937 research outputs found

    Developing mentorship in a resource-limited context: a qualitative research study of the experiences and perceptions of the makerere university student and faculty mentorship programme.

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    BACKGROUND: The aim of mentorship is to build the mentees capacity, enhance their skills and improve their ability to produce desired outcomes. However, the mentoring relationship is vulnerable to a number of challenges that may undermine its effectiveness and sustainability. We aimed to explore the experiences and perceptions of student and junior faculty mentees and senior faculty mentors at the Makerere University College of Health Sciences and identify the key factors defined by mentees and mentors as necessary for a successful mentorship program. METHODS: A qualitative design involving focus group discussions (FGDs) and key informant interviews (KII) was used. A total of eight KII and four FGDs were conducted, audio recorded and transcribed verbatim. Open coding of the transcripts was performed, and major themes were identified through multiple readings based on thematic analysis. RESULTS: Six key themes were shared by the mentees and mentors including: 1) defining the role of the mentor; 2) desired characteristics of a mentor and a mentoring relationship, with an emphasis on mutual trust and respect; 3) overlapping roles of mentors and supervisors; 4) issues with the process for identifying mentors, including the benefits and drawbacks of the mentee selecting mentor vs. being assigned a mentor; 5) current barriers to mentoring, including lack of knowledge about current program, lack of formal structure, uncertainly about who should initiate relationship, and unclear roles and expectations and 6) recommendations for the future development of mentoring programme, including the need for a formalized programme, and training adapted to the local context. CONCLUSIONS: The mentees and mentors described the role of the mentor and desired characteristics of mentors and a mentoring relationship similarly. Most concerns about mentoring occurred when current mentoring programmes and practices were not well aligned with these desired characteristics. Recommendations for future development of mentoring included greater formalization of mentoring with mentoring programmes based on shared expectations and adapted to the local context

    Methane emissions from forested closed landfill sites: Variations between tree species and landfill management practices

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    Trees in natural and managed environments can act as conduits for the transportation of methane (CH4) from below ground to the atmosphere, bypassing oxidation in aerobic surface soils. Tree stem emissions from landfill sites exhibit large temporal and spatial variability in temperate environments and can account for approximately 40% of the total surface CH4 flux. Emission variability was further investigated in this study by measuring CH4 and CO2 fluxes from landfill sites with different management strategies and varying tree species over a 7-month period. Stem and soil measurements were obtained using flux chambers and an off-axis integrated cavity output spectroscopy analyser. Analysis showed average stem and soil CH emissions varied significantly (p4 fluxes from sites with no clay cap but gas extraction, clay cap and gas extraction, and no clay cap and no gas extraction were 1.4 ± 0.4 μg m-2 h-1, 47.2 ± 19.0 μg m-2 h-1, and 111.9 ± 165.1 μg m-2 h-1, respectively. There was no difference in stem CH4 fluxes between species at each site, suggesting environmental conditions (waterlogging) and site age had a greater influence on both stem and soil fluxes. These results highlight the importance of management practices, and the resultant environmental conditions, in determining CH4 emissions from historic landfill sites

    Comparison of two-dimensional strain analysis using vendor-independent and vendor-specific software in adult and pediatric patients

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    Introduction: Two-dimensional strain analysis is a powerful analysis modality, however, clinical utilization has been limited by variability between different analysis systems and operators. We compared strain in adults and children using vendor-specific and vendor-independent software to evaluate variability.Methods: One hundred and ten subjects (50/110 pediatric, 80/110 normal left ventricular function) had echocardiograms with a General Electric ultrasound scanner between September 2010 and January 2012. Left ventricular longitudinal strain was derived with EchoPAC (General Electric, v10.8.1), a vendor-specific software, and Velocity Vector Imaging (Siemens, v3.5), which is vendor-independent. Three independent readers analyzed all the echocardiograms yielding 330 datasets.Results: Mean left ventricular global longitudinal Lagrangian strain was -18.1 ± SD 4.4% for EchoPAC and -15.3 ± SD 4.1% for Velocity Vector Imaging. Velocity Vector Imaging yielded lower absolute global longitudinal Lagrangian strain by mean 2.9 (±SD 2.7, p Conclusion: Velocity Vector Imaging produces lower left ventricular longitudinal strain values versus EchoPAC for the same echo images. Both systems have similar inter-observer variability, Velocity Vector Imaging slightly higher intra-observer variability. A statistically significant change in global longitudinal Lagrangian strain occurs with changes >3-5 strain points on repeat measurements. Strain values between the systems are not interchangeable

    Bioengineering silicon quantum dot theranostics using a network analysis of metabolomic and proteomic data in cardiac ischemia

