Annotation Enrichment Analysis: An Alternative Method for Evaluating the Functional Properties of Gene Sets

Gene annotation databases (compendiums maintained by the scientific community that describe the biological functions performed by individual genes) are commonly used to evaluate the functional properties of experimentally derived gene sets. Overlap statistics, such as Fisher's Exact Test (FET), are often employed to assess these associations, but don't account for non-uniformity in the number of genes annotated to individual functions or the number of functions associated with individual genes. We find FET is strongly biased toward over-estimating overlap significance if a gene set has an unusually high number of annotations. To correct for these biases, we develop Annotation Enrichment Analysis (AEA), which properly accounts for the non-uniformity of annotations. We show that AEA is able to identify biologically meaningful functional enrichments that are obscured by numerous false-positive enrichment scores in FET, and we therefore suggest it be used to more accurately assess the biological properties of gene sets

The New Kid on the Block: IFS Informed Financial Therapy

Internal Family Systems℠ (IFS) therapy is an evidenced-based therapeutic (EBT) tool used to treat various mental health disorders and non-clinical issues. IFS is a promising new approach to building healthy financial behaviors when combined it with financial therapy. During a financial discussion, beliefs, money scripts, and stories around the client’s money history are expressed and are then explored using IFS protocols. IFS provides the financial therapist with a tool that has a high probability of being effective at helping clients access their hidden extreme beliefs, emotions, and stories around money and offers the hope of making changes resulting in lasting positive financial behaviors. The initial results of using IFS Informed Financial Therapy℠ with a small pool of clients were promising in helping them address and change problematic financial behaviors. Obtaining IFS certification is possible for most financial therapists. It gives them expertise in an evidence-based model of therapy that can enhance the financial therapy process, which has broad implications

ARL Digital Scholarship Institute

This poster reflects on the Association of Research Libraries’ (ARL) upcoming inaugural week-long Digital Scholarship Institute for library professionals. Held in June 2017 at Boston College, the Institute introduced librarians and staff who are not currently involved in digital scholarship to the methodologies and considerations of such work. This multi-institutional initiative will provide an opportunity for broader transformation in the academic library ecosystem at the level necessary to create a strong community of practice around digital scholarship wor

Australian pharmacists' perceptions and practices in travel health

Worldwide, pharmacists are playing an increasing role in travel health, although legislation and funding can dictate the nature of this role, which varies from country to country. The aim of this study was to explore the current and potential future practices in travel health for pharmacists in Australia, as well as the perceived barriers, including training needs, for the provision of services. A survey was developed and participation was sought from a representative sample of Australian pharmacists, with descriptive statistics calculated to summarise the frequency of responses. A total of 255 participants, predominantly female (69%), below 50 years (75%) and registered less than 30 years completed the survey. Although over two-thirds (68%) provided travel-related advice in their current practice, the frequency of advice provision was low (less than 2 travellers per week) and limited to responding to travellers questions. Although Australian pharmacists are currently unable to administer travel vaccines and prescription only medications without prescription, they still consider travel health to be an appropriate role and that their clients would seek travel health advice from pharmacies if offered. Currently, key roles for Australian pharmacists are advising travellers who do not seek advice from other practitioners, reinforcing the advice of other health practitioners and referring travellers needing vaccinations and antimalarials. In order to expand these services, the barriers of workload, time, staffing and the need for training in travel health need to be addressed. In summary, the travel health services provided by pharmacies in Australia still have a way to go before they match the services offered by pharmacies in some other countries, however Australian pharmacist are keen to further develop their role in this area

The power of discussion : Support for women at the fungal Gordon Research Conference

We would like to thank Abigail LaBella for sharing the pictures taking during the session and Felicia Wu for her suggestions. We are grateful to all the colleagues that helped leading the discussion groups and all the participants of the session.Peer reviewedPostprin

A Social Model for Health Promotion for an Aging Population: Initial Evidence on the Experience Corps Model

This report evaluates whether a program for older volunteers, designed for both generativity and health promotion, leads to short-term improvements in multiple behavioral risk factors and positive effects on intermediary risk factors for disability and other morbidities. The Experience Corps® places older volunteers in public elementary schools in roles designed to meet schools\u27 needs and increase the social, physical, and cognitive activity of the volunteers. This article reports on a pilot randomized trial in Baltimore, Maryland. The 128 volunteers were 60-86 years old; 95% were African American. At follow-up of 4-8 months, physical activity, strength, people one could turn to for help, and cognitive activity increased significantly, and walking speed decreased significantly less, in participants compared to controls. In this pilot trial, physical, cognitive, and social activity increased, suggesting the potential for the Experience Corps to improve health for an aging population and simultaneously improve educational outcomes for children