Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae. VIII: The Eighth Year (2015-2016)

Continuing the project described by Kato et al. (2009, arXiv:0905.1757), we collected times of superhump maxima for 128 SU UMa-type dwarf novae observed mainly during the 2015-2016 season and characterized these objects. The data have improved the distribution of orbital periods, the relation between the orbital period and the variation of superhumps, the relation between period variations and the rebrightening type in WZ Sge-type objects. Coupled with new measurements of mass ratios using growing stages of superhumps, we now have a clearer and statistically greatly improved evolutionary path near the terminal stage of evolution of cataclysmic variables. Three objects (V452 Cas, KK Tel, ASASSN-15cl) appear to have slowly growing superhumps, which is proposed to reflect the slow growth of the 3:1 resonance near the stability border. ASASSN-15sl, ASASSN-15ux, SDSS J074859.55+312512.6 and CRTS J200331.3-284941 are newly identified eclipsing SU UMa-type (or WZ Sge-type) dwarf novae. ASASSN-15cy has a short (~0.050 d) superhump period and appears to belong to EI Psc-type objects with compact secondaries having an evolved core. ASASSN-15gn, ASASSN-15hn, ASASSN-15kh and ASASSN-16bu are candidate period bouncers with superhump periods longer than 0.06 d. We have newly obtained superhump periods for 79 objects and 13 orbital periods, including periods from early superhumps. In order that the future observations will be more astrophysically beneficial and rewarding to observers, we propose guidelines how to organize observations of various superoutbursts.Comment: 123 pages, 162 figures, 119 tables, accepted for publication in PASJ (including supplementary information

Phenotypical and Functional Characteristics of Human Regulatory T Cells during Ex Vivo Maturation from CD4+ T Lymphocytes

Regulatory T cells (Tregs) participate in the negative regulation of inflammatory reactions by suppressing effector cells. In a number of autoimmune disorders, the suppressive function and/or the number of Tregs is compromised. The lack of active functioning Tregs can be restored with adoptive transfer of expanded ex vivo autologous Tregs. In our study, we traced the differentiation and maturation of Tregs CD4+CD25+FoxP3+CD127low over 7 days of cultivation from initial CD4+ T cells under ex vivo conditions. The resulting ex vivo expanded cell population (eTregs) demonstrated the immune profile of Tregs with an increased capacity to suppress the proliferation of target effector cells. The expression of the FoxP3 gene was upregulated within the time of expansion and was associated with gradual demethylation in the promotor region of the T cell-specific demethylation region. Real-time RT-PCR analysis revealed changes in the expression profile of genes involved in cell cycle regulation. In addition to FOXP3, the cells displayed elevated mRNA levels of Ikaros zinc finger transcription factors and the main telomerase catalytic subunit hTERT. Alternative splicing of FoxP3, hTERT and IKZF family members was demonstrated to be involved in eTreg maturation. Our data indicate that expanded ex vivo eTregs develop a Treg-specific phenotype and functional suppressive activity. We suggest that eTregs are not just expanded but transformed cells with enhanced capacities of immune suppression. Our findings may influence further development of cell immunosuppressive therapy based on regulatory T cells

Superoutburst of WZSge-type dwarf nova below the period minimum: ASASSN-15po

arXiv:1610.04941v1We report on a superoutburst of a WZ Sge-type dwarf nova (DN), ASASSN-15po. The light curve showed the main superoutburst and multiple rebrightenings. In this outburst, we observed early superhumps and growing (stage A) superhumps with periods of 0.050454(2) and 0.051809(13) d, respectively. We estimated that the mass ratio of secondary to primary (q) is 0.0699(8) by using P and a superhump period PSH of stage A. ASASSN-15po [P ∼ 72.6 min] is the first DN with an orbital period between 67-76 min. Although the theoretical predicted period minimum P of hydrogen-rich cataclysmic variables (CVs) is about 65-70 min, the observational cut-off of the orbital period distribution at 80 min implies that the period minimum is about 82min, and the value is widely accepted. We suggest the following four possibilities: the object is (1) a theoretical period minimum object, (2) a binary with a evolved secondary, (3) a binary with a metal-poor (Popullation II) seconday, or (4) a binary which was born with a brown-dwarf donor below the period minimum.This work was supported by a Grant-in-Aid “Initiative for High- Dimensional Data-Driven Science through Deepening of Sparse Modeling” from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (25120007). It was also partially supported by grants RFBR No. 15-02-06178, RFBR No. 14-02-0082 (S.S.), VEGA No. 2/0002/13 (S.S.) and RSF No. 14-12-00146 (P.G., for processing observation data from Slovak observatory).Peer Reviewe