13 research outputs found
Natural Disasters and Service Delivery to Individuals with Severe Mental Illness—Ice Storm 1998
Brain-Derived Neurotropic Factor/TrkB Signaling in the Pathogenesis and Novel Pharmacotherapy of Schizophrenia
Risk and Protective Pathways to Peer Victimization from Infancy to Adolescence: Role of Fathers
Functional Polymorphism of the Human Multidrug Resistance Gene (MDR1) and Polydipsia–Hyponatremia in Schizophrenia
Evaluation of the Incidence of Leukopenia and Agranulocytosis in Patients Receiving Combined Clozapine and Other Antipsychotics
Source location of air pollution and cardiac autonomic function: Trajectory cluster analysis for exposure assessment
Almost All Antipsychotics Result in Weight Gain: A Meta-Analysis
INTRODUCTION: Antipsychotics (AP) induce weight gain. However, reviews and meta-analyses generally are restricted to second generation antipsychotics (SGA) and do not stratify for duration of AP use. It is hypothesised that patients gain more weight if duration of AP use is longer. METHOD: A meta-analysis was conducted of clinical trials of AP that reported weight change. Outcome measures were body weight change, change in BMI and clinically relevant weight change (7% weight gain or loss). Duration of AP-use was stratified as follows: ≤6 weeks, 6-16 weeks, 16-38 weeks and >38 weeks. Forest plots stratified by AP as well as by duration of use were generated and results were summarised in figures. RESULTS: 307 articles met inclusion criteria. The majority were AP switch studies. Almost all AP showed a degree of weight gain after prolonged use, except for amisulpride, aripiprazole and ziprasidone, for which prolonged exposure resulted in negligible weight change. The level of weight gain per AP varied from discrete to severe. Contrary to expectations, switch of AP did not result in weight loss for amisulpride, aripiprazole or ziprasidone. In AP-naive patients, weight gain was much more pronounced for all AP. CONCLUSION: Given prolonged exposure, virtually all AP are associated with weight gain. The rational of switching AP to achieve weight reduction may be overrated. In AP-naive patients, weight gain is more pronounced