Nationale Forschungsdateninfrastruktur für die Ingenieurwissenschaften (NFDI4Ing)

NFDI4Ing ist ein 2017 gegründetes Konsortium mit dem Ziel, Wissenschaftler:innen aller Disziplinen zu ermöglichen, ingenieurwissenschaftliche Forschungsprozesse in ihrer Gesamtheit nachvollziehen oder reproduzieren zu können. Die Besonderheit an NFDI4Ing ist der Aufbau, welcher sich in drei Bereiche aufteilt. Die Archetypen, die an den methodischen Bedarfen ausgerichtet sind, die Community Cluster und die Base Services. NFDI4Ing erarbeitet technologische Methoden und Lösungen, bietet Aus- und Weiterbildungsprogramme und trägt zur Verbreitung des Forschungsdatenmanagements (FDM) in den Ingenieurwissenschaften bei

Game laboratory studies

Prof. Dr. Jens Schröter ist Herausgeber der Reihe und die Herausgeber der einzelnen Hefte sind renommierte Wissenschaftler und -innen aus dem In- und Ausland.Um die Analyse von Computerspielen aus produktionsästhetischer Perspektive zu erproben, lehnt sich der vorliegende Band an die Akteur-Netzwerk-Theorie (ANT) an. Mit ihr geht es ihm um die Frage nach den Aktanten des Game Design – etwa: Welche Hard- und Softwarekomponenten kommen wann und wofür zum Einsatz; wie und mittels welcher Medien notieren Level-Designer ihre Ideen, und wie werden die Aufzeichnungen später von Programmierern implementiert; und welche Rolle spielt eigentlich eine Action-Figur auf dem Schreibtisch eines Textur-Artists

Periodontitis and pulmonary function: a Mendelian randomization study

Objectives!#!Observational research suggests that periodontitis affects pulmonary function; however, observational studies are subject to confounding and reverse causation, making causal inference and the direction of these associations difficult. We used Mendelian randomization (MR) to assess the potential causal association between genetic liability to periodontitis and pulmonary function.!##!Materials and methods!#!We used six single-nucleotide polymorphisms (SNPs) associated with periodontitis (P < 5 × 10!##!Results!#!MR analysis suggested no effect of periodontitis on the ratio of forced expiratory volume in one second to lower forced vital capacity (standard deviation increment in outcome per doubling of the odds of the exposure (95% confidence interval) =  - 0.004 (- 0.028; 0.020)). Replication analysis using genetic instruments from two different GWAS and sensitivity analyses to address potential pleiotropy led to no substantial changes in estimates.!##!Conclusions!#!Collectively, these findings do not support a relationship between genetic liability for periodontitis and pulmonary function.!##!Clinical relevance!#!Periodontitis does not seem to be a risk factor for worsening of pulmonary function

From low-power to no-power: adaptive clocking for event-driven systems

Reduction of power consumption of digital systems is a major concern especially in modern smart sensor systems. These systems are often only activated on request and their power consumption is therefore dominated by the idle-mode. Power reduction mechanisms such as clock or power gating reduce the activity or leakage in the purely digital circuits. We propose a novel adaptive clocking scheme that optimizes the energy demand using a fine-grained oscillator control on cycle-level. To evaluate our new approach, we analytically analyze the power consumption of the regarded system in comparison with available methods. The power of our new adaptive clocking is shown in an integrated smart sensor for capacitive measurements working in a passive wireless sensor node. Using our methods, we show that the energy demand of the example system is reduced even in the case of continuous measurements that demand for a high activity in the digital circuitry

Design of quasi-synchronous finite state machines using a local on-demand clocking approach

Nowadays robust, energy-efficient multisensor microsystems often come with heavily restricted power budgets and the characteristic of remaining in certain states for a longer period of time. During this time frame there is no continuous clock signal required which gives the opportunity to suspend the clock until a new transition is requested. In this paper, we present a new topology for on-demand locally clocked finite state machines. The architecture combines a local adaptive clocking approach with synchronous and asynchronous components forming a quasi synchronous system. Using adaptive and local clocking comes with the advantages of reducing the power consumption while saving design effort when no global clock tree is needed. Combining synchronous and asynchronous components is beneficial compared to previous fully asynchronous approaches concerning the design restrictions. The developed topology is verified by the implementation and simulation of a temperature-ADC sensor system realized in a 180 nm process

