520 research outputs found
Recommended from our members
Microfungi of preservative treated Douglas-fir poles before and after fumigant treatment
See pd
Allegacion por don Antonio Bermudez de Nauacerrada y Chaues, gentilhombre de Boca de su Magestad, y Regidor perpetuo de Segovia y don Luis Giron de la Hoz y Chaves, clerigo de Epistola de Segovia con Don Iuan Antonio de la Loa, vezino de Segouia sobre el Patronato y Capellania que se intitula de los Bermudez fundada en Cuellar en que el señor Doct. Don Alonso Portillo y Cardos, Arcediano de Guadalaxara, Dignidad y Canonigo en la Santa Iglesia de esta Ciudad, con sumo desvelo y el acierto que estila, ha explanado Dubios y acordado de Oficio por motivos prudenciales, que los Abogados, escrivan en derecho para la mejor determinacion
Precede al tít.: [crismón] e "Initium sapientiae est timor domini"Al final del texto firma: "Licenc. Don Juan de Guevara"En v. de h. 2 consta 1710.Sign.: A-E>2<
Sequela del procés de Andilla [Manuscrito] : tercia parte : registre
DeterioradoTexto en latín, italiano, valenciano y castellanoSin enc.Pag. diversaadmtvo.0
β-Hydroxy-β-Methylbutyrate (HMB) Promotes Neurite Outgrowth in Neuro2a Cells
β-Hydroxy-β-methylbutyrate (HMB) has been shown to enhance cell survival, differentiation and protein turnover in muscle, mainly activating phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) and mitogen-activated protein kinases/ extracellular-signal-regulated kinases (MAPK/ERK) signaling pathways. Since these two pathways are related to neuronal survival and differentiation, in this study, we have investigated the neurotrophic effects of HMB in mouse neuroblastoma Neuro2a cells. In Neuro2a cells, HMB promotes differentiation to neurites independent from any effects on proliferation. These effects are mediated by activation of both the PI3K/Akt and the extracellular-signal-regulated kinases (ERK1/2) signaling as demonstrated by the use of specific inhibitors of these two pathways. As myocyte-enhancer factor 2 (MEF2) family of transcription factors are involved in neuronal survival and plasticity, the transcriptional activity and protein levels of MEF2 were also evaluated. HMB promoted MEF2-dependent transcriptional activity mediated by the activation of Akt and ERK1/2 pathways. Furthermore, HMB increases the expression of brain glucose transporters 1 (GLUT1) and 3 (GLUT3), and mTOR phosphorylation, which translates in a higher protein synthesis in Neuro2a cells. Furthermore, Torin1 and rapamycin effects on MEF2 transcriptional activity and HMB-dependent neurite outgrowth support that HMB acts through mTORC2. Together, these findings provide clear evidence to support an important role of HMB in neurite outgrowth.This project has been funded by Abbott Nutrition R&D
Search for Lorentz and CPT Violation Effects in Muon Spin Precession
The spin precession frequency of muons stored in the storage ring has
been analyzed for evidence of Lorentz and CPT violation. Two Lorentz and CPT
violation signatures were searched for: a nonzero
(=); and a sidereal variation of
. No significant effect is found, and the following
limits on the standard-model extension parameters are obtained: GeV; GeV; and the 95% confidence level limits
GeV and
GeV.Comment: 5 pages, 3 figures, submitted to Physical Review Letters, Modified to
answer the referees suggestion
An Improved Limit on the Muon Electric Dipole Moment
Three independent searches for an electric dipole moment (EDM) of the
positive and negative muons have been performed, using spin precession data
from the muon g-2 storage ring at Brookhaven National Laboratory. Details on
the experimental apparatus and the three analyses are presented. Since the
individual results on the positive and negative muon, as well as the combined
result, d=-0.1(0.9)E-19 e-cm, are all consistent with zero, we set a new muon
EDM limit, |d| < 1.9E-19 e-cm (95% C.L.). This represents a factor of 5
improvement over the previous best limit on the muon EDM.Comment: 19 pages, 15 figures, 7 table
Search for Lorentz and CPT Violation Effects in Muon Spin Precession
The spin precession frequency of muons stored in the storage ring has
been analyzed for evidence of Lorentz and CPT violation. Two Lorentz and CPT
violation signatures were searched for: a nonzero
(=); and a sidereal variation of
. No significant effect is found, and the following
limits on the standard-model extension parameters are obtained: GeV; GeV; and the 95% confidence level limits
GeV and
GeV.Comment: 5 pages, 3 figures, submitted to Physical Review Letters, Modified to
answer the referees suggestion
The Muon Anomalous Magnetic Moment and the Standard Model
The muon anomalous magnetic moment measurement, when compared with theory,
can be used to test many extensions to the standard model. The most recent
measurement made by the Brookhaven E821 Collaboration reduces the uncertainty
on the world average of a_mu to 0.7 ppm, comparable in precision to theory.
This paper describes the experiment and the current theoretical efforts to
establish a correct standard model reference value for the muon anomaly.Comment: Plenary Talk; PANIC'02 XVI Particles and Nuclear International
Conference, Osaka, Japan; Sept. 30 - Oct. 4, 2002; Report describes the
published 0.7 ppm result and updates the theory statu
- …