65 research outputs found
Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system.
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS
Collaborative learning in pre‐service teacher education: an exploratory study on related conceptions, self‐efficacy and implementation
Neurogenic Pulmonary Oedema in Man: Aetiology and Management with Vasodilators based on Haemodynamic Studies
Spin-forbidden transitions between 2p 2 and 2s2p states in the beryllium isoelectronic sequence
INHIBITION OF GLYCOALKALOID FORMATION IN POTATO TUBERS BY THE SPROUT INHIBITOR, MALEIC HYDRAZIDE
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