Outpatient-Based Therapy of Oral Fludarabine and Subcutaneous Alemtuzumab for Asian Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

Background. Intravenous alemtuzumab and fludarabine are effective in combination for the treatment of chronic lymphocytic leukemia (CLL), but require hospital visits for intravenous injection. We performed a pilot study to assess the safety and efficacy of outpatient-based oral fludarabine with subcutaneous alemtuzumab (OFSA) for the treatment of relapsed/refractory CLL. Results. Depending on their response, patients were given two to six 28-day cycles of subcutaneous alemtuzumab 30 mg on days 1,3, and 5 and oral fludarabine 40 mg/m2/day for 5 days. Median patient age was 74. The lymphocyte counts of all five patients fell after the 1st cycle of treatment and reached normal/low levels on completion of 2 to 6 cycles of therapy. Platelet counts and hemoglobin were unaffected. All five patients achieved complete hematological remission, while two attained minimal residual disease negativity on 4-color flow cytometry. Conclusions. Our OFSA regimen was effective in elderly Asian patients with relapsed/refractory CLL, and it should be investigated further

Factors associated with nursing home placement of all patients admitted for inpatient rehabilitation in Singapore community hospitals from 1996 to 2005: A disease stratified analysis

10.1371/journal.pone.0082697PLoS ONE812-POLN

Purification and characterization of recombinant malate synthase enzymes from streptomyces coelicolor a3(2) and s. clavuligerus Nrrl3585

10.1038/sj.jim.7000240Journal of Industrial Microbiology and Biotechnology284239-243JIMB

Muscle coordination during single-leg landing: Implications for ACL injuries

F1 - Full Written Papers Referee

Post-radioembolization yttrium-90 PET/CT-part 1: Diagnostic reporting

10.1186/2191-219X-3-56EJNMMI Research311-2

A Case-Based Approach for Modelling the Risk of Driver Fatigue

Part 2: Cognitive ComputingInternational audienceFatigue-related crashes are one of the major threats to road safety worldwide. Despite the substantial work in the domain of transportation science by both the industry and academia, there are few studies in applying case-based reasoning (CBR) approach to modelling the risk of driver fatigue. This research explores the potential for fatigued driving using a database of 16,459 traffic crashes reported from 21 cities in Guangdong province, China from 2006 to 2010. The CBR system under development differentiates between fatigued-driving and non-fatigued-driving cases based on various personal and environmental traffic characteristics. The advantage of using CBR in modelling fatigued driving has been demonstrated through empirical evaluation