Itineraries of an Anthropologist. Studies in Honour of Massimo Raveri

This book is being dedicated to Massimo Raveri on the occasion of his retirement. It is designed to recreate the various thematic itineraries that he has traced and followed in his career. Each of the essays included represents a topic in which Prof. Raveri has shown great interest, paving the way for further studies. In offering these essays to him, his friends and colleagues are both bearing witness to his interest in such topics and contributing to their study. Contributions by former students of Prof. Raveri’s further show how these fields of study are being developed in his footsteps

See the winds. Practical dimensions of weather forecasting in a Japanese coastal community

The article examines how folk methodologies for weather prediction in- fluence small-scale agricultural and fishing activities of a Japanese coastal community. Specifically, the article addresses some anthropological questions on how local fishermen predict the weather by developing two different fore- casting practices: takayama, a practical weather observation technique that combines the observation of the clouds with a traditional nautical technique for orientation at sea and, okite, a model-based weather prognostication used to forecast long-term weather trends for the following year

Savoring authenticity: food consumption and nostalgia in Japan

The Japanese culinary tradition and contemporary food-related values are often characterized by an emotional and evocative tone that can be traced back to nostalgia, a global multidimensional phenomenon that blends cultural anxieties, sentimental values and sense of place. The desire to remember home through food consumption, as a valuable way of approaching the past, enables the construction or redefinition of ethnic identities, cultural boundaries and a sense of uniqueness. This paper offers some introductory reflections on present-day practices and affective aspects related to Japanese food culture from the point of view of their symbolic meaning in media narratives

Introduction

This volume is a Festschrift in honour of Massimo Raveri, Honorary Professor of Japanese Religions at the Department of Asian and North-African Studies at Ca’ Foscari University of Venice. This wide-ranging collection features essays that pay homage to his extensive academic interests and his interdisciplinary approach to the study of classical and contemporary Japanese religions. It is a tribute by friends and colleagues wishing to express their esteem and affection towards a scholar who, over the course of his long career, has shared many research experiences with them, in a spirit of unfailing support and collaboration

Small-scale Fisheries in Japan. Environmental and Socio-cultural Perspectives

This collection of essays brings together a range of various critical approaches, to provide an in-depth overview of the past and current status of small-scale fisheries in Japan. Covering different aspects of environmental, economic and cultural dimensions, the book attempts to map out some of the major themes relating to community-based fisheries-management systems, environmental sustainability, lottery systems for allocating fishing spots, fishing livelihoods, local knowledge, social vulnerability to environmental hazards, socioeconomic factors affecting small-scale fisheries development, history and nature of destructive fishing practices, women’s entrepreneurship in the seafood sector, traditional leadership systems, religious festivals, and power relationship between local communities and government agencies. The aim of this book is then to provide a comprehensive and multifaceted analysis of the cultural richness of this fishing sector, which still plays a key role in the broad academic debates focused on the potential small-scale fishery trajectories within the context of global scenarios

Surface-antigen expression profiling of B cell chronic lymphocytic leukemia: from the signature of specific disease subsets to the identification of markers with prognostic relevance

Studies of gene expression profiling have been successfully used for the identification of molecules to be employed as potential prognosticators. In analogy with gene expression profiling, we have recently proposed a novel method to identify the immunophenotypic signature of B-cell chronic lymphocytic leukemia subsets with different prognosis, named surface-antigen expression profiling. According to this approach, surface marker expression data can be analysed by data mining tools identical to those employed in gene expression profiling studies, including unsupervised and supervised algorithms, with the aim of identifying the immunophenotypic signature of B-cell chronic lymphocytic leukemia subsets with different prognosis. Here we provide an overview of the overall strategy employed for the development of such an "outcome class-predictor" based on surface-antigen expression signatures. In addition, we will also discuss how to transfer the obtained information into the routine clinical practice by providing a flow-chart indicating how to select the most relevant antigens and build-up a prognostic scoring system by weighing each antigen according to its predictive power. Although referred to B-cell chronic lymphocytic leukemia, the methodology discussed here can be also useful in the study of diseases other than B-cell chronic lymphocytic leukemia, when the purpose is to identify novel prognostic determinants

Low-dose radiotherapy in diffuse large B-cell lymphoma

Low-dose radiotherapy (LDRT) given in 2 x 2 Gy is a highly effective and safe treatment for palliation of indolent lymphomas. Otherwise, very little regarding the use of LDRT for diffuse large B-cell lymphoma (DLBCL) has been investigated. We designed a phase 2 trial of LDRT in patients with DLBCL with indication for palliative radiation. Low-dose radiotherapy was administered on symptomatic areas only. Clinical response was assessed 21 days after LDRT and defined as reduction >50% of maximum diameter of the radiated lesions. Quality of life was scored by the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire. Tumor subtype (germinal center B-cell type versus activated B-cell type) and the presence of TP53 mutations in pathologic specimens of the target lesion were also evaluated. Twenty-three of twentyfive radiated patients were evaluable for response. and 2 died of disease before the visit at 21 days. The overall response rate was 70% (16 of 23 patients), with 7 complete responses and 9 partial responses (mean duration of response. 6 months; range, 1-39 months). Fifteen patients answered to the QLQ-C30 questionnaires, and an improved quality of life was documented in 9 cases. TP53 mutations were detected in 2 of 6 (33%) nonresponders and in none of the responders (P = .12). Germinal center B-cell type responded better than activated B-cell type (response rate was 83% and 29%, respectively, P = .01). These findings indicate that LDRT is effective for palliation in patients with DLBC

