34 research outputs found
Unique opportunities for NMR methods in structural genomics
This Perspective, arising from a workshop held in July 2008 in Buffalo NY, provides an overview of the role NMR has played in the United States Protein Structure Initiative (PSI), and a vision of how NMR will contribute to the forthcoming PSI-Biology program. NMR has contributed in key ways to structure production by the PSI, and new methods have been developed which are impacting the broader protein NMR community
Unique opportunities for NMR methods in structural genomics
This Perspective, arising from a workshop held in July 2008 in Buffalo NY, provides an overview of the role NMR has played in the United States Protein Structure Initiative (PSI), and a vision of how NMR will contribute to the forthcoming PSI-Biology program. NMR has contributed in key ways to structure production by the PSI, and new methods have been developed which are impacting the broader protein NMR community
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Hanford 100N Area Apatite Emplacement: Laboratory Results of Ca-Citrate-PO4 Solution Injection and Sr-90 Immobilization in 100N Sediments
This report summarizes laboratory scale studies investigating the remediation of Sr-90 by Ca-citrate-PO4 solution injection/infiltration to support field injection activities in the Hanford 100N area. This study is focused on experimentally testing whether this remediation technology can be effective under field scale conditions to mitigate Sr-90 migration 100N area sediments into the Columbia River. Sr-90 is found primarily adsorbed to sediments by ion exchange (99% adsorbed, < 1% in groundwater) in the upper portion of the unconfined aquifer and lower vadose zone. Although primarily adsorbed, Sr-90 is still considered a high mobility risk as it is mobilized by seasonal river stage increases and by plumes of higher ionic strength relative to groundwater. This remediation technology relies upon the Ca-citrate-PO4 solution forming apatite precipitate [Ca6(PO4)10(OH)2], which incorporates some Sr-90 during initial precipitation and additionally slowly incorporates Sr-90 by solid phase substitution for Ca. Sr substitution occurs because Sr-apatite is thermodynamically more stable than Ca-apatite. Once the Sr-90 is in the apatite structure, Sr-90 will decay to Y-90 (29.1 y half-life) then Zr-90 (64.1 h half-life) without the potential for migration into the Columbia River. For this technology to be effective, sufficient apatite needs to be emplaced in sediments to incorporate Sr and Sr-90 for 300 years (~10 half-lives of Sr-90), and the rate of incorporation needs to exceed the natural groundwater flux rate of Sr in the 100N area. A primary objective of this study is to supply an injection sequence to deliver sufficient apatite into subsurface sediments that minimizes initial mobility of Sr-90, which occurs because the injection solution has a higher ionic strength compared to groundwater. This can be accomplished by sequential injections of low, then high concentration injection of Ca-citrate-PO4 solutions. Assessment of low concentration Ca-citrate-PO4, citrate-PO4, and PO4 solutions show greater Sr and Sr-90 incorporation during initial precipitation and less initial mobilization with solutions with low Ca2+ concentration. While all solutions showed nearly the same Sr uptake into apatite (14 to 17% by 2 weeks, 21% to 30% by 5 weeks), the incorporation efficiency (i.e., mM Sr incorporated per mM PO4 injected) was higher for solutions containing citrate. The Sr incorporation rate into apatite during initial precipitation (by 1 month) averaged 4.64 ± 1.9 x 10-4 h-1 (half-life 1500 ± 430 h, 8.85 x 10-7 mg Sr/day/mg apatite). The injection solution used in field injections #3 to #18 (10 mM PO4, 1 mM Ca, 2.5 mM citrate), which is deficient in Ca (a total of 16.7 mM needed to form apatite with 10 mM of PO4), resulted in the initial Sr and Ca peak (24 h) at 4.7x groundwater. By 30 days, the aqueous Sr concentration was 0.28x groundwater and Ca 0.43x groundwater, as both Sr and Ca are used to form initial apatite precipitates. Reactive transport simulation of the complex ion exchange, biodegradation, and precipitation processes showed that the initial Sr groundwater increase mobilized only 1.5% of the Sr mass in sediments. Citrate biodegradation, a necessary step in Ca-citrate-PO4 solutions forming apatite, had an average half-life of 50 h (at aquifer sediment/water ratio and temperature), and decreased an order of magnitude with sediment depth as the microbial biomass decreased five orders of magnitude. The rate of citrate biodegradation was relatively invariant with biomass and water saturation (50% to 100%, for vadose zone infiltration) possibly due to significant microbial injection using river water and subsurface microbial mobilization
Architectures for Multinode Superconducting Quantum Computers
Many proposals to scale quantum technology rely on modular or distributed
designs where individual quantum processors, called nodes, are linked together
to form one large multinode quantum computer (MNQC). One scalable method to
construct an MNQC is using superconducting quantum systems with optical
interconnects. However, a limiting factor of these machines will be internode
gates, which may be two to three orders of magnitude noisier and slower than
local operations. Surmounting the limitations of internode gates will require a
range of techniques, including improvements in entanglement generation, the use
of entanglement distillation, and optimized software and compilers, and it
remains unclear how improvements to these components interact to affect overall
system performance, what performance from each is required, or even how to
quantify the performance of each. In this paper, we employ a `co-design'
inspired approach to quantify overall MNQC performance in terms of hardware
models of internode links, entanglement distillation, and local architecture.
