Prevalence of adrenal masses in Japanese patients with type 2 diabetes mellitus

<p>Abstract</p> <p>Introduction</p> <p>To date, there have been no reports on the prevalence of adrenal masses in type 2 diabetic patients. The present study aimed to evaluate the prevalence of adrenal incidentaloma in type 2 diabetic patients in Japan.</p> <p>Subjects</p> <p>We retrospectively evaluated the presence of adrenal masses using abdominal CT scans in 304 type 2 diabetic patients. In those with adrenal masses, we examined the hormone production capacity of the adrenal mass.</p> <p>Results</p> <p>Fourteen patients (4.6%) had an adrenal mass. Hormonal analysis identified one case as having subclinical Cushing's syndrome, two with primary aldosteronism. Eleven cases had non-functioning masses.</p> <p>Discussion</p> <p>The reported prevalence of adrenal incidentaloma in normal subjects is 0.6-4.0% in abdominal CT scan series. Our results show a relatively high prevalence of adrenal tumors in diabetic patients. On the other hand, the frequency of functional adenoma in diabetic patients is 21.4%, which is similar to that of normal subjects.</p> <p>Conclusion</p> <p>Although further studies are needed to evaluate the prevalence of adrenal tumors in diabetic patients, our data suggest that evaluation of the presence of adrenal masses may be needed in patients with type 2 diabetes mellitus.</p

Natural Variation in the Thermotolerance of Neural Function and Behavior due to a cGMP-Dependent Protein Kinase

Although it is acknowledged that genetic variation contributes to individual differences in thermotolerance, the specific genes and pathways involved and how they are modulated by the environment remain poorly understood. We link natural variation in the thermotolerance of neural function and behavior in Drosophila melanogaster to the foraging gene (for, which encodes a cGMP-dependent protein kinase (PKG)) as well as to its downstream target, protein phosphatase 2A (PP2A). Genetic and pharmacological manipulations revealed that reduced PKG (or PP2A) activity caused increased thermotolerance of synaptic transmission at the larval neuromuscular junction. Like synaptic transmission, feeding movements were preserved at higher temperatures in larvae with lower PKG levels. In a comparative assay, pharmacological manipulations altering thermotolerance in a central circuit of Locusta migratoria demonstrated conservation of this neuroprotective pathway. In this circuit, either the inhibition of PKG or PP2A induced robust thermotolerance of neural function. We suggest that PKG and therefore the polymorphism associated with the allelic variation in for may provide populations with natural variation in heat stress tolerance. for's function in behavior is conserved across most organisms, including ants, bees, nematodes, and mammals. PKG's role in thermotolerance may also apply to these and other species. Natural variation in thermotolerance arising from genes involved in the PKG pathway could impact the evolution of thermotolerance in natural populations

Desigualdades socioeconomicas e demograficas como fatores de risco para a artrite autorreferida: estudo de base populacional em adultos no Sul do Brasil

Abstract published in English and Portuguese English title: Socioeconomic and demographic inequalities as risk factors for self-reported arthritis: a population-based study in southern BrazilThe study aimed to estimate prevalence of self-reported arthritis or rheumatism and associated factors. This was a cross-sectional population-based study in Florianopolis, Santa Catarina State, Brazil, with 1,720 adults ranging from 20 to 59 years of age. Presence of self-reported arthritis or rheumatism was analyzed with a hierarchical approach, considering demographic, socioeconomic, and behavioral variables and use of health services. Logistic regression was used to evaluate the association between the outcome and independent variables. Prevalence of self-reported arthritis or rheumatism was 7.7% (95%CI: 6.4-8.9). The odds of self-reported arthritis were twice as high in women, and increased self-reported arthritis was directly associated with BMI > 30kg/m2 and increasing age and inversely proportional to schooling. Self-reported arthritis or rheumatism was higher in this sample than in Brazilian adults in general in 2008. The results suggest the need to plan public health policies to address this problem. = Estimar a prevalência de artrite ou reumatismo autorreferido e os fatores associados. Realizou-se um estudo transversal de base populacional em Florianópolis, Santa Catarina, Brasil, com 1.720 adultos entre 20 e 59 anos. A presença de artrite ou reumatismo autorreferido foi analisada por meio do modelo hierárquico de determinação no nível demográfico, socioeconômico, comportamental e uso de serviços de saúde. Utilizou-se análise de regressão logística para avaliar a associação entre as variáveis. A prevalência de artrite ou reumatismo autorreferido foi de 7,7% (IC95%: 6,4-8,9). A chance de artrite ou reumatismo autorreferido foi duas vezes maior entre as mulheres, maior entre aqueles com índice de massa corporal (IMC) > 30kg/m2,diretamente proporcional à idade e inversamente proporcional à escolaridade. A prevalência de artrite ou reumatismo autorreferido foi maior do que a estimativa nacional no ano de 2008. Essa realidade sugere a necessidade de um planejamento de políticas públicas voltado para esse agravo de saúde.Rafael Santos Gomes, Karen Glazer Pere

Inversion symmetry and bulk Rashba effect in methylammonium lead iodide perovskite single crystals

Methylammonium lead iodide perovskite (MAPbI_3) exhibits long charge carrier lifetimes that are linked to its high efficiency in solar cells. Yet, the mechanisms governing these unusual carrier dynamics are not completely understood. A leading hypothesis—disproved in this work—is that a large, static bulk Rashba effect slows down carrier recombination. Here, using second harmonic generation rotational anisotropy measurements on MAPbI_3 crystals, we demonstrate that the bulk structure of tetragonal MAPbI_3 is centrosymmetric with I4/mcmspace group. Our calculations show that a significant Rashba splitting in the bandstructure requires a non-centrosymmetric lead iodide framework, and that incorrect structural relaxations are responsible for the previously predicted large Rashba effect. The small Rashba splitting allows us to compute effective masses in excellent agreement with experiment. Our findings rule out the presence of a large static Rashba effect in bulk MAPbI_3, and our measurements find no evidence of dynamic Rashba effects