962 research outputs found
Distribuição do carbono orgânico em Latossolo sob manejo da adubação fosfatada em plantio direto no Cerrado.
O objetivo deste trabalho foi avaliar a distribuição vertical e horizontal do carbono orgânico do solo (CO) sob cinco manejos da adubação fosfatada, no sistema plantio direto. O experimento foi instalado sob Latossolo Vermelho, cultivado durante oito anos com soja ou milho, com milheto como planta de cobertura na entressafra. As parcelas foram submetidas aos tratamentos: aplicação de superfosfato triplo a lanço e no sulco, fosfato natural reativo a lanço e no sulco, e ausência de adição de fertilizante fosfatado (testemunha). A adição anual dos adubos fosfatados, na dose de 80 kg ha‑1 de P2O5, foi realizada em solo inicialmente com baixo teor de fósforo disponível. Amostras foram coletadas perpendicularmente à linha de plantio, em sete pontos distanciados a 12,5 cm, e cinco camadas: 0?2,5, 2,5?5,0, 5,0?10, 10?20 e 20?30 cm. O conteúdo e a distribuição do CO são afetados pela adubação fosfatada, tanto vertical quanto horizontalmente, com os maiores conteúdos observados nos tratamentos com adubos fosfatados. Em comparação com a testemunha, o superfosfato triplo apresentou maior conteúdo de CO até a camada de 5,0?10 cm, e o fosfato natural reativo até 10?20 cm. A aplicação de fósforo em sulcos proporciona maior volume de solo com teores adequados de CO, em comparação à aplicação a lanço
Noether symmetries for two-dimensional charged particle motion
We find the Noether point symmetries for non-relativistic two-dimensional
charged particle motion. These symmetries are composed of a quasi-invariance
transformation, a time-dependent rotation and a time-dependent spatial
translation. The associated electromagnetic field satisfy a system of
first-order linear partial differential equations. This system is solved
exactly, yielding three classes of electromagnetic fields compatible with
Noether point symmetries. The corresponding Noether invariants are derived and
interpreted
On the linearization of the generalized Ermakov systems
A linearization procedure is proposed for Ermakov systems with frequency
depending on dynamic variables. The procedure applies to a wide class of
generalized Ermakov systems which are linearizable in a manner similar to that
applicable to usual Ermakov systems. The Kepler--Ermakov systems belong into
this category but others, more generic, systems are also included
Anisotropic Bose-Einstein condensates and completely integrable dynamical systems
A Gaussian ansatz for the wave function of two-dimensional harmonically
trapped anisotropic Bose-Einstein condensates is shown to lead, via a
variational procedure, to a coupled system of two second-order, nonlinear
ordinary differential equations. This dynamical system is shown to be in the
general class of Ermakov systems. Complete integrability of the resulting
Ermakov system is proven. Using the exact solution, collapse of the condensate
is analyzed in detail. Time-dependence of the trapping potential is allowed
Generalized Hamiltonian structures for Ermakov systems
We construct Poisson structures for Ermakov systems, using the Ermakov
invariant as the Hamiltonian. Two classes of Poisson structures are obtained,
one of them degenerate, in which case we derive the Casimir functions. In some
situations, the existence of Casimir functions can give rise to superintegrable
Ermakov systems. Finally, we characterize the cases where linearization of the
equations of motion is possible
Lie symmetries for two-dimensional charged particle motion
We find the Lie point symmetries for non-relativistic two-dimensional charged
particle motion. These symmetries comprise a quasi-invariance transformation, a
time-dependent rotation, a time-dependent spatial translation and a dilation.
The associated electromagnetic fields satisfy a system of first-order linear
partial differential equations. This system is solved exactly, yielding four
classes of electromagnetic fields compatible with Lie point symmetries
Effect of a Single Amino Acid Change in MHC Class I Molecules on the Rate of Progression to AIDS
Background From studies of genetic polymorphisms and the rate of progression from human immunodeficiency virus type 1 (HIV-1) infection to the acquired immunodeficiency syndrome (AIDS), it appears that the strongest susceptibility is conferred by the major-histocompatibility-complex (MHC) class I type HLA-B*35,Cw*04 allele. However, cytotoxic T-lymphocyte responses have been observed against HIV-1 epitopes presented by HLA-B*3501, the most common HLA-B*35 subtype. We examined subtypes of HLA-B*35 in five cohorts and analyzed the relation of structural differences between HLA-B*35 subtypes to the risk of progression to AIDS. Methods Genotyping of HLA class I loci was performed for 850 patients who seroconverted and had known dates of HIV-1 infection. Survival analyses with respect to the rate of progression to AIDS were performed to identify the effects of closely related HLAB* 35 subtypes with different peptide-binding specificities.
Results HLA-B*35 subtypes were divided into two groups according to peptide-binding specificity: the HLA-B*35-PY group, which consists primarily of HLAB* 3501 and binds epitopes with proline in position 2 and tyrosine in position 9; and the more broadly reactive HLA-B*35-Px group, which also binds epitopes with proline in position 2 but can bind several different amino acids (not including tyrosine) in position 9. The influence of HLA-B*35 in accelerating progression to AIDS was completely attributable to HLAB* 35-Px alleles, some of which differ from HLA-B*35- PY alleles by only one amino acid residue.
Conclusions This analysis shows that, in patients with HIV-1 infection, a single amino acid change in HLA molecules has a substantial effect on the rate of progression to AIDS. The different consequences of HLA-B*35-PY and HLA-B*35-Px in terms of disease progression highlight the importance of the epitope specificities of closely related class I molecules in the immune defense against HIV-1
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CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome.
Multiple genome-wide studies have identified associations between outcome of human immunodeficiency virus (HIV) infection and polymorphisms in and around the gene encoding the HIV co-receptor CCR5, but the functional basis for the strongest of these associations, rs1015164A/G, is unknown. We found that rs1015164 marks variation in an activating transcription factor 1 binding site that controls expression of the antisense long noncoding RNA (lncRNA) CCR5AS. Knockdown or enhancement of CCR5AS expression resulted in a corresponding change in CCR5 expression on CD4+ T cells. CCR5AS interfered with interactions between the RNA-binding protein Raly and the CCR5 3' untranslated region, protecting CCR5 messenger RNA from Raly-mediated degradation. Reduction in CCR5 expression through inhibition of CCR5AS diminished infection of CD4+ T cells with CCR5-tropic HIV in vitro. These data represent a rare determination of the functional importance of a genome-wide disease association where expression of a lncRNA affects HIV infection and disease progression
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