Surgeon’s perspective on rare yet potentially fatal complication of GI perforation following endoscopy

Gastrointestinal endoscopy plays an essential role in the diagnosis, staging, and treatment of pathologies of the GI tract. New-generation endoscopes, advanced imaging technologies, the introduction of new therapeutic devices into clinical practice, and modification of old techniques have expanded both the diagnostic and therapeutic armamentarium of the endoscopist. complications are rare with a rate of less than 1 per 5000 cases. perforations are either due to therapeutic dilatation,  coagulation or passage of side viewing instrument  into the duodenum. Here we present a case of 56 yr old male who underwent diagnostic endoscopy for peptic ulcer. I t lead to endoscope induced large duodenal perforation of about 10 cms in its long axis recognized at laparotomy 10 days after the intervention.it is important to mention the perforation was repaired surgically and patient developed no post operative complications. Undesired complications though rare, are potentially fatal and risks need to be evaluated before performing all endoscopic procedure

Safety Analysis of a Multispecialty Surgical Volunteerism Mission Over Thirteen Years - Age Alone is not a Contradiction

INTRODUCTION: About five billion people worldwide lack access to safe surgery and multispecialty surgical volunteer missions (SVMs) offer a plausible solution to this problem. This study aimed to evaluate the outcomes of elderly patients operated on over 13 surgical missions between 2006 and 2019 from Operation Giving Back Bohol Tagbilaran, Philippines. PATIENTS AND METHODS: This was a retrospective analysis of prospectively collected data on all patients treated during SVM over 13 years (2006-2019). Non-elderly (age 16-64 years) were compared with the elderly (age ≥65 years) for pre-, intra-, and postoperative variables. Multivariable logistic regression was utilized to identify independent predictors of postoperative complications. RESULTS: Of 1184 patients, the majority (1030) were in the non-elderly group and 154 in the elderly. The mean age was 36 ± 13.6 and 68.3 ± 3.8 years in the non-elderly and elderly groups, respectively. Comorbidities, type of surgery, type of anesthesia, operating time, estimated blood loss, estimated blood loss, need for blood transfusion, postoperative complication rates, comprehensive complication index, length of hospital, ICU requirement, and mortality rates stay did not significantly differ between the groups. Multivariable logistic regression found pelvic surgery (OR (95%CI) = 3.7 (1.3-10.8); CONCLUSIONS: Elderly patients may be safely undergo general surgery procedures in surgical volunteer missions, and age alone should not preclude them

Jejunal Diverticular Perforation Causing Small Bowel Obstruction in a Type 4 Hiatal Hernia: A Rare Case Report of a Nonagenarian Patient and Review of Relevant Literature

Type IV paraesophageal hernia (PEH) is very rare and is characterized by the intrathoracic herniation of the abdominal viscera other than the stomach into the chest. We describe a case of a 90-year-old male patient who presented at our emergency department complaining of epigastric pain that he had experienced over the past few hours and getting progressively worse. On the day after admission, his pain became severe. Chest radiography revealed an intrathoracic intestinal gas bubble; emergency exploratory laparotomy identified a type IV PEH with herniation of only the jejunum with perforated diverticula on mesenteric side through a hiatal defect into mediastinum. There are a few published cases of small bowel herniation into the thoracic cavity in the literature. Our patient represents a rare case of an individual diagnosed with type IV PEH with herniation of jejunum with perforated diverticula

Does Endovascular Repair for Blunt Traumatic Aortic Injuries Provide Better Outcomes Compared to Its Open Technique? A Systematic Review and Meta-analysis

INTRODUCTION: Traumatic aortic injuries are devastating events in terms of high mortality and morbidity in most survivors. We aimed to compare the outcomes of endovascular repair (ER) vs. open repair (OR) in the treatment of traumatic aortic injuries. METHODS: PubMed, Embase, and Cochrane Library were systematically searched. Postoperative mortality was the primary endpoint. Secondary endpoints included intensive care unit (ICU) length of stay, hospital length of stay, operating time, paraplegia, stroke, acute renal failure, and reoperation rate. The Mantel-Haenszel method (random-effects model) with odds ratios and 95% confidence intervals (OR (95% CI)), and the inverse variance method with the mean difference (MD (95% CI)), were used to measure the effects of continuous and categorical variables, respectively. RESULTS: A total of 49 studies involving 12,857 patients were included. Postoperative mortality was not significantly different between the two groups (p=0.459). Among secondary outcomes, the paraplegia rate was significantly lower after ER (p=0.032). Other secondary endpoints such as ICU length of stay (p=0.329), hospital length of stay (p=0.192), operating time (p=0.973), stroke rate (p=0.121), ARF rate (p=0.928), and reoperation rate (p=0.643) did not significantly differ between the two groups. CONCLUSION: This meta-analysis found that ER was associated with a reduced paraplegia rate compared to OR for the management of traumatic aortic injury