Ca' Foscari Japanese Studies 7, Arts and Literature 2, Rethinking Nature in Japan from Tradition to Modernity

It is a pleasure for us to present this book, with the contributions of the Inter- national Symposium Rethinking Nature in Japan: from Tradition to Modernity held at Ca’ Foscari University of Venice in the Auditorium Santa Margherita. This was the Second International Conference organized in Venice: in 2013 we celebrated the first Symposium Rethinking Nature in Contemporary Japan. Science, Economics, Politics, published by Edizioni Cafoscari in 2014. The aim of the Symposium was the analysis of Japanese society and the international relationships after the accident at Fukushima nuclear plant in March 2011. Its wide-ranging consequences on everyday life of Japanese citizens brought into the limelight issues such as the protection of the environment, the man- agement of natural resources, and food safety, both within the country and abroad, as fundamental challenges to our globalised society. In 2013, the participation of scholars from Europe, Japan and United States helped us to achieve a deeper insight into this multifaceted issue, combining several disciplines under a multidisciplinary and comparative approach. At the root of all these problems stand the basic theme of the relation between man and nature. Historically, Japan has developed through the centuries an extremely rich tradition on this complex topic, in the intel- lectual field as well as in terms of material culture. That is the reason why we decided to choose as the theme of this Sym- posium in 2014 the cultural representations of the idea of Nature in the transition from tradition to modernity. This Symposium, “Rethinking Nature in Japan: From Tradition to Mo- dernity”, was centered on Fine Arts, Religion and Thought, Literature, Theatre and Cinema. We had four panel sessions: “Nature and Environment in Japanese Fine Arts: from Tradition to Modernity”, in Japanese Literature, in Japanese Thought and in Performing Arts. First of all, as a representative of Ca’ Foscari University and of our colleagues, we would like to thank all students, guests and colleagues for their presence at the Symposium, and thank also our special guests from Japan, from the United State, from Europe and from Italy for their (pre- cious) contributions. We believe for all the participants [students, scholars, lecturers, for you and for us] our Symposium was very interesting and fruitful and we hope that the same will be also for this book We would like to thank the representatives of our University, the Rector of Ca’ Foscari University, prof. Carlo Carraro and prof. Tiziana Lippiello, Director of the Department of Asian and North African Studies for their constant support. We are much indebeted to the Director Matsunaga Fumio and to the Japan Foundation for their special attention to the Japanese Studies Sec- tion of our Department. As for our sponsors, we would like to express our thanks to SAGA [School of Asian Studies and Business Management] for the generous financial support. We are also grateful to the artist Miyayama Hiroaki who painted the wisteria branch in the poster of the program and generously allowed us to use it as the logo of our Symposium, and prof. Caterina Virdis Limentani of Padua University who organized the exhibition: Splendori dal Giappone, Le storie del principe Genji nella tradizione Edo e nelle incisioni di Miyayama Hiroaki and the relation between this work and Miyayama’s prints in Padua at Palazzo Zuckermann from March 1st to 31st, 2014. Last but not least, we would thank again all the students who attended the Symposium, the speakers/contributors from Japan, United State, Eu- rope, Italy, the student staff, all our colleagues of the Japanese Section, our young researchers, the organizing committee: Paolo Calvetti, Massimo Raveri, Luisa Bienati, Aldo Tollini, Marcella Mariotti, Giovanni Bulian, Ca- terina Mazza, Toshio Miyake, Andrea Revelant and Pierantonio Zanotti, to all the administration st

Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells

<p>Abstract</p> <p>Background</p> <p>ZAP-70 is an independent negative prognostic marker in chronic lymphocytic leukemia (CLL). Usually, its expression is investigated by flow cytometric protocols in which the percentage of ZAP-70 positive CLL cells is determined in respect to isotypic control (ISO-method) or residual ZAP-70 positive T cells (T-method). These methods, however, beside suffering of an inherent subjectivity in their application, may give discordant results in some cases. The aim of this study was to assess the prognostic significance of these methods in comparison with another in which ZAP-70 expression was evaluated as a Mean-Fluorescence-Intensity Ratio between gated T and CLL cells (T/B Ratio-method).</p> <p>Methods</p> <p>Cytometric files relative to ZAP-70 determination according to the three readouts were retrospectively reviewed on a cohort of 173 patients (test set), all with complete clinical and biological prognostic assessment and time-to-treatment (TTT) available. Findings were then validated in an independent cohort of 341 cases from a different institution (validation set).</p> <p>Results</p> <p>The optimal prognostic cut-offs for ZAP-70 expression were selected at 11% (ISO-method) or 20% of positive cells (T-method), as well as at 3.0 (T/B Ratio-method) in the test set; these cut-offs yielded 66, 60 and 73 ZAP-70⁺cases, respectively. Univariate analyses resulted in a better separation of ZAP-70⁺vs. ZAP-70^-CLL patients utilizing the T/B Ratio, compared to T- or ISO-methods. In multivariate analyses which included the major clinical and biological prognostic markers for CLL, the prognostic impact of ZAP-70 appeared stronger when the T/B-Ratio method was applied. These findings were confirmed in the validation set, in which ZAP-70 expression, evaluated by the T- (cut-off = 20%) or T/B Ratio- (cut-off = 3