Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system.

Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS

A common volatilization trend in Transantarctic Mountain and Australasian microtektites: Implications for their formation model and parent crater location

We studied the variations of the volatile major elements Na and K in Transantarctic Mountain microtektites and Australasian microtektites with distance from the putative source crater location in Indochina. The dataset includes 169 normal-type Australasian microtektites (101 from this study and 68 from the literature) from 24 deep-sea sediment cores up to 8000km from Indochina, and 54 Transantarctic Mountain microtektites from northern Victoria Land, 11000km due southeast of Indochina. Normal-type (MgO8000km are 4.27±0.67wt.% (n=84), 3.20±1.21wt.% (n=50), 2.10±0.25wt.% (n=35) and 1.25±0.25wt.% (n=54), respectively. The trend highlights a relationship between increasing loss of volatiles in microtektites with longer trajectories and higher temperature-time regimes which should be taken into account in microtektite formation modeling. The trend is consistent with a previous hypothesis that Transantarctic Mountain microtektites belong to the Australasian strewn field and that Indochina is the target region for the parent catastrophic impact

DDE-NBSR Status Report of Conceptual Design Activities

The Design Demonstration Experiment for the National Bureau of Standard Reactor (DDE-NBSR) is intended to facilitate Low Enriched Uranium (LEU) conversion of the NBSR by demonstrating the performance and fabrication of the LEU fuel element design through an irradiation test in the Advanced Test Reactor center flux trap. At the time this report was prepared the resources for furthering DDE design work were expected to be postponed. As such, the conceptual design effort to date is summarized herein in order to provide the status of key objectives, notable results, and provisions for future design work. These demonstrate that the DDE-NBSR design effort is well on the path to producing a suitable irradiation experiment, but also exhibits several challenges for which timely resolution is recommend in order to facilitate success of the irradiation campaign and ultimate conversion of the NBSR

The Impact-Flood Connection: Does It Exist?

https://deepblue.lib.umich.edu/bitstream/2027.42/155790/1/Deutsch_et_al_1994_Impact-flood_connection.pd