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    Metabolomic profiling is ideally suited for the analysis of cardiac metabolism in healthy and diseased states. Here, we show that systematic discovery of biomarkers of ischemic preconditioning using metabolomics can be translated to potential nanotheranostics. Thirty-three patients underwent percutaneous coronary intervention (PCI) after myocardial infarction. Blood was sampled from catheters in the coronary sinus, aorta and femoral vein before coronary occlusion and 20 minutes after one minute of coronary occlusion. Plasma was analysed using GC-MS metabolomics and iTRAQ LC-MS/MS proteomics. Proteins and metabolites were mapped into the Metacore network database (GeneGo, MI, USA) to establish functional relevance. Expression of 13 proteins was significantly different (p<0.05) as a result of PCI. Included amongst these was CD44, a cell surface marker of reperfusion injury. Thirty-eight metabolites were identified using a targeted approach. Using PCA, 42% of their variance was accounted for by 21 metabolites. Multiple metabolic pathways and potential biomarkers of cardiac ischemia, reperfusion and preconditioning were identified. CD44, a marker of reperfusion injury, and myristic acid, a potential preconditioning agent, were incorporated into a nanotheranostic that may be useful for cardiovascular applications. Integrating biomarker discovery techniques into rationally designed nanoconstructs may lead to improvements in disease-specific diagnosis and treatment

    Observation of the Dynamic Beta Effect at CESR with CLEO

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    Using the silicon strip detector of the CLEO experiment operating at the Cornell Electron-positron Storage Ring (CESR), we have observed that the horizontal size of the luminous region decreases in the presence of the beam-beam interaction from what is expected without the beam-beam interaction. The dependence on the bunch current agrees with the prediction of the dynamic beta effect. This is the first direct observation of the effect.Comment: 9 page uuencoded postscript file, postscritp file also available through http://w4.lns.cornell.edu/public/CLNS, submitted to Phys. Rev.

    Search for the Decay τ4pi3π+(π0)ντ\tau^{-}\to 4pi^{-}3\pi^{+}(\pi^{0})\nu_{\tau}

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    We have searched for the decay of the tau lepton into seven charged particles and zero or one pi0. The data used in the search were collected with the CLEO II detector at the Cornell Electron Storage Ring (CESR) and correspond to an integrated luminosity of 4.61 fb^(-1). No evidence for a signal is found. Assuming all the charged particles are pions, we set an upper limit on the branching fraction, B(tau- -> 4pi- 3pi+ (pi0) nu_tau) < 2.4 x 10^(-6) at the 90% confidence level. This limit represents a significant improvement over the previous limit.Comment: 9 page postscript file, postscript file also available through http://w4.lns.cornell.edu/public/CLN

    Study of 3-prong Hadronic τ\tau Decays with Charged Kaons

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    Using a sample of 4.7/fb integrated luminosity accumulated with the CLEO-II detector at the Cornell Electron Storage Ring (CESR), we have measured the branching fractions of the tau lepton into Kh+πντK^- h^+ \pi^- \nu_\tau and KK+πντK^- K^+ \pi^- \nu_\tau relative to hh+hντ;Kh+ππ0ντh^- h^+ h^- \nu_\tau; K^- h^+ \pi^- \pi^0\nu_\tau and KK+ππ0ντK^- K^+ \pi^- \pi^0\nu_\tau relative to hh+hπ0ντh^- h^+ h^- \pi^0 \nu_\tau. The relative branching fractions are: (5.16+-0.20+-0.50)*10210^{-2}, (1.52+-0.14+-0.29)*10210^{-2}, (2.54+-0.44+-0.39)*10210^{-2} and <0.0154<0.0154 at 95% C.L., respectively. Coupled with additional experimental information, we use our results to extract information on the structure of three-prong tau decays to charged kaons.Comment: 16 pages postscript file also available through http://w4.lns.cornell.edu/public/CLN

    Further Search for the Two-Photon Production of the Glueball Candidate fJ(2220)f_{J}(2220)

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    The CLEOII detector at the Cornell e+ e- storage ring CESR has been used to search for the two-photon production of the fJ(2220)f_J(2220) decaying into pi+ pi-. No evidence for a signal is found in data corresponding to an integrated luminosity of 4.77/fb and a 95% CL upper limit on ΓtwophotonBRpi+pi\Gamma_{two-photon} * BR{pi+ pi-} of 2.5 eV is set. If this result is combined with the BES Collaboration's measurement of fJ(2220)>pi+pif_J(2220) -> pi+ pi- in radiative J/ψJ/\psi decay, a 95% CL lower limit on the stickiness of the fJ(2220)f_J(2220) of 73 is obtained. If the recent CLEO result for \Gamma_{two-photon} * BR{\K_S K_S} is combined with the present result, the stickiness of the fJ(2220)f_J(2220) is found to be larger than 102 at the 95% CL. These results for the stickiness (the ratio of the probabilities for two-gluon coupling and two-photon coupling) provide further support for a substantial neutral parton content in the fJ(2220)f_J(2220).Comment: 8 pages, postscript file also available through http://w4.lns.cornell.edu/public/CLN
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