Islet Cell-populations in the Pancreas of Type-1 (insulin-dependent) and Type-2 (non-insulin-dependent) Diabetic Subjects

Competitive on-line prediction (also known as universal prediction of individual sequences) is a strand of learning theory avoiding making anystochastic assumptions about the way the observations are generated. The predictor's goal is to compete with a benchmark class of prediction rules, which is often a proper Banach function space. Metric entropy provides a unifying framework for competitive on-line prediction: the numerous known upper bounds on the metric entropy of various compact sets in function spaces readily imply bounds on the performance of on-line prediction strategies. This paper discusses strengths and limitations of the direct approach to competitive on-line prediction via metric entropy, including comparisons to other approaches

Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats

Chinese herbs nephropathy (CHN), a rapidly progressive interstitial fibrosis of the kidney, has been described in approximately 100 young Belgian women who had followed a slimming regimen containing some Chinese herbs. In 4 patients multifocal transitional cell carcinomas (TCC) were observed. Aristolochic acid (AA), suspected as the causal factor of CHN, is a well known carcinogen but its ability to induce fibrosis has never been demonstrated. The objective of this study was to evaluate the latter using doses of AA, durations of intoxication and delays of sacrifice known to yield tumours in rats. We also tested the hypothesis that a possible fibrogenic role of AA was enhanced by the other components of the slimming regimen. Male and female rats were treated orally with 10 mg isolated AA/kg per day for 5 days/week, or with approximately 0.15 mg AA/kg per day 5 days/week contained in the herbal powder together with the other components prescribed in the slimming pills for 3 months. The animals were killed respectively 3 and 11 months later. At sacrifice, animals in both groups had developed the expected tumours but not fibrosis of the renal interstitium, Whether the fibrotic response observed in man is due to species and/or strain related differences in the response to AA or to other factors, remains to be determined. Interestingly, despite the addition of fenfluramine and diethylpropion, two drugs incriminated in the development of valvular heart disease, no cardiac abnormalities were observed