were analysed using a two-way ANOVA test in a complete randomized design. Results indicated larger average annual ring width of marginal trees (0.20mm and 0.38mm for Beech and Alder trees, respectively) compared to those located inside the stand. Moreover, ANOVA results indicated highly significant main effect of species and location on the average of annual ring width, while their interaction was shown to be insignificant.  It can be concluded that this increase of trees growth in marginal trees may compensate the loss of volume caused by skid trails construction

Lipophilicity-antiproliferative activity relationship study leads to the preparation of a ruthenium(II) arene complex with considerable in vitro cytotoxicity against cancer cells and a lower in vivo toxicity in zebrafish embryos than clinically approved cis-platin.

International audienceRu(II)-arene complexes are attracting increasing attention due to their considerable antitumoral activity. However, it is difficult to clearly establish a direct relationship between their structure and antiproliferative activity, as substantial structural changes might not only affect their anticancer activity but also tightly control their activation site(s) and/or their biological target(s). Herein, we describe the synthesis and characterization of four ruthenium(II) arene complexes bearing bidentate N,O-donor Schiff-base ligands ([Ru(η(6)-benzene)(N-O)Cl]) that display a significantly distinct antiproliferative activity against cancer cells, despite their close structural similarity. Furthermore, we suggest there is a link between their respective antiproliferative activity and their lipophilicity, as the latter affects their ability to accumulate into cancer cells. This lipophilicity-cytotoxicity relationship was exploited to design another structurally related ruthenium complex with a much higher antiproliferative activity (IC50 > 25.0 μM) against three different human cancer cell lines. Whereas this complex shows a slightly lower activity than that of clinically approved cis-platin against the same human cancer cell lines, it displays a lower toxicity in zebrafish (Danio rerio) embryos at concentrations up to 20 μM