Preoperative Kidney Function linked to mortality and readmission outcomes at Day 90 and 30 in Older Emergency Surgical Patients

Grants were received from British Geriatric Society and The Renal Association to support Louis EvansPeer reviewedPublisher PD

Thoracic Outlet decompression Surgery for Gilliatt-Sumner Hand as presentation of neurogenic thoracic outlet syndrome

INTRODUCTION: Chronic compression of the inferior trunk of the brachial plexus can result in severe pain and progressive atrophy and weakness of the musculature of the forearm and hand, known as Gilliatt-Sumner Hand (GSH). The objective of treatment in these patients is to stop further atrophy and pain. Restoration of motor function is thought to be seldom achieved. The aim of this contemporary case series is to describe diagnosis, treatment and outcomes of surgery in GSH. METHODS: All patients referred between January 2017 and May 2021 with visible signs of a GSH were included. Visible GSH signs were defined as muscle atrophy of the abductor digiti minimi (ADM), abductor pollicis brevis (APB), and/or interosseous musculature. Additional electrodiagnostic assessment (EDx) and high-resolution ultrasound (HRUS) were performed in all patients. All diagnosed GSH patients underwent thoracic outlet decompression (TOD) surgery by transaxillary (TA) or supraclavicular (SC) approach. Outcomes were measured with the TOS disability scale, Cervical Brachial Score Questionnaire (CBSQ), Disability of the Arm, Shoulder, and Hand (DASH) score and patient reported outcome of motor function, measured with a numerated rating scale score (NRS). The standardized Elevated Arm Stress Test (sEAST) was used to assess motor function before and after TOD. RESULTS: Twenty patients were referred to our center with visible signs of a GSH. Clinical examination showed atrophy of the ADM, APB and interosseous musculature in all patients. EDx showed plexopathy of the lower brachial plexus in all patients. HRUS showed an indented inferior trunc of the brachial plexus (so called "wedge sickle sign" WSS) in 18 (90%) patients. Surgical treatment was performed in 17 patients (15 TA-TOD, 2 SC TOD). Three patients refrained from surgical treatment. The median follow-up interval was 15.0 (IQR 14.0) months. The TOS disability scale improved significant (Preoperative: mean 6.31, CI [5.49 - 7.13]; postoperative: mean 4.25, CI [2.80 - 5.70], p=0.026). The same was seen for the CBSQ scores (preoperative mean 77.75, CI [66.63 - 88.87]; postoperative mean 42.65, CI [24.77 - 60.77], p= 0.001) and DASH scores (preoperative mean 59.13, CI [51.49 - 66.77]; postoperative mean 40.96, CI [24.41 - 57.51]; p= 0.032. The NRS for muscle weakness and sEAST showed no statistical difference before and after TOD comparing the whole group (NRS muscle weakness preoperative mean: 6.22, CI [4.31 - 8.14]; postoperative mean: 5.11, CI [3.25 - 6.97]; p= 0.269). However, 4 (23.52%) patients had a 50% or more decrease in NRS for muscle weakness and a minimum increase of 20% in total and average force on the sEAST measurement. The NRS for numbness showed a statistically significant decrease for the whole group (preoperative mean: 5.67, CI [4.18 - 7.16]; postoperative mean: 3.33 [1.37-5.29]; p=0.029). CONCLUSION: A combination of physical examination, EDx and HRUS studies can differentiate GSH from differential diagnoses. HRUS appears has the advantage over EDx studies in confirming GSH by visualization of compression of the brachial plexus. TOD surgery will stop the progressive muscle atrophy and significantly reduce NTOS complaints and in some patients, motor function will recover

Feasibility and Outcomes of a Multidisciplinary Care Pathway for Neurogenic Thoracic Outlet Syndrome: A Prospective Observational Cohort Study

OBJECTIVE: The North American Society for Vascular Surgery (SVS) reporting standards for neurogenic thoracic outlet syndrome (NTOS) were published in 2016 to produce consistency in the diagnosis and treatment of NTOS, but outcomes resulting from following these standards are not yet available. The results of a standardised multidisciplinary care pathway for NTOS based on the North American SVS reporting standards for NTOS are reported. METHODS: Patients referred between August 2016 and December 2019 with suspected NTOS were evaluated in this single center prospective cohort study. Diagnosis and treatment were performed according to a care pathway based on the North American SVS reporting standards. The outcome of surgically treated patients was determined by the Derkash score, thoracic outlet syndrome disability scale (TDS), Cervical Brachial Score Questionnaire (CBSQ), Disability of the Arm Shoulder and Hands Dutch language version (DASH-DLV) and Short Form-12 (SF-12) at three, six, 12, and 24 months. RESULTS: Of 856 referred patients, 476 (55.6%) patients were diagnosed with NTOS. Dedicated physiotherapy was successful in 186 patients (39.1%). Surgical treatment was performed in 290 (60.9%) patients of whom 274 were included in the follow up. At a mean follow up of 16.9 ± 9.2 months, significant improvement (p < .001) in TDS, CBSQ, DASH-DLV, and SF-12 scores was seen in the surgical group between baseline and all follow up intervals. Derkash outcome after surgical intervention was excellent in 83 (30.3%), good in 114 (41.6%), fair in 43 (15.7%), and poor in 34 (12.4%) of the patients. Complications occurred in 16 (5.8%) patients, and 32 (10.4%) patients experienced recurrent or persistent NTOS complaints. CONCLUSION: A multidisciplinary care pathway based on the North American SVS reporting standards for NTOS helped to confirm the diagnosis in 56% of patients referred, and guided the selection of patients who might benefit from thoracic outlet decompression surgery after unsuccessful dedicated physiotherapy. Intermediate follow up showed good outcomes in the majority of surgically treated patients

