6 research outputs found
VacunaciĂłn antigripal y protecciĂłn del paciente crĂtico: responsabilidad de los profesionales sanitarios
International collaborative study on standardization of bacterial sensitivity to fosfomycin
An international collaborative study was undertaken involving 6 working groups to correlate the zone sizes obtained with 50 μg fosfomycin+25 μg glucose-6-phosphate (G6P) and 50 μg fosfomycin + 50 μg G6P/disc with the MICs in the presence of 25 mg G6P/litre. The recommendations of the ICS for the MIC and disc diffusion methods were followed and Oxoid Mueller-Hinton agar was used. The regression lines obtained with the method of least squares show that the best correlation coefficient (r= -0.8227) corresponds to the disc with 50 μg fosfomycin + 50 μg G6P. Considering both the pharmacokinetics of fosfomycin after intravenous administration of 2 or 4 g and the distribution of sensitive bacterial populations, two breakpoints were established at MIC values of 16 and 64 mg/1 corresponding to zone sizes of 18 and 12 mm, respectively. © 1983 The British Society for Antimicrobial Chemotherapy.SCOPUS: ar.jinfo:eu-repo/semantics/publishe