Performing high speed tests with ENIFAIR powered nacelles in the S1MA wind-tunnel

Communication to : Workshop on European-research on aerodynamic engine / airframe integration for transport aircraft, Braunschweig (Germany), September 26-27, 2000Available from INIST (FR), Document Supply Service, under shelf-number : 22419, issue : a.2000 n.179 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

Gene Expression Profiling In Genetic Animal Models Of Provide Elements To Unveil The Molecular Mechanisms Underlying Epileptogenesis In Rodents [a Caracterização Do Perfil De Expressão Gênica Em Larga Escala Em Modelos Genéticos De Epilepsia Fornece Elementos Para Entender Os Mecanismos Envolvidos Na Epileptogênese Em Roedores]

Objective: The objective of this study was to characterize and compare the genetic profile of two rodent models of epilepsy (Wistar Audiogenic Rat - WAR and rats with generalized epilepsy with absence seizures-GEAS) using gene expression analysis Methods: We used microarray technology for gene expression analysis. Results: The analysis of gene expression profiles in WAR showed among genes up-regulated Neurod1, involved in the development of the cochlear duct. In addition, we found significant differences in gene expression of Apbb1, Foxg1 and Scn1A. GEAS rats had differentially expressed genes related to the development of central nervous system, as well as genes involved in the MAPK pathway, transcription factors, neuronal migration and apoptosis. Conclusion: This study may help to clarify the underlying molecular mechanism that leads to the predisposition to seizures in these animals. Our results indicate the activation of distinct molecular pathways in both models.1825052Aicard, J., Course and prognosis of certain chidhood epilepsies with predominantly myoclonic seizures (1980) Advances in Epileptology. The Xth Epilepsy International Symposim, pp. 159-163. , Wada JA, Penry JK e cols. New York: RavemAndré, E.S., Electrophysiological characterization of a new form of spontaneous epilepsy in Wistar rats (1999) Epilepsia, 40 (SUPPL. 2)Bruno-Neto, R., Caracterização de uma nova forma de epilepsia espontânea em ratos Wistar (1999) XIV FESBE, AnaisBruno-Neto, R., André, E.S., Pellarin, L., Hilário, F.K., Valle, A.C., Timo-Iaria, C., Electrophysiological characterization of a new form of spontaneous epilepsy in Wistar rats (1999) 23rd International Epilepsy Congress, Prague, Czech RepublicDoretto, M.C., Fonseca, C.G., Lobo, R.B., Terra, V.C., Oliveira, J.A., Garcia-Cairasco, N., Quantitative study of the response to genetic selection of the WistarAudiogenic Rat strain (WAR) (2003) Behav Genet, 33 (1), pp. 33-42Garcia-Cairasco, N., Sabbatini, R., Role of the substantianigra in audiogenic seizures: A neuroethological analysis in the rat (1983) Braz J Med Biol Res, 16 (2), pp. 171-183Gitaí, D.L., Martinelli, H.N., Valente, V., Pereira, M.G., Oliveira, J.A., Elias, C.F., Bittencourt, J.C., Paçó-Larson, M.L., Increased expression of GluR2-flip in the hippocampus of the Wistaraudiogenic rat strain after acute and kindled seizures (2010) Hippocampus, 20, pp. 125-133Jobe, P.C., Brown, R.D., Dailey, J.W., Effect of Ro 4-1284 on audiogenic seizure susceptibility and intensity in epilepsy-prone rats (1981) Life Sci, 28 (18), pp. 2031-2038Kovács, Z., Suppression of spike-wave discharge activity and c-fos expression by2-methyl-4-oxo-3H-quinazoline-3-acetyl piperidine (Q5) in vivo (2007) Neuroscience Letters, 423, pp. 73-77Mesquita, F., Aguiar, J.F., Oliveira, J.A., Garcia-Cairasco, N., Varanda, W.A., Electrophysiological properties of cultured hippocampal neurons from WistarAudiogenic rats (2005) Brain Res Bul, 65, pp. 177-183Moraes, M.F., Galvis-Alonso, O.Y., Garcia-Cairasco, N., Audiogenic kindling in the Wistar rat: A potential model for recruitment of limbic structures (2000) Epilepsy Research, 39, pp. 251-259Nunes, P.V., Valle, A.C., Timo-Iaria, C., Epileptogenic potentials recorded from the cerebellar cortex in rats (1999) Epilepsia, 40, p. 132. , 23th International Epilepsy Congress, Prague, Czech Republi

Null leukemia inhibitory factor receptor (LIFR) mutations in Stuve-Wiedemann/Schwartz-Jampel type 2 syndrome.

Stuve-Wiedemann syndrome (SWS) is a severe autosomal recessive condition characterized by bowing of the long bones, with cortical thickening, flared metaphyses with coarsened trabecular pattern, camptodactyly, respiratory distress, feeding difficulties, and hyperthermic episodes responsible for early lethality. Clinical overlap with Schwartz-Jampel type 2 syndrome (SJS2) has suggested that SWS and SJS2 could be allelic disorders. Through studying a series of 19 families with SWS/SJS2, we have mapped the disease gene to chromosome 5p13.1 at locus D5S418 (Zmax=10.66 at theta =0) and have identified null mutations in the leukemia inhibitory factor receptor (LIFR or gp190 chain) gene. A total of 14 distinct mutations were identified in the 19 families. An identical frameshift insertion (653_654insT) was identified in families from the United Arab Emirates, suggesting a founder effect in that region. It is interesting that 12/14 mutations predicted premature termination of translation. Functional studies indicated that these mutations alter the stability of LIFR messenger RNA transcripts, resulting in the absence of the LIFR protein and in the impairment of the JAK/STAT3 signaling pathway in patient cells. We conclude, therefore, that SWS and SJS2 represent a single clinically and genetically homogeneous condition due to null mutations in the LIFR gene on chromosome 5p13

Lost in translation: exploring the link between HRM and performance in healthcare

Using data collected in 2004 from 132 Victorian (Australia) public healthcare providers, comprising metropolitan and regional hospital networks, rural hospitals and community health centres, we investigated the perceptions of HRM from the experiences of chief executive officers, HR directors and other senior managers. We found some evidence that managers in healthcare organisations reported different perceptions of strategic HRM and a limited focus on collection and linking of HR performance data with organisational performance management processes. Using multiple moderator regression and multivariate analysis of variance, significant differences were found in perceptions of strategic HRM and HR priorities between chief executive officers, HR directors and other senior managers in the large organisations. This suggested that the strategic human management paradigm is lost in translation, particularly in large organisations, and consequently opportunities to understand and develop the link between people management practices and improved organisational outcomes may be missed. There is some support for the relationship between strategic HRM and improved organisational outcomes. Implications of these findings are drawn for managerial practice