Expanding Full-Service Community Schools into Rural Minnesota

Communities throughout rural Minnesota would greatly benefit from full-service community schools to support academic achievement and contribute to thriving communities. Lack of health and human services, mental health disparities, and cultural divides are among the greatest concerns for students in rural areas. One in 5 children birth to eighteen has a diagnosable mental health condition and 1 out of every 10 children experience a mental health problem that is severe enough to impair how they function at home, in school, and in their communities. When youth come to school hungry or experiencing in-home trauma, academic success is hard to achieve. Many children who have mental health needs and are referred to services do not attend the first appointment. Up to three-quarters of youth end services prematurely. The full-service community school model is an approach demonstrated to increase enrollment, and improve attendance and academic outcomes. Full-service community schools around the nation are providing supports, uniting communities, reducing barriers, improving educational achieve, and reducing educational gaps. It is vital that local health and human service agencies work together with community schools to improve service delivery for students and their families. Minnesota needs to increase its investment in the full-service community school model by expanding the availability of full-service community schools throughout every region of greater Minnesota

Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

Chronic Lymphocytic Leukemia (CLL) demonstrates variable reactivity of the B cell receptor (BCR) to antigen ligation, but constitutive pathway activation. Bruton's Tyrosine Kinase (BTK) shows constitutive activity in CLL, and is the target of irreversible inhibition by ibrutinib, an orally bioavailable kinase inhibitor that has shown outstanding activity in CLL. Early clinical results in CLL with other reversible and irreversible BTK inhibitors have been less promising, however, raising the question of whether BTK kinase activity is an important target of ibrutinib and also in CLL. To determine the role of BTK in CLL, we utilized patient samples and the E\u3bc-TCL1 (TCL1) transgenic mouse model of CLL which results in spontaneous leukemia development. Inhibition of BTK in primary human CLL cells by siRNA promotes apoptosis. Inhibition of BTK kinase activity through either targeted genetic inactivation or ibrutinib in the TCL1 mouse significantly delays the development of CLL, demonstrating that BTK is a critical kinase for CLL development and expansion and thus an important target of ibrutinib. Collectively, our data confirm the importance of kinase-functional BTK in CLL