Development of a wearable framework for body center of mass acceleration assessment in people with transfemoral amputation

The biomechanical study of the body center of mass (BCoM) may reveal crucial information about gait impairment in people with amputation (Al Abiad et al. 2020). The 3D kinetics of the BCoM are usua..

Investigating symmetry in amputee gait through the improved harmonic ratio: influence of the stride segmentation method

The quantification of gait symmetry is extremely important in several clinical contexts. Among the many indices used to describe gait symmetry, the Harmonic Ratio (HR), which is based on a stride-b..

A Cloud-based System to Protect Against Industrial Multi-risk Events☆

Abstract Industrial areas frequently present a high concentration of production operations which are source of anthropic risks. For this reason Smart Public Safety is receiving an increasing attention from industry, research and authorities. Moreover, due the consequences of global warming, these areas could be subject to risk events with increased probability with respect to the past. Information technologies enable an innovative approach towards safety management, which relies on the evolution of tools for environmental monitoring and citizens' interaction. This work presents the preliminary results of the Italian research project SIGMA - sensor Integrated System in cloud environment for the Advanced Multi-risk Management. The proposed system includes a continuous monitoring of the different information sources, thus reducing human control as much as possible. At the same time, the communication system manages multiple data flows in a flexible way, adapting itself to different working scenarios, enabling smarter applications. SIGMA intends to acquire, integrate and compute heterogeneous data, coming from various sensor networks in order to provide useful insights for the monitoring, forecasting and management of risk situations through services provided to citizens and businesses, both public and private. Based on the integration of different interoperating components, the system is able to provide a complete emergency management framework through simulations/optimizations and heterogeneous data manipulation tools. The prototype solution is detailed by a use case application in an industrial area located in the region of Sicily, Italy. In particular, web based modular applications connected through SIGMA allow the monitoring of the industrial environment through data gathering from different sensor networks, such as outdoor sensors mounted in the surroundings of large industrial areas, and support of the design of the logistics network aimed at covering the industrial risks

Definition of an optimal model based on segments' contribution for the estimation of the acceleration of the center of mass in people with lower-limb amputation

In the context of rehabilitation of people with amputation, gait analysis provides information about gait alterations. In that perspective, the body center of mass (BCoM) trajectory, or its derivat..

Human Papilloma Virus-Associated Lips Verrucous Carcinoma in HIV-Infected Male.

Human papillomavirus (HPV) infection, widely known as the necessary cause of cervical cancer, has been established as a major etiologic factor for head and neck cancer (HNC). HIV-infected individuals are at higher risk of HPV-associated cancers than the general population. We describe a 45-year-old man with HIV and HPV coinfection, who presented progressively enlarging verrucous neoformations of the lips. The final diagnosis of verrucous carcinoma was delayed. Early detection of HPV lesions in oral mucosa and HPV screening activities could be important in improving the diagnostic sensitivity for the HIV-infected patients with oral cancer

Molecular mechanisms of euplotin C-induced apoptosis: involvement of mitochondrial dysfunction, oxidative stress and proteases

The metabolite euplotin C (EC), isolated from the marine ciliate Euplotes crassus, is a powerful cytotoxic and pro-apoptotic agent in tumour cell lines. For instance, EC induces the rapid depletion of ryanodine Ca2+ stores, the release of cytochrome c from the mitochondria, and the activation of caspase-3, leading to apoptosis. The purpose of this study was to gain further insight into the mechanisms of EC-induced apoptosis in rat pheochromocytoma PC12 cells. We found that EC increases Bax/Bcl-2 ratio and that Bax is responsible of the EC-induced dissipation of the mitochondrial membrane potential (Δψm). In addition, EC induces the generation of reactive oxygene species (ROS) without involvement of p53. The inhibition of ROS generation prevents, at least in part, the pro-apoptotic effects of EC as well as the effects of EC on Bax, Δψm and intracellular free Ca2+, indicating a cross-talk between different pathways. However, definition of the effector cascade turns out to be more complex than expected and caspase-independent mechanisms, acting in parallel with caspases, should also be considered. Among them, EC increases the expression/activity of calpains downstream of ROS generation, although calpains seem to exert protective effects.L'articolo è disponibile sul sito dell'editore http://www.springerlink.co

