Hyperacute Graft-vs.-Host Disease After Related HLA-Identical Umbilical Cord Blood Transplantation

haGVHD has been described following bone marrow and peripheral blood stem cell transplantation and in a single case who received unrelated HLA mismatched CB. An unusual case of haGVHD following HLA 6/6-matched sibling CBT in a child with AML is presented. The development of haGVHD in a fully matched CBT and without precipitating factors may suggest the role of still undefined and perhaps individual contributory factors

Muscle function-dependent sarcopenia and cut-off values of possible predictors in community-dwelling Turkish elderly: Calf circumference, midarm muscle circumference and walking speed

© 2015 Macmillan Publishers Limited. All rights reserved.Background/Objectives:The aim of this study was to determine the prevalence of muscle strength-based sarcopenia and to determine possible predictors.Subjects/Methods:This is a cross-sectional population-based study in the community-dwelling Turkish elderly. Anthropometric measurements, namely body height, weight, triceps skin fold (TSF), mid upper arm circumference (MUAC), waist circumference (WC) and calf circumference (CC), were noted. The midarm muscle circumference (MAMC) was calculated by using MUAC and TSF measurement. Sarcopenia was assessed, adjusted for body mass index (BMI) and gender, according to muscle strength. Physical performance was determined by 4 m walking speed (WS; m/s). The receiver operating curve analysis was performed to determine cut-offs of CC, MAMC and 4 m WS.Results:A total of 879 elderly subjects, 50.1% of whom were female, were recruited. The mean handgrip strength (HGS) and s.d. was 24.2 (8.8) kg [17.9 (4.8) female, 30.6 (7.1) male]. The muscle function-dependent sarcopenia was 63.4% (female 73.5%, male 53.2%). The muscle mass-dependent sarcopenia for CC (<31 cm) and MAMC(<21.1 cm in males, <19.9 cm in females) was 6.7% and 7.3%, respectively. The prevalence of low 4 m WS (≤0.8 m/s) was 81.8% (91.3% in females and 72.3% in males, respectively). We compared MAMC, CC and 4 m WS and found that AUC for 4 m WS was the best predictor of sarcopenia.Conclusions:An adequate muscle mass may not mean a reliable muscle function. Muscle function may describe sarcopenia better compared with muscle mass. The CC, MAMC and 4 m WS cut-offs may be used to assess sarcopenia in certain age groups

Validity of simplified nutritional appetite questionnaire for Turkish community-dwelling elderly and determining cut-off according to mini nutritional assessment

© 2019Background/Objectives: The aim of this study was to determine a cut-off value for the SNAQ according to both the MNA long and MNA short forms and to assess whether the SNAQ can predict malnutrition or risk of malnutrition in the elderly. Subjects/Methods: Nutritional status was assessed both by the Mini Nutritional Assessment (MNA) long and short forms. All demographic characteristics, mental status, depressive mood, functional status, and frailty were determined. Receiver operating characteristic (ROC) curves were used to calculate the cut-off of the SNAQ according to both the MNA long and short forms for malnutrition or risk of malnutrition. Reliability and validation of the SNAQ was analysed. Results: We included 905 community-dwelling elderly, but those with middle-stage dementia (MMSE score <18, n = 30) were excluded. The mean age ± standard deviation (SD) was 71.4 ± 5.5 years (49.3% female and 50.7% male). The prevalence of well-nourished, risk of malnutrition or malnutrition were 55.2%, 44.8%, respectively according to the MNA-long form. The prevalence of elderly at risk of future weight loss (SNAQ score of ≤14) was 31.0% (n = 268; 66.0% female, 34.0% male). The area under the curve (AUC) for SNAQ was 0.725 (95% CI 0.690–0.760). The cut-off value of the SNAQ, according to both the MNA long and short forms, was 14 (sensitivity; 50%, 50% and specificity; 84%, 82%, respectively). The Cronbach's alpha reliability coefficient of SNAQ for internal consistency was 0.639. Conclusion: The SNAQ was reliable and valid as an appetite screening tool in community-dwelling Turkish elderly

The prevalence of frailty and related factors in community-dwelling Turkish elderly according to modified Fried Frailty Index and FRAIL scales

The purpose of this study is to determine the prevalence of frailty with the Fried Frailty Index (FFI) and FRAIL scales (Fatigue, Resistance, Ambulation, Illness, Low weight) and also its associated factors in the community-dwelling Turkish elderly

Nutritional status and related risk factors which may lead to functional decline in community-dwelling Turkish elderly

Results: A total of 845 elderly were included. Their mean age and standard deviation (SD) of age were 71.6 (5.6) (52% were male). The mean and SD of MNA score was 23 (3.0), of these 42.2% were at risk of malnutrition (MNR) and 3.3% were malnutrition (MN). In logistic regression analysis, odds of low income (OR: 0.5, 95% CI: 0.321-0.849), decreased mid-upper arm circumference (MUAC) (OR: 0.9, 95% CI: 0.873- 0.973), decreased waist circumference (WC) (OR: 0.9, 95% CI: 0.970-0.999), increased depressive mood (OR: 0.26, 95% CI0.176: 0.389), diabetes mellitus (OR: 1.7, 95% CI: 1.178-2.601), living alone (OR: 1.9, 95% CI: 1.189-3.150) and increased 4-m walking speed (m/s) (OR: 1.1, 95% CI: 1.05-1.248) were independently associated with possible poor nutrition. Conclusions: Significant risk factors for poor nutrition can be grouped as clinical conditions; depressive mood and diabetes mellitus, anthropometric measurements; WC and MUAC, social factors; low income and living alone, functionality; increased 4-m walking speed (m/s). © 2014 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved.Purpose: The objective of this study is to assess the nutritional status in community-dwelling elderly and to describe risk factors which may cause poor nutrition related functional decline.Methods: This is a cross-sectional population-based study in urban area where more than one million population lives. Community-dwelling elderly were sampled as 1/100 from this population. Nutritional status was assessed by the Mini Nutritional Assessment (MNA). All demographic characteristics and risk factors which may contribute to functional decline were reviewed. Logistic regression analyses were performed to identify independent risk factors over nutritional status

Which Frailty Scale Predicts 4-Year Mortality in Community-Dwelling Turkish Elderly Better: The FRAIL Scale or the Fried Frailty Index?

Objective: Frailty is a prevalent geriatric syndrome that can indicate mortality in the elderly. The aim of this study was to determine if there was an association between frailty and 4-year mortality in the community-dwelling Turkish older people

The Relationship Between Daily Living Activities and Cognitive Function in the Elderly: Cross-Sectional Study

Objective: This study aimed to describe the relationship between activities of daily living and cognitive function community-dwelling elderly in an urban area