2D-BN nanoparticles as a spectroscopic marker and drug delivery system with protection properties

An application of 2D-BN nanoparticles as a spectroscopic marker, weak luminescent marker and anticancer drug (doxorubicin, DOX) delivery system with protection properties was studied for the LNCaP strains of cancer cells using FTIR and Raman spectroscopy for analysing the cancer cells, cells with BN, the cancer cells with DOX, and the cancer cells with BN nanoparticles loaded by DOX. Study of IR absorption and Raman spectra of the LNCaP strains of cancer cells incubated with 2D-BN nanoparticles for 1 hour showed that the 2D-BN nanoparticles could pass through the cell membrane and localize inside the membrane or close to the membrane in the cytoplasm of the cells. We registered the spectra of the disturbed lipids during the DOX-2D-BN passing through the membrane. After incubation for 2 hours and more, spectral changes in other structural components of the cell (nuclei, cytoplasm, mitochondria) can be registered. Confocal microscopy showed that a gold nanostructured support enhances the fluorescence of the cancer cells with 2D-BN as well as that with DOX, however the double action of 2D-BN and DOX on the cancer cells aggravates the emission property of the studied system. An MTT test showed that the toxicity of DOX on the 2D-BN nanoparticles is less than that on the reference cells, and at the same time the efficiency of the DOX action on the cancer cells does not change

Comparative analysis of the effect of enhancement of IR signals of biomolecules adsorbed on single wall carbon nanotubes and graphene nano plates

We thank for financial assistance Project STCU 5525 (2012-2013), Ukrainian- German project № M366 (2011-2012), Russian-Ukrainian Project (2012-2013)

Models of general circulation of the atmosphere and oceans in forecasting changes in the regional climate of Ukraine in the 21st century.

For the first time quantitative characteristics of probable climate changes in Ukraine during the 21st century for three SRES emission scenarios B1, A1B and A2 have been obtained from an analysis of 84 runs of 10 Atmosphere-Ocean General Circulation Models (AOGCM) used for AR4 IPCC-2007. The analysis of AOGCM’s results has shown that projected differences of the averaged over the territory of Ukraine surface temperatures of the ending and the first decades of the 21st century will be in limits: B1 - from 0,7 to 3,0 °С with ensemble mean 2,0±0,8 °С; А1В - from 2,4 to 4,2 °С with mean 3,1±0,7 °С; and А2 - from 2,6 to 4,6 °С with mean 3,8±0,8 °С. There is not such an agreement for precipitation variations during the 21st century between AOGCMs, and precipita-tion changes vary from -23,4 to +11,6 % up to the end of the 21st century comparing to 2001-2010. Therefore, more detailed precipitation change projections for the territory of Ukraine could be made only with regional climate models. The most rapid changes of surface temperature and precipita-tion have been obtained in AOGCMs for А2 scenario, the slowest - for В1 respectively. The model ECHAM5/MPI-OM has been determined as the most successful AOGCM in simulation of climate of Ukraine because statistical analysis has shown that differences of its results with ensemble mean were minimal. Results of this model could be recommended as initial and boundary conditions for simulation of climate of Ukraine with regional climate models