Does computed tomography scan add any diagnostic value to the evaluation of stab wounds of the anterior abdominal wall? A systematic review and meta-analysis

BACKGROUND: The aim of this systematic review and meta-analysis was to evaluate whether computed tomography (CT) scan adds any diagnostic value in the evaluation of stab wounds of the anterior abdominal wall as compared with serial clinical examination (SCE). METHODS: PubMed, EMBASE, Cochrane Library, and MEDLINE via Ovid were systematically searched for records published from 1980 to 2018 by two independent researchers (M.G., R.L.). Quality assessment, data extraction, and analysis were performed according to the Cochrane Handbook for Systematic Reviews of Interventions. Mantel-Haenszel method with odds ratio (OR) and 95% confidence interval (95% CI) as the measure of effect size was used for meta-analysis. RESULTS: Three studies (1 randomized controlled trial and 2 observational studies) totaling 319 patients were included in the meta-analysis. Overall laparotomy rate was 12.8% (22 of 172 patients) in SCE versus 19% (28 of 147 patients) in CT. This difference was not significant (OR [95% CI], 0.63 [0.34-1.16]; p = 0.14). Negative laparotomy rate was 3.5% (6 of 172 patients) in SCE versus 5.4% (8 of 147 patients) in CT. The difference was not significant (OR [95% CI], 0.61 [0.20-1.83]; p = 0.37). CONCLUSION: This meta-analysis compared SCE with CT scan in patients presenting with stab wounds of the anterior abdominal wall and provided level II evidence showing no additional benefit in CT scan. Further observational and experimental clinical studies are needed to confirm the findings of this meta-analysis. LEVEL OF EVIDENCE: Systematic review and meta-analysis, level II

Thyroidectomy in a Surgical Volunteerism Mission: Analysis of 464 Consecutive Cases

Although surgical volunteer missions (SVMs) have become a popular approach for reducing the burden of surgical disease worldwide, the outcomes of specific procedures in the context of a mission are underreported. The aim of this study was to evaluate outcomes and efficiency of thyroid surgery within a surgical mission. This was a retrospective analysis of medical records of all patients who underwent thyroid surgery within a SVM from 2006 to 2019. Postoperative complication rate was the safety endpoint, whereas length of hospital stay (LOS) was the efficiency endpoint. Serious complications were defined as Clavien-Dindo class 3-5 complications. Expected safety and efficiency outcomes were calculated using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) surgical risk calculator and compared to their observed counterparts. A total of 464 thyroidectomies were performed during the study period. Mean age of the patients was 40.3 +/- 10.8 years, and male-to-female ratio was 72 : 392. Expected overall (p=0.127) and serious complication rates (p=0.738) were not significantly different from their observed counterparts. Expected LOS was found to be significantly shorter as compared to its observed counterpart (0.6 +/- 0.2 vs. 2.5 +/- 1.0 days; p \u3c 0.001). This study found thyroid surgery performed within a surgical mission to be safe. NSQIP surgical risk calculator underestimates the LOS following thyroidectomy in surgical missions

Does Computed Tomography Scan Add Any Diagnostic Value to the Evaluation of Stab Wounds of the Anterior Abdominal Wall? A Systematic Review and Meta-Analysis

BACKGROUND: The aim of this systematic review and meta-analysis was to evaluate whether computed tomography (CT) scan adds any diagnostic value in the evaluation of stab wounds of the anterior abdominal wall as compared with serial clinical examination (SCE). METHODS: PubMed, EMBASE, Cochrane Library, and MEDLINE via Ovid were systematically searched for records published from 1980 to 2018 by two independent researchers (M.G., R.L.). Quality assessment, data extraction, and analysis were performed according to the Cochrane Handbook for Systematic Reviews of Interventions. Mantel-Haenszel method with odds ratio (OR) and 95% confidence interval (95% CI) as the measure of effect size was used for meta-analysis. RESULTS: Three studies (1 randomized controlled trial and 2 observational studies) totaling 319 patients were included in the meta-analysis. Overall laparotomy rate was 12.8% (22 of 172 patients) in SCE versus 19% (28 of 147 patients) in CT. This difference was not significant (OR [95% CI], 0.63 [0.34-1.16]; p = 0.14). Negative laparotomy rate was 3.5% (6 of 172 patients) in SCE versus 5.4% (8 of 147 patients) in CT. The difference was not significant (OR [95% CI], 0.61 [0.20-1.83]; p = 0.37). CONCLUSION: This meta-analysis compared SCE with CT scan in patients presenting with stab wounds of the anterior abdominal wall and provided level II evidence showing no additional benefit in CT scan. Further observational and experimental clinical studies are needed to confirm the findings of this meta-analysis. LEVEL OF EVIDENCE: Systematic review and meta-analysis, level II

