Custo médio de produção de suínos para abate: anexo 24 - junho/86.

bitstream/item/59012/1/CUsersPiazzonDocuments109.pd

Semi-analytical approach for the Vaidya metric in double-null coordinates

We reexamine here a problem considered in detail before by Waugh and Lake: the solutions of spherically symmetric Einstein's equations with a radial flow of unpolarized radiation (the Vaidya metric) in double-null coordinates. This problem is known to be not analytically solvable, the only known explicit solutions correspond to the constant mass case (Schwarzschild solution in Kruskal-Szekeres form) and the linear and exponential mass functions originally discovered by Waugh and Lake. We present here a semi-analytical approach that can be used to discuss some qualitative and quantitative aspects of the Vaidya metric in double-null coordinates for generic mass functions. We present also a new analytical solution corresponding to $(1/v)$-mass function.Comment: 5 pages, 6 figure

Efeitos da calagem na produção e nodulação da Alfafa.

O nitrogênio é o macronutriente mais utilizado pelas plantas sendo constituintes de aminoácidos, proteínas e ácidos nucléicos. Na planta, a fixação biológica do nitrogênio (N) é o processo através do qual o N atmosférico é fixado em amônia pelas bactérias e disponibilizado para as mesmas. Este processo de simbiose ocorre preferencialmente entre plantas leguminosas e bactérias diazotróficas. O objetivo deste trabalho foi observar os efeitos da FBN em cultura de alfafa (Medicago sativa L), planta forrageira pertencente à família das Leguminosae, subfamília Papilonoideae, apresentando alta exigência nutricional e elevado teor nutritivo com 22 a 25% de proteína bruta. Para obter o seu máximo potencial de produção de forragem é necessário que o pH do solo esteja na faixa de 6,5 a 7,0, abaixo disto, sua produtividade é seriamente comprometida

Vinhaça como fonte de nutrição mineral e gesso para produção de alfafa.

A vinhaça é o resíduo gerado durante a produção do álcool e açúcar possuindo grandes quantidades de matéria orgânica e alta concentração de potássio (K), cálcio (Ca) e magnésio (Mg), nutrientes estes, necessários ao desenvolvimento das plantas. Por possuir um alto valor como fertilizante, proporciona a redução deste resíduo na natureza devido ao seu reaproveitamento no campo

Peste suína clássica: custo de um surto.