A pragmatic workflow for research software engineering in computational science

University research groups in Computational Science and Engineering (CSE) generally lack dedicated funding and personnel for Research Software Engineering (RSE), which, combined with the pressure to maximize the number of scientific publications, shifts the focus away from sustainable research software development and reproducible results. The neglect of RSE in CSE at University research groups negatively impacts the scientific output: research data - including research software - related to a CSE publication cannot be found, reproduced, or re-used, different ideas are not combined easily into new ideas, and published methods must very often be re-implemented to be investigated further. This slows down CSE research significantly, resulting in considerable losses in time and, consequentially, public funding. We propose a RSE workflow for Computational Science and Engineering (CSE) that addresses these challenges, that improves the quality of research output in CSE. Our workflow applies established software engineering practices adapted for CSE: software testing, result visualization, and periodical cross-linking of software with reports/publications and data, timed by milestones in the scientific publication process. The workflow introduces minimal work overhead, crucial for university research groups, and delivers modular and tested software linked to publications whose results can easily be reproduced. We define research software quality from a perspective of a pragmatic researcher: the ability to quickly find the publication, data, and software related to a published research idea, quickly reproduce results, understand or re-use a CSE method, and finally extend the method with new research ideas

From Constraints to Tape-Out. Towards a Continuous AMS Design Flow

The effort in designing analog/mixed-signal (AMS) integrated circuits is characterized by the largely manual work involved in the design of analog cells and their integration into the overall circuit. This inequality in effort between analog and digital cells increases with the use of modern, more complex technology nodes. To mitigate this problem, this paper presents four methods to improve existing mixed-signal design flows:(1) automatic schematic generation from a system-level model,(2) flexible automatic analog layout generation, (3) constraint propagation and budget calculation for dependency resolution, and (4) verification of nonfunctional effects. The implementation of these steps results in a novel AMS design flow with a significantly higher degree of automation

FAIR research software development: A Research Software Engineering workflow

We present with hands-on examples a Research Software Engineering (RSE) workflow for developing research software in Computational Science and Engineering (CSE) in university research groups. Their members have backgrounds from different scientific disciplines and often no education in RSE. Research software development lasts many years, contrary to team members leaving regularly. Combining and re-using ideas and results from others is a fundamental principle of science. In CSE research software embodies research ideas. As CSE research advances, research software should grow sustainably over the years. To increase the sustainability of research software, our workflow simplifies the investigation and integration of research ideas, ensures reproducibility and new functionality does not impair existing one. These practices speed up research and increase the quality of scientific output. Our CSE-RSE workflow is simple, effective and largely ensures the FAIR principles.The workflow uses established practices and tools, pragmatically adapted for CSE research software: version-control, secondary-data standards, continuous integration and containerization

Malaria and asymptomatic parasitaemia in Gabonese infants under the age of 3 months

We determined the incidence of both malaria and asymptomatic parasitaemia in infants under the age of 3 months within the framework of a longitudinal cohort study in Lambaréné, Gabon, between December 2002 and July 2004. Of 878 infants who were included at birth, we identified malaria in three infants and, additionally, asymptomatic parasitaemia in six infants. The malaria incidence density was 1.1/1000 person-months or 0.1% of observations. Our findings underpin the notion that the incidence of malaria and parasitaemia in infants below the age of 3 months is very lo

Nationale Forschungsdateninfrastruktur für die Ingenieurwissenschaften (NFDI4Ing)

NFDI4Ing ist ein 2017 gegründetes Konsortium mit dem Ziel, Wissenschaftler:innen aller Disziplinen zu ermöglichen, ingenieurwissenschaftliche Forschungsprozesse in ihrer Gesamtheit nachvollziehen oder reproduzieren zu können. Die Besonderheit an NFDI4Ing ist der Aufbau, welcher sich in drei Bereiche aufteilt. Die Archetypen, die an den methodischen Bedarfen ausgerichtet sind, die Community Cluster und die Base Services. NFDI4Ing erarbeitet technologische Methoden und Lösungen, bietet Aus- und Weiterbildungsprogramme und trägt zur Verbreitung des Forschungsdatenmanagements (FDM) in den Ingenieurwissenschaften bei