In the case of superconducting MNQCs with microwave-to-optical links, we
uncover a tradeoff between entanglement generation and distillation that
threatens to degrade performance. We show how to navigate this tradeoff, lay
out how compilers should optimize between local and internode gates, and
discuss when noisy quantum links have an advantage over purely classical links.
Using these results, we introduce a roadmap for the realization of early MNQCs
which illustrates potential improvements to the hardware and software of MNQCs
and outlines criteria for evaluating the landscape, from progress in
entanglement generation and quantum memory to dedicated algorithms such as
distributed quantum phase estimation. While we focus on superconducting devices
with optical interconnects, our approach is general across MNQC
implementations.Comment: 23 pages, white pape
Building a Quantum Engineering Undergraduate Program
Contribution: A roadmap is provided for building a quantum engineering education program to satisfy U.S. national and international workforce needs.
Background: The rapidly growing quantum information science and engineering (QISE) industry will require both quantum-aware and quantum-proficient engineers at the bachelor\u27s level.
Research Question: What is the best way to provide a flexible framework that can be tailored for the full academic ecosystem?
Methodology: A workshop of 480 QISE researchers from across academia, government, industry, and national laboratories was convened to draw on best practices; representative authors developed this roadmap.
Findings: 1) For quantum-aware engineers, design of a first quantum engineering course, accessible to all STEM students, is described; 2) for the education and training of quantum-proficient engineers, both a quantum engineering minor accessible to all STEM majors, and a quantum track directly integrated into individual engineering majors are detailed, requiring only three to four newly developed courses complementing existing STEM classes; 3) a conceptual QISE course for implementation at any postsecondary institution, including community colleges and military schools, is delineated; 4) QISE presents extraordinary opportunities to work toward rectifying issues of inclusivity and equity that continue to be pervasive within engineering. A plan to do so is presented, as well as how quantum engineering education offers an excellent set of education research opportunities; and 5) a hands-on training plan on quantum hardware is outlined, a key component of any quantum engineering program, with a variety of technologies, including optics, atoms and ions, cryogenic and solid-state technologies, nanofabrication, and control and readout electronics
Building a Quantum Engineering Undergraduate Program
The rapidly growing quantum information science and engineering (QISE)
industry will require both quantum-aware and quantum-proficient engineers at
the bachelor's level. We provide a roadmap for building a quantum engineering
education program to satisfy this need. For quantum-aware engineers, we
describe how to design a first quantum engineering course accessible to all
STEM students. For the education and training of quantum-proficient engineers,
we detail both a quantum engineering minor accessible to all STEM majors, and a
quantum track directly integrated into individual engineering majors. We
propose that such programs typically require only three or four newly developed
courses that complement existing engineering and science classes available on
most larger campuses. We describe a conceptual quantum information science
course for implementation at any post-secondary institution, including
community colleges and military schools. QISE presents extraordinary
opportunities to work towards rectifying issues of inclusivity and equity that
continue to be pervasive within engineering. We present a plan to do so and
describe how quantum engineering education presents an excellent set of
education research opportunities. Finally, we outline a hands-on training plan
on quantum hardware, a key component of any quantum engineering program, with a
variety of technologies including optics, atoms and ions, cryogenic and
solid-state technologies, nanofabrication, and control and readout electronics.
Our recommendations provide a flexible framework that can be tailored for
academic institutions ranging from teaching and undergraduate-focused two- and
four-year colleges to research-intensive universities.Comment: 25 pages, 2 figure