bitstream/item/58655/1/CUsersPiazzonDocuments190.pd

Occlusal Interferences in Localised and Generalized Periodontitis

Značaj okuzijskih zapreka u razvoju i u terapiji parodontnih bolesti i poremećaja iznimno je kontroverzan. Još uvijek su u najstručnijim krugovima znanstvenika aktualne rasprave o povezanosti zapreka i okluzijske traume i o njihovoj ulozi u parodontnoj bolesti. Svrha rada bila je istražiti postoji li statistički znatna razlika u pojavnosti okluzijskih zapreka ( na radnoj i balansnoj strani) između skupine pacijenata s lokaliziranim parodontitisom i skupine pacijenata s generaliziranim parodontitisom. Ispitanici su bili pacijenti s parodontnom bolesti, koji su klasificirani prema Extent and Severity Indexu (ESI) na ispitivanu skupinu lokaliziranih parodontitisa i ispitivanu skupinu generaliziranih parodontitisa. Kretnje na laterotruzijskoj strani/kontakti u interkaninom području tijekom protruzijske kretnje bilježene su plavim artikulacijskim papirom debljine 12µ, a kontakti na mediotruzijskoj strani/kontakti u lateralnim područjima tijekom protruzijske kretnje bilježeni su crvenim artikulacijskim papirom debljine 12µ. U obje ispitivane skupine 45,12% ispitanika imalo je zapreke na radnoj strani, a 48,78% ispitanika imalo je zapreke na balansnoj strani. U skupini lokaliziranoga parodontitisa 33,33% ispitanika imalo je zapreke na radnoj strani, a 50,81% ispitanika imalo ih je u skupini generaliziranoga parodontitisa. Zapreke na balansnoj strani postojale su u 52,38% ipitanika u skupini lokaliziranoga parodontitisa, a 47,54% ispitanika imalo ih je u skupini generaliziranoga parodontitisa. Hi-kvadrat testom utvrđeno je da ne postoji statistički znatna razlika između pojavnosti okluzijskih zapreka u skupini ispitanika s lokaliziranim parodontitisom u usporedbi sa skupinom ispitanika s generaliziranim parodontitisom. Iako nema statistički znatne razlike, postoji tendencija razlike u frekvencijama (p = 0,054) te je vidljivo da u skupini ispitanika s generaliziranim parodontitisom postoji više slučajeva bez zapreka na balansnoj strani (52,45%) u odnosu prema skupini ispitanika s lokaliziranim parodontitisom (47,61%). Rezultati ovog istraživanja pokazuju da ne postoji statistički znatna razlika u pojavnosti okluzijskih zapreka u skupini ispitanika s lokaliziranim parodontitisom i u skupini ispitanika s generaliziranim parodontitisom.The significance of occlusal interference in the development and therapy of periodontal disease is very controversial. There are still very vivid discussions going on between experts whether or not interferences cause occlusal trauma, and wath is its role in periodontal disease. The aim of the study was to investigate whether there i statistically significant difference in the manifestation of occlusal interferences (working side and balancing side) among a group of patients sufferig from localised periodontitis and a group of patients with generalized periodontitis. Examinees were patients with periodontal disease, classified according to Extent and Severity Index (ESI) into a group with localised periodontitis and a group with generalized peiodontitis. Movements on the laterotrusion side/contacts in the intercanine segment in protrusion were marked with blue articulation paper 12µ thick, while contacts on the mediotrusion side/contacts in lateral segments during protrusion were marked with red articulation paper (12µ thick). Of al patients, there were 45.12% with working side interferences, and 48.78% with balancing side interferences in both examined groups. 33.33% of the examinees in the group with localised periodontitis had working side interferences, and 50.81% of the examinees in the group with generalized periodontitis. Balancing side interferences were found in 52.38% of patients in the group with localised periodontitis, and 47.54% of patients in the group with generalized periodontitis. Chi-square test showed that there was statistically significant difference between manifestation of occlusal interferences in the group of patients with localised periodontitis compared to manifestation of articulation interferences in the group of patients with generalized periodontitis (chi-square = 3.561; p = 0.313). Although there was no statistically significant difference, there was a tendency to difference in frequencies (p = 0.054), and it is shown that in the group of patients with generalized periodontitis there were more cases with no balancing side interferences on any side (52.45%), compared to the group of patients with localised periodontitis (47.61%). Results showed that there was no difference in manfestation of occlusal interferences in localised peiodontitis compared to generalized periodontitis

Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies

Simple Summary Human RAD52 is a non-essential DNA/RNA-binding protein thought to be involved in many DNA repair mechanisms. Initially regarded as having a major role only in error-prone backup DNA repair mechanisms, RAD52 has recently gained attention because its inhibition induces synthetic lethality in cancer cells with an inactivated homologous recombination pathway (for error-free double-strand-break repair). RAD52 is thus a potential target to overcome resistance and unwanted side effects. Unfortunately, researchers still lack detailed structural and mechanistic information on RAD52 and have identified only a limited number of inhibitors, none of which are in the preclinical phase. This review summarizes the current knowledge on RAD52, highlighting the potential of its inhibition. This review also discusses the critical gaps in knowledge and sets out future directions for effective campaigns to discover RAD52 inhibitors. In recent years, the RAD52 protein has been highlighted as a mediator of many DNA repair mechanisms. While RAD52 was initially considered to be a non-essential auxiliary factor, its inhibition has more recently been demonstrated to be synthetically lethal in cancer cells bearing mutations and inactivation of specific intracellular pathways, such as homologous recombination. RAD52 is now recognized as a novel and critical pharmacological target. In this review, we comprehensively describe the available structural and functional information on RAD52. The review highlights the pathways in which RAD52 is involved and the approaches to RAD52 inhibition. We discuss the multifaceted role of this protein, which has a complex, dynamic, and functional 3D superstructural arrangement. This complexity reinforces the need to further investigate and characterize RAD52 to solve a challenging mechanistic puzzle and pave the way for a robust drug discovery campaign