Venous Thromboembolism in Geriatric Trauma Patients-Risk Factors and Associated Outcomes

BACKGROUND: Venous thromboembolism (VTE) places elderly trauma patients at a high risk of morbidity. The purpose of this study was to determine the outcomes related to VTE in geriatric trauma patients, as well as to identify risk factors for the development of VTE in this population. We also assessed the impact of the type and timing of VTE prophylaxis, and the type of injuries, on development of VTE in geriatric trauma population. METHODS: We performed a 2-year retrospective review from American College of Surgeons-Trauma Quality Improvement Project (ACS-TQIP) databank from 2014 to 2016. A total of 354,272 patients aged 65 y or older who developed VTE after trauma were included in the study. RESULTS: Overall, 354,272 elderly trauma patients with complete records were identified from the year 2014 to 2016, and of this, 4290 (1.1%) patients developed in-hospital VTE. Male gender was more predominant in the VTE group (P \u3c 0.001). Both the ICU length of stay and hospital length of stay (P \u3c 0.001) were higher in the VTE group. Spine injury (P = 0.002), lower extremity injury (P \u3c 0.001), age category 75-84 y (P \u3c 0.001), age ≥85 y (P \u3c 0.001), frailty (P \u3c 0.001), severe traumatic brain injury (TBI) (GCS3-8) (P \u3c 0.001), ventilator days (P \u3c 0.001), and transfusion of plasma products in first 24 h of admission (P \u3c 0.001) were independent predictors of developing VTE after trauma in the elderly. Higher injury severity score, TBI, and transfusion of packed red blood cells within 24 h were associated with longer time to initiate VTE prophylaxis. Time to initiate chemical deep vein thrombosis prophylaxis was significantly longer in those patients that developed VTE (3.73 ± 4.82 d), when compared with those patients without VTE ((1.81 ± 2.53 d) (P \u3c 0.001). CONCLUSIONS: Our study demonstrates that ICU and hospital length of stay were higher in VTE group. Frailty, severe TBI, spine injury, lower extremity injury, longer duration of mechanical ventilation, and transfusion of plasma products in the first 24 h of hospital admission were independent predictors of developing VTE after trauma in elderly. Type and timing of VTE prophylaxis were not significant independent predictors of developing VTE after trauma, while higher injury severity score, TBI, and transfusion of packed red blood cells within 24 h were associated with longer time to initiate VTE prophylaxis. Future multi-institutional prospective studies are warranted to gather more evidence on this topic

Passive Drainage to Gravity and Closed-Suction Drainage Following Pancreatoduodenectomy Lead to Similar Grade B and C Postoperative Pancreatic Fistula Rates. A Meta-Analysis

INTRODUCTION: There is no level 1a evidence regarding the impact of passive drainage to gravity (PDG) and closed-suction drainage (CSD) following pancreatoduodenectomy on clinical outcomes. The aim of this meta-analysis was to evaluate the impact of PDG versus CSD on surgical outcomes following pancreaticoduodenectomy in high risk patients who would benefit from pancreatic drainage. METHODS: The Pubmed, EMBASE, and Cochrane Library were systematically searched. Postoperative pancreatic fistula (POPF) rate was the primary endpoint. A subgroup meta-analysis of randomized controlled trials (RCT) was performed in addition to a meta-analysis of all eligible studies. Mantel-Haenszel method (random-effects model) with odds ratios and 95% confidence intervals (OR (95%CI)) as an effect measure was utilized. RESULTS: Six studies, whereof 3 RCTs, involving 1519 patients (806 PDG and 713 CSD) were included. In meta-analysis of all studies, overall [OR (95%CI)=0.81 (0.42, 1.56); p=0.53; I(2)=79%; Tau(2)=0.54]; grade A [OR (95%CI)=0.71 (0.33, 1.53); p=0.39; I(2)=65%; Tau(2)=0.47]; grade B [OR (95%CI)=1.23 (0.74, 2.05); p=0.42; I(2)=0%]; and grade C [OR (95%CI)=1.08 (0.56, 2.09); p=0.82; I(2)=5%] POPF rates did not differ. Subgroup analysis of RCTs confirmed the finding that grade B and C POPF rates did not significantly differ with low heterogeneity [OR (95%CI)=1.55 (0.79, 3.04); p=0.20; I(2)=0%]. No publication bias was found (t=0.48; p=0.64). CONCLUSION: This meta-analysis found no difference in short-term clinical outcomes including, clinically relevant, grade B and C POPF rates between PDG and CSD. Furthermore, postoperative complication rates were similar with the use of either drain