8 research outputs found
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Acute limb ischemia from gunshot wound secondary to arterial vasospasm.
Gunshot wounds are rising in incidence, morbidity, and mortality. It is thought that about half of nonfatal injuries occur in an extremity. Although the incidence is not known, arterial vasospasm can result in acute limb ischemia. We present the case of a 33-year-old man who suffered a gunshot wound to the left lower extremity resulting in arterial vasospasm of the superficial femoral artery. He quickly regained arterial flow, and we were able to manage his acute limb ischemia nonoperatively and to document restoration of flow through serial examinations and Doppler imaging. He was subsequently discharged the next day and is experiencing a full recovery
Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation
BackgroundPerioperative cardiac xenograft dysfunction (PCXD) describes a rapidly developing loss of cardiac function after xenotransplantation. PCXD occurs despite genetic modifications to increase compatibility of the heart. We report on the incidence of PCXD using static preservation in ice slush following crystalloid or blood-based cardioplegia versus continuous cold perfusion with XVIVO© heart solution (XHS) based cardioplegia.MethodsBaboons were weight matched to genetically engineered swine heart donors. Cardioplegia volume was 30 cc/kg by donor weight, with del Nido cardioplegia and the addition of 25% by volume of donor whole blood. Continuous perfusion was performed using an XVIVO © Perfusion system with XHS to which baboon RBCs were added.ResultsPCXD was observed in 5/8 that were preserved with crystalloid cardioplegia followed by traditional cold, static storage on ice. By comparison, when blood cardioplegia was used followed by cold, static storage, PCXD occurred in 1/3 hearts and only in 1/5 hearts that were induced with XHS blood cardioplegia followed by continuous perfusion. Survival averaged 17 hours in those with traditional preservation and storage, followed by 11.47 days and 15.03 days using blood cardioplegia and XHS+continuous preservation, respectively. Traditional preservation resulted in more inotropic support and higher average peak serum lactate 14.3±1.7 mmol/L compared to blood cardioplegia 3.6±3.0 mmol/L and continuous perfusion 3.5±1.5 mmol/L.ConclusionBlood cardioplegia induction, alone or followed by XHS perfusion storage, reduced the incidence of PCXD and improved graft function and survival, relative to traditional crystalloid cardioplegia-slush storage alone
Recommended from our members
Acute limb ischemia from gunshot wound secondary to arterial vasospasm.
Gunshot wounds are rising in incidence, morbidity, and mortality. It is thought that about half of nonfatal injuries occur in an extremity. Although the incidence is not known, arterial vasospasm can result in acute limb ischemia. We present the case of a 33-year-old man who suffered a gunshot wound to the left lower extremity resulting in arterial vasospasm of the superficial femoral artery. He quickly regained arterial flow, and we were able to manage his acute limb ischemia nonoperatively and to document restoration of flow through serial examinations and Doppler imaging. He was subsequently discharged the next day and is experiencing a full recovery