Pairing of Cooper pairs in a Josephson junction network containing an impurity

We show how to induce pairing of Cooper pairs (and, thus, $4e$ superconductivity) as a result of local embedding of a quantum impurity in a Josephson network fabricable with conventional junctions. We find that a boundary double Sine-Gordon model provides an accurate description of the dc Josephson current patterns, as well as of the stable phases accessible to the network. We point out that tunneling of pairs of Cooper pairs is robust against quantum fluctuations, as a consequence of the time reversal invariance, arising when the central region of the network is pierced by a dimensionless magnetic flux $\phi = \pi$. We find that, for $\phi = \pi$, a stable attractive finite coupling fixed point emerges and point out its relevance for engineering a two level quantum system with enhanced coherence.Comment: 5 Pages, 5 Figures. Small modifications, ref.[11] added. To appear in EP

Investigation of the potentialities of photochemical laser systems. Part I - Survey and analysis Final report, 1 Feb. 1966 - 31 Jan. 1967

Photodissociative laser systems used to convert solar radiation to monochromatic coherent emission - excitation mechanisms, spectroscopy of gases absorbing light, and chemical processe

Coplanar back contacts for thin silicon solar cells

The type of coplanar back contact solar cell described was constructed with interdigitated n(+) and p(+) type regions on the back of the cell, such that both contacts are made on the back with no metallization grid on the front. This cell construction has several potential advantages over conventional cells for space use namely, convenience of interconnects, lower operating temperatures and higher efficiency due to the elimination of grid shadowing. However, the processing is more complex, and the cell is inherently more radiation sensitive. The latter problem can be reduced substantially by making the cells very thin (approximately 50 micrometers). Two types of interdigitated back contact cells are possible, the types being dependent on the character of the front surface. The front surface field cell has a front surface region that is of the same conductivity type as the bulk but is more heavily doped. This creates an electric field at the surface which repels the minority carriers. The tandem junction cell has a front surface region of a conductivity type that is opposite to that of the bulk. The junction thus created floats to open circuit voltage on illumination and injects carriers into the bulk which then can be collected at the rear junction. For space use, the front surface field cell is potentially more radiation resistant than the tandem junction cell because the flow of minority carriers (electrons) into the bulk will be less sensitive to the production of recombination centers, particularly in the space charge region at the front surface

MELK expression correlates with tumor mitotic activity but is not required for cancer growth

The Maternal Embryonic Leucine Zipper Kinase (MELK) has been identified as a promising therapeutic target in multiple cancer types. MELK over-expression is associated with aggressive disease, and MELK has been implicated in numerous cancer-related processes, including chemotherapy resistance, stem cell renewal, and tumor growth. Previously, we established that triple-negative breast cancer cell lines harboring CRISPR/Cas9-induced null mutations in MELK proliferate at wild-type levels in vitro (Lin et al., 2017). Here, we generate several additional knockout clones of MELK and demonstrate that across cancer types, cells lacking MELK exhibit wild-type growth in vitro, under environmental stress, in the presence of cytotoxic chemotherapies, and in vivo. By combining our MELK-knockout clones with a recently described, highly specific MELK inhibitor, we further demonstrate that the acute inhibition of MELK results in no specific anti-proliferative phenotype. Analysis of gene expression data from cohorts of cancer patients identifies MELK expression as a correlate of tumor mitotic activity, explaining its association with poor clinical prognosis. In total, our results demonstrate the power of CRISPR/Cas9-based genetic approaches to investigate cancer drug targets, and call into question the rationale for treating patients with anti-MELK monotherapies

Josephson current through a long quantum wire

The dc Josephson current through a long SNS junction receives contributions from both Andreev bound states localized in the normal region as well as from scattering states incoming from the superconducting leads. We show that in the limit of a long junction, this current, at low temperatures, can be expressed entirely in terms of properties of the Andreev bound states at the Fermi energy: the normal and Andreev reflection amplitudes at the left-hand and at the right-hand S-N interface. This has important implications for treating interactions in such systems.Comment: 25 pages, 5 figure

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials

The Maternal Embryonic Leucine Zipper Kinase (MELK) has been reported to be a genetic dependency in several cancer types. MELK RNAi and small-molecule inhibitors of MELK block the proliferation of various cancer cell lines, and MELK knockdown has been described as particularly effective against the highly-aggressive basal/triple-negative subtype of breast cancer. Based on these preclinical results, the MELK inhibitor OTS167 is currently being tested as a novel chemotherapy agent in several clinical trials. Here, we report that mutagenizing MELK with CRISPR/Cas9 has no effect on the fitness of basal breast cancer cell lines or cell lines from six other cancer types. Cells that harbor null mutations in MELK exhibit wild-type doubling times, cytokinesis, and anchorage-independent growth. Furthermore, MELK-knockout lines remain sensitive to OTS167, suggesting that this drug blocks cell division through an off-target mechanism. In total, our results undermine the rationale for a series of current clinical trials and provide an experimental approach for the use of CRISPR/Cas9 in preclinical target validation that can be broadly applied

Investigation of the potentialities of photochemical laser systems. Part 2 - Preliminary experimental studies Final report, 1 Feb. 1966 - 31 Jan. 1967

Potential of photodissociative laser system for converting solar radiation to monochromatic coherent emissio

Dissipative quantum chaos: transition from wave packet collapse to explosion

Using the quantum trajectories approach we study the quantum dynamics of a dissipative chaotic system described by the Zaslavsky map. For strong dissipation the quantum wave function in the phase space collapses onto a compact packet which follows classical chaotic dynamics and whose area is proportional to the Planck constant. At weak dissipation the exponential instability of quantum dynamics on the Ehrenfest time scale dominates and leads to wave packet explosion. The transition from collapse to explosion takes place when the dissipation time scale exceeds the Ehrenfest time. For integrable nonlinear dynamics the explosion practically disappears leaving place to collapse.Comment: 4 pages, 4 figure