Charge inversion under plasma-nanodroplet reaction conditions excludes Fischer esterification for unsaturated fatty acids: a chemical approach for type II isobaric overlap

The fusion of nonthermal plasma with charged nanodroplets enables selective esterification of saturated fatty acids, which is utilized to overcome challenges associated with type II isobaric overlap in direct infusion mass spectrometry.</jats:p

Determining the Load on the Long-based Structure of the Platform Car with Elastic Elements in Longitudinal Beams

This paper reports a study into the dynamic loading and strength of an improved carrying structure of the platform car. A special feature of the car is the presence of elastic elements in the main longitudinal beams of the frame. This could improve the fatigue strength of the carrying structure of the platform car under operational modes. Mathematical modeling was carried out to determine the dynamic load on the carrying structure of the platform car. The fluctuations of bouncing were taken into consideration. It has been established that the vertical acceleration of the carrying structure of the platform car without cargo is about 2.0&nbsp;m/s2 (0.2&nbsp;g). In this case, the vertical accelerations that act on the carrying structure of the platform car are lower by 15&nbsp;% as compared to the prototype wagon. The main indicators of strength of the bearing structure of the platform car have been determined. The calculation was carried out using a method of finite elements employing the software suite SolidWorks Simulation (France). When compiling the estimation scheme, it was taken into consideration that the carrying structure of the platform car was loaded with four containers the size of 1SS. In this case, the maximum equivalent stresses occur in the region of interaction between a pivot beam and spreads and are 254.0&nbsp;MPa. That warrants the strength of the carrying structure of the platform car. The numerical values of acceleration of the carrying structure of the platform car have been determined, as well as the fields of their location, by applying computer simulation. The fatigue strength and oscillation eigenfrequencies in the carrying structure of the platform car have been investigated; their designed service time has been estimated. The reported research would contribute to building innovative structures of platform cars, as well as to improving the efficiency of combined transportation

Defining Patterns in the Dynamic Load and Strength of the Bearing Structure of A Covered Freight Car with A Filler in the Girder Beam

This paper reports a study into determining the dynamic load and strength of the bearing structure of a covered freight car under operational modes. A feature of the freight car's bearing structure is that the girder beam has a closed cross-section. To reduce the dynamic load of the frame, the girder beam is filled with a material with viscoelastic properties. Such a solution could contribute to the transformation of the kinetic energy of impact (due to jerk, stretching, compression) into work of viscoelastic friction forces, and, consequently, to reducing the load on the bearing structure. To substantiate the proposed improvement, the dynamic load on the bearing structure of a covered freight car was mathematically modeled. The calculation was performed for the case of joint impacts at shunting. The study was carried out in a flat coordinate system. It was established that the maximum accelerations acting on the bearing structure of a covered freight car were about 37 m/s2. The calculated acceleration value is 3.2 % lower than that obtained for the bearing structure of a covered freight car without filler. The results of calculating the strength of the load-bearing structure of a covered freight car are given. In this case, a finite-element method was applied. The maximum equivalent stresses occur in the zones of interaction between the girder beam and the pivot beams, and amount to 319.5 MPa, which is 8 % lower than permissible. The calculation was also performed regarding other operational modes of loading the freight car's bearing structure. The model of the dynamic load on the bearing structure of a covered freight car was verified according to the F-criterion. The research reported here could contribute to designing innovative rolling stock structures, thereby improving the efficiency of their operation

The Gigabit Link Interface Board (GLIB), a flexible system for the evaluation and use of GBT-based optical links

The Gigabit Link Interface Board (GLIB) is an evaluation platform and an easy entry point for users of high speed optical links in high energy physics experiments. Its intended use ranges from optical link evaluation in the laboratory to control, triggering and data acquisition from remote modules in beam or irradiation tests. The GLIB is an FPGA-based Advanced Mezzanine Card (AMC) conceived to serve a small and simple system residing either inside a Micro Telecommunications Computing Architecture (mu TCA) crate, or on a bench with a link to a PC. This paper presents the architecture of the GLIB, its features as well as examples of its use in different setups

A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity

Due to their crucial role in tumor immunity, NK cells have quickly became a prime target for immunotherapies, with the adoptive transfer of NK cells and the use of NK cell engagers quickly moving to the clinical stage. On the other hand, only a few studies have focused on small molecule drugs capable of unleashing NK cells against cancer. In this context, repurposing small molecules is an attractive strategy to identify new immunotherapies from already approved drugs. Here, we developed a new platform to screen small molecule compounds based on a high-throughput luciferase-release cytotoxicity assay. We tested 1200 FDA approved drugs from the Prestwick Chemical Library, to identify compounds that increase NK cells’ cytotoxic potential. We found that the antibiotic colistin sulfate increased the cytotoxicity of human NK cells towards cancer cells. The effect of colistin was short lived and was not observed when NK cells were pretreated with the drug, showing how NK cell activity was potentiated only when the compound was present at the time of recognition of cancer cells. Further studies are needed to uncover the mechanism of action and the pre-clinical efficacy of colistin sulfate in mouse cancer models