Surgery versus continued conservative treatment for neurogenic thoracic outlet syndrome:the first randomised clinical trial (STOPNTOS-trial)

OBJECTIVES: Neurogenic Thoracic Outlet Syndrome (NTOS) is one of the most controversial clinical entities in medicine. Several major case series have shown promising results of surgery, however solid scientific evidence is lacking. The aim of this trial was to objectify the effect of thoracic outlet decompression (TOD). DESIGN: Randomised controlled clinical trial METHODS: We conducted a single center (high volume, tertiary TOS center), non-blinded, randomized controlled trial with parallel group design. Patients with a diagnosis of NTOS refractory to conservative therapy were randomized into one of two intervention arms and either received a trans-axillary thoracic outlet decompression (TA-TOD) or continued conservative treatment. After 3 months, the conservative treated group was also offered a TA-TOD. Primary outcome was the change in Disability of the Arm, Shoulder and Hand, (DASH) questionnaire score. Secondary outcomes were the change in Cervical-Brachial Symptoms Questionnaire (CBSQ), TOS disability scale and quality of life scores. Outcomes were assessed at baseline, 3, 6 and 12 months after inclusion. RESULTS: In total, 50 patients were enrolled in this trial: 25 in the TA-TOD group and 25 in the continued conservative treatment group. Follow up was completed in 24 and 22 patients respectively. At 3 months, there was a significant difference in DASH scores (TA-TOD: mean: 45.15; confidence interval (CI) [38.08 - 52.21]; conservative treatment: mean 64.92, CI [57.54 -72.30]; p<.001). All patients in the conservative treatment group applied for surgery 3 months after randomization. After surgery of the conservative treatment group, there was no significant difference between the groups for all primary and secondary outcome measures. CONCLUSIONS: TA-TOD for NTOS is effective in patients that do not respond to conservative treatment. TRIAL REGISTER NUMBER: NL63986.100.17

Duplex Ultrasound Studies Are Neither Necessary or Sufficient for the Diagnosis of Neurogenic Thoracic Outlet Syndrome

BACKGROUND: Duplex ultrasound (DU) is used in the diagnosis of neurogenic thoracic outlet syndrome (NTOS) to measure compression of the subclavian artery (SCA) which is thought to strengthen the NTOS diagnosis. However, the value of DU in NTOS remains unclear. METHODS: A retrospective review of a prospectively acquired database from the TOS center of the Catharina Hospital Eindhoven was performed of patients referred between January 2017 and December 2019. Only "proven NTOS" patients, defined as a successful response to thoracic outlet decompression (TOD) surgery based on patient-reported outcomes (NRS pain scale, CBSQ and DASH score) were included to exclude wrongfully diagnosed NTOS patient. The presence of vascular symptoms (defined as discoloration, edema or temperature changes of the hand or fingers), results of provocative maneuvers, and outcome of DU was used for analysis. To assess the link between vascular symptoms and compression on DU, a chi-squared test was performed. Further, we looked for a correlation between vascular symptoms, compression on DU and clinical outcome using a repeated measures analysis of variance (ANOVA). RESULTS: Vascular symptoms were seen in 49 of 133 patients (36.8%). In total, 51 of 133 patients (38.3%) had at least 50% variation in SCA peak systolic velocity (PSV) during DU at the level of SCA stenosis. SCA occlusion was seen in 11 patients (8.3%) during provocative maneuvers. The presence of clinical "arterial symptoms" was not significantly correlated with vascular laboratory findings, neither for alterations in PSV during DU (P = 0.245) nor for positional SCA occlusion (P = 0.540). No statistically significant correlations between the degree of SCA stenosis and postoperative outcomes, as measured with the DASH, CBSQ, or NRS scale for pain were found (P = 0.787). CONCLUSIONS: The role of DU in the work-up of NTOS in patients with vascular complaints is questionable. Changes in flow velocities are seen in NTOS patients and do not correlate with "vascular symptoms" or clinical outcome