Perfusion-CT monitoring of cryo-ablated renal cells tumors

<p>Abstract</p> <p>Background</p> <p>No single and thoroughly validated imaging method in monitoring of cryoablated renal cell carcinoma (RCC) is available. The purpose of our study was to determine the feasibility of dynamic contrast-enhanced perfusion CT (pCT) in evaluating the hemodynamic response of RCC.</p> <p>Methods</p> <p>15 patients (14 male, 1 female; age range, 43-81 years; mean age, 62 years) with cryoablated RCC via a transperitoneal approach, underwent to pCT 6-8 months after cryo-therapy. pCT was performed for 65 seconds after intravenous injection of contrast medium (80 mL, 370 mg iodine per millilitre, 4 mL/sec). Perfusion parameters (Time/Density curve; Blood flow, BF; Blood Volume, BV; Mean Transit Time, MTT; Permeability-Surface Area Product, PS) were sampled in the cryoablated tumor area and in ipsilateral renal cortex using deconvolution-based method. A tumor was considered to be not responsive to treatment by CT evidence of pathological contrast enhancement in the cryoablated area or renal mass persistence compared with the preoperative CT control. Written informed consent was obtained from all participants before the study.</p> <p>Results</p> <p>After cryotherapy, successfully ablated tumor (n = 13) showed decrease in BV (5,39 +/- 1,28 mL/100 g), BF (69,92 +/- 20,12 mL/100 g/min) and PS (16,66 +/- 5,67 mL/100 g/min) value and increased value of MTT (25,35 +/- 4,3 sec) compared with those of normal renal cortex (BV: 117,86 +/- 31,87 mL/100 g/min; BF: 392,39 +/- 117,32 mL/100 g/min; MTT: 18,02 +/- 3,6 sec; PS: 81,68 +/- 22,75 mL/100 g/min). In one patient, assessment of perfusion parameters was not feasible for breathing artifacts. One tumor showed poor response to treatment by the evidence of nodular contrast enhancement in the region encompassing the original lesion. Two typical enhancement patterns were obtained comparing the Time-Density curves of responsive and not responsive ablated tumors.</p> <p>Conclusion</p> <p>Perfusion CT seems to be a feasible and promising technique in monitoring the effects of cryoablation therapy.</p

Seasonal thaws under mid-to-low pressure atmospheres on Early Mars

Despite decades of scientific research on the subject, the climate of the first 1.5 Gyr of Mars history has not been fully understood yet. Especially challenging is the need to reconcile the presence of liquid water for extended periods of time on the martian surface with the comparatively low insolation received by the planet, a problem which is known as the Faint Young Sun (FYS) Paradox. In this paper we use ESTM, a latitudinal energy balance model with enhanced prescriptions for meridional heat diffusion, and the radiative transfer code EOS to investigate how seasonal variations of temperature can give rise to local conditions which are conductive to liquid water runoffs. We include the effects of the martian dichotomy, a northern ocean with either 150 or 550 m of Global Equivalent Layer (GEL) and simplified CO$_2$ or H$_2$O clouds. We find that 1.3-to-2.0 bar CO$_2$-dominated atmospheres can produce seasonal thaws due to inefficient heat redistribution, provided that the eccentricity and the obliquity of the planet are sufficiently different from zero. We also studied the impact of different values for the argument of perihelion. When local favorable conditions exist, they nearly always persist for $>15\%$ of the martian year. These results are obtained without the need for additional greenhouse gases (e.g. H$_2$, CH$_4$) or transient heat-injecting phenomena (e.g. asteroid impacts, volcanic eruptions). Moderate amounts (0.1 to 1\%) of CH$_4$ significantly widens the parameter space region in which seasonal thaws are possible.Comment: Second and final version, 27 pages, 10 figures, accepted for publication in Ap

Estimation of 3D Body Center of Mass Acceleration and Instantaneous Velocity from a Wearable Inertial Sensor Network in Transfemoral Amputee Gait: A Case Study

The analysis of the body center of mass (BCoM) 3D kinematics provides insights on crucial aspects of locomotion, especially in populations with gait impairment such as people with amputation. In this paper, a wearable framework based on the use of different magneto-inertial measurement unit (MIMU) networks is proposed to obtain both BCoM acceleration and velocity. The proposed framework was validated as a proof of concept in one transfemoral amputee against data from force plates (acceleration) and an optoelectronic system (acceleration and velocity). The impact in terms of estimation accuracy when using a sensor network rather than a single MIMU at trunk level was also investigated. The estimated velocity and acceleration reached a strong agreement (ρ > 0.89) and good accuracy compared to reference data (normalized root mean square error (NRMSE) 0.89, NRMSE ≤ 14.0% in the mediolateral direction). Conversely, only the vertical component of the BCoM kinematics was accurately captured when considering a single MIMU. These results suggest that inertial sensor networks may represent a valid alternative to laboratory-based instruments for 3D BCoM kinematics quantification in lower-limb amputees.Don de la Fédération des Amputés de Guerre de France auprès de l'INI/CERH (contrat doctoral) Bourse mobilité cotutelle Université Franco-Italienne, VINCI C2-88