472 research outputs found
Failure strength of thin-walled cylindrical GFRP composite shell against static internal and external pressure for various volumetric fiber fraction
A study on a Circular cylindrical thin-walled shell failure made of GRP composite subjected to static internal and external pressure was carried out. The results were acquired using analytical and FEM simulation approaches for various volumetric fiber fractions. Fiber breakage, matrix breakage, interlaminate shear deformation, delamination shear deformation and micro buckling failure were investigated employing maximum failure criteria against internal and external pressure. One-ply cylindrical shell with fiber angle orientation of 0 degree was modeled in ABAQUS finite element simulation and the result was varied using analytical approaches. Moreover, the pressure fluctuations for various volumetric fiber fraction were quadratic according to plotted graphs. Meanwhile, MATLAB software was used for theoretical analysis. The comparison of two approaches was proved to be accurate. Subsequently, failure strength of various laminated GFRP cylindrical shell with different fiber angle orientations at each ply was studied for diverse volumetric fiber fraction factors. Stacking sequence, fiber angle orientations were mainly effective on failure strength
Beneficial effects of whey protein preloads on some cardiovascular diseases risk factors of overweight and obese men are stronger than soy protein preloads - A randomized clinical trial
Background The hypothesis that long term supplemental preloads of whey protein concentrate (WPC) and soy protein isolate (SPI) 30 min before the largest meal, will improve blood pressure (BP), fasting blood sugar (FBS) and lipid profile of overweight and obese men in their in free living condition was tested. Methods Forty - five men of 52, BMI = 25-40 kg/m2, after random allocation in WPC (n = 26) or SPI (n = 19) groups, drank 65 gr WPC or 60 gr SPI dissolved in 500 ml water 30 min before their ad libitum lunch for 12 weeks. Lipid profile and FBS were assessed before and after the study. Systolic and diastolic BP were measured before and after the study and every two weeks. Results After 12 weeks, mean changes between the groups were significant for SBP (p < 0.02), DBP (p = 0.001), apo A-I, apo B (p < 0.001), LDL (p = 0.015), HDL (p = 0.017). Within group mean changes of WPC were significant for reduction of DBP, FBS, apo B, VLDL, LDL, TG (p < 0.001), SBP, TC (p = 0.001), and for increase of apo A-I (p < 0.001) and HDL (p = 0.001) relative to baseline. In SPI group, mean changes were significant relative to baseline for decrease of SBP (p < 0.02), DBP (p = 0.001), apo B (p < 0.001), LDL (p = 0.015) and for increase of apo A-I (p < 0.001) and HDL (p = 0.017). Conclusion According to this study, WPC preloads at 30 min before ad libitum main meal, exert stronger beneficial effects than SPI preloads on BP, FBS and lipid profile of free living overweight and obese men after 12 weeks. Trial registration: Iranian Registry of Clinical Trials: IRCT201109062365N3. © 2015 Published by Elsevier Inc
Association between paraoxonase-1 gene promoter T (-107) C polymorphism and coronary artery disease
Background: Paraoxonase-1(PON1), a high-density lipoprotein (HDL) associated enzyme, is believed to contribute in the pathogenesis of coronary artery disease (CAD). The aim of this study was to evaluate the association of PON1 promoter C (-107)T polymorphism with the extent of coronary artery stenosis in Iranian patients. Methods: The RFLP analysis for determination of the C(-107)T genotype distribution and measurement of serum PON1 activities (Paraoxonase and Arylesterase) were performed in 99 patients. They were undergone coronary angiography to determine the number of stenotic vessels and classified into three groups: single vessel disease (SVD), two vessels disease (2VD) and three vessels disease (3VD). Results: The C(-107)T polymorphism was significantly associated with serum arylesterase activity but not with paraoxonase activity. The CC and TT genotypes distributed inversely in SVD as compared with 3VD group. Moreover, the CC high activity genotype frequency decreased with increase of stenotic vessels in patients. Conclusion: The reduced arylesterase activity as a function from the weak promoter activity increases the stenosis severity, so that, we assume it is one of the progressive factors of atherosclerotic process in stenotic vessels
Effects of physalis alkekengi, aerial parts extracts, on morphine withdrawal syndrome in mice
The effect of Physalis alkekengi aerial part extract on the withdrawal syndrome was determined in mice. After induction of dependency by morphine, mice were intraperitoneally administered different concentrations of Physalis alkekengi extract (dichloromethane, methanol and waterf). Morphine-withdrawal, induced by naloxone, was assessed by recording the incidence of escape jumps for 60 minutes. All the concentrations of the methanol extract produced statistically significant decrease in development of morphine dependence compared to the control group. Aqueous extract also induced jumping decrease in mice of test group at doses 50, 100 and 200 mg/kg. We can therefore suggest this plant using successfully in treatment of addiction
comparison of three adjuvant chemotherapy regimes using an extended log-logistic model in women with operable breast cancer
Objective: The main objective of the present study was to compare the effects of three common chemotherapy regimes in terms of disease-free survival (DFS) of breast cancer (BC) patients; the three explored regimes were taxane-based, anthracycline-based and CMF (cyclophosphamide methotrexate and 5-fluorouracil). Materials and methods: In this historical-cohort study, we obtained the information of 62 patients with confirmed BC in non-metastatic stage and followed them for 8 years. All the patients had undergone modified radical mastectomy surgery and had received adjuvant chemotherapy in three medical centers in Tehran, Iran. DFS was considered as the end-point. Afterwards, an extended log-logistic regression model was used to compare these regimes. Results: The mean (SD) age of patients was 49.0 (10.3) years. The median time of follow-up was 20.0 months and the probability of 5-years DFS was 0.48. Survival analysis indicated that the type of chemotherapy (OR(CMF vs. taxane) = 0.33, OR(anthracycline vs. taxane) = 0.74), grade (OR(III vs. I or II) = 0.35), tumor size (OR(>5cm vs. <5cm)= 0.179) and nodal involvements (OR(Yes vs. No)= 0.36) affected DFS. Conclusion: The current study revealed that the efficacy of taxane-based, in terms of DFS, was more than CMF (p = 0.05). Moreover, taxane-based chemotherapy prolonged DFS more than anthracycline-based one although the difference was not significant (p= 0.63). Finally, considering the importance of tumor size, histological grade and number of involved lymph nodes in lengthening DFS, it is crucial to highlight the role of public education and screening programs in order to detect tumor in its early stages
The chain rule implies Tsirelson's bound: an approach from generalized mutual information
In order to analyze an information theoretical derivation of Tsirelson's
bound based on information causality, we introduce a generalized mutual
information (GMI), defined as the optimal coding rate of a channel with
classical inputs and general probabilistic outputs. In the case where the
outputs are quantum, the GMI coincides with the quantum mutual information. In
general, the GMI does not necessarily satisfy the chain rule. We prove that
Tsirelson's bound can be derived by imposing the chain rule on the GMI. We
formulate a principle, which we call the no-supersignalling condition, which
states that the assistance of nonlocal correlations does not increase the
capability of classical communication. We prove that this condition is
equivalent to the no-signalling condition. As a result, we show that
Tsirelson's bound is implied by the nonpositivity of the quantitative
difference between information causality and no-supersignalling.Comment: 23 pages, 8 figures, Added Section 2 and Appendix B, result
unchanged, Added reference
- …