8,721 research outputs found
Inhibition of monocyte complement receptor enhancement by low molecular weight material from human lung cancers
We have studied the effect of dialysates from lung cancer homogenates to alter both the expression of complement (C3b) receptors per se and also to inhibit leucoattractant-induced enhancement of complement rosettes on monocytes from healthy individuals. Enhancement and enhancement-inhibition by tumour extracts were compared with material derived from normal lung excised from distance from the tumour. There was no significant difference between tumour homogenate (TH) and normal lung homogenate (NLH) in terms of enhancement of complement rosettes per se. In contrast, TH produced a dose- and time-dependent inhibition of leucoattractant-induced enhancement of C3b rosettes which was significantly different from that obtained with NLH. This enhancement-inhibition was observed with four undifferentiated, four squamous and three adenocarcinomas of lung. The degree of enhancement-inhibition was not related to the type of tumour or varying accompanying histological features such as necrosis and the degree of infiltration with inflammatory cells. Following gel filtration on Sephadex G-50 each type of cancer gave a major peak of inhibitory activity which eluted with molecules having an apparent molecular size of approximately 3,000 daltons. A second larger peak (8,000-10,000 daltons) was also detected with extracts from the undifferentiated and adenocarcinomas. These results support previous findings, mainly from experimental animals, indicating that 'anti-macrophage/monocyte principles' are elaborated from certain tumour types
Regulatory Dynamics on Random Networks: Asymptotic Periodicity and Modularity
We study the dynamics of discrete-time regulatory networks on random
digraphs. For this we define ensembles of deterministic orbits of random
regulatory networks, and introduce some statistical indicators related to the
long-term dynamics of the system. We prove that, in a random regulatory
network, initial conditions converge almost surely to a periodic attractor. We
study the subnetworks, which we call modules, where the periodic asymptotic
oscillations are concentrated. We proof that those modules are dynamically
equivalent to independent regulatory networks.Comment: 23 pages, 3 figure
X-ray rocking curve study of Si-implanted GaAs, Si, and Ge
Crystalline properties of Si-implanted GaAs, Si, and Ge have been studied by Bragg case double-crystal x-ray diffraction. Sharp qualitative and quantitative differences were found between the damage in GaAs on one hand and Si and Ge on the other. In Si and Ge the number of defects and the strain increase linearly with dose up to the amorphous threshold. In GaAs the increase in these quantities is neither linear nor monotonic with dose. At a moderate damage level the GaAs crystal undergoes a transition from elastic to plastic behavior. This transition is accompanied by the creation of extended defects, which are not detected in Si or Ge
Projectile Excitations in Reactions
It has recently been proven from measurements of the spin-transfer
coefficients and that there is a small but non-vanishing
component , in the inclusive reaction
cross section . It is shown that the dominant part of the measured
can be explained in terms of the projectile excitation
mechanism. An estimate is further made of contributions to from
s-wave rescattering process. It is found that s-wave rescattering contribution
is much smaller than the contribution coming from projectile
excitation mechanism. The addition of s-wave rescattering contribution to the
dominant part, however, improves the fit to the data.Comment: 9 pages, Revtex, figures can be obtained upon reques
Schwarzschild Atmospheric Processes: A Classical Path to the Quantum
We develop some classical descriptions for processes in the Schwarzschild
string atmosphere. These processes suggest relationships between macroscopic
and microscopic scales. The classical descriptions developed in this essay
highlight the fundamental quantum nature of the Schwarzschild atmospheric
processes.Comment: to appear in Gen. Rel. Gra
Dimension in a Radiative Stellar Atmosphere
Dimensional scales are examined in an extended 3+1 Vaidya atmosphere
surrounding a Schwarzschild source. At one scale, the Vaidya null fluid
vanishes and the spacetime contains only a single spherical 2-surface. Both of
these behaviors can be addressed by including higher dimensions in the
spacetime metric.Comment: to appear in Gen. Rel. Gra
Noise Effects on the Complex Patterns of Abnormal Heartbeats
Patients at high risk for sudden death often exhibit complex heart rhythms in
which abnormal heartbeats are interspersed with normal heartbeats. We analyze
such a complex rhythm in a single patient over a 12-hour period and show that
the rhythm can be described by a theoretical model consisting of two
interacting oscillators with stochastic elements. By varying the magnitude of
the noise, we show that for an intermediate level of noise, the model gives
best agreement with key statistical features of the dynamics.Comment: 4 pages, 4 figures, RevTe
Fractal Scales in a Schwarzschild Atmosphere
Recently, Glass and Krisch have extended the Vaidya radiating metric to
include both a radiation fluid and a string fluid [1999 Class. Quantum Grav.
vol 16, 1175]. Mass diffusion in the extended Schwarzschild atmosphere was
studied. The continuous solutions of classical diffusive transport are believed
to describe the envelope of underlying fractal behavior. In this work we
examine the classical picture at scales on which fractal behavior might be
evident.Comment: to appear in Class. Quantum Gra
Icebreaker-3 Drill Integration and Testing at Two Mars-Analog Sites
A decade of evolutionary development of integrated automated drilling and sample handling at analog sites and in test chambers has made it possible to go 1 meter through hard rocks and ice layers on Mars. The latest Icebreaker-3 drill has been field tested in 2014 at the Haughton Crater Marsanalog site in the Arctic and in 2015 with a Mars lander mockup in Rio Tinto, Spain, (with sample transfer arm and with a prototype life-detection instrument). Tests in Rio Tinto in 2015 successfully demonstrated that the drill sample (cuttings) was handed-off from the drill to the sample transfer arm and thence to the on-deck instrument inlet where it was taken in and analyzed ("dirt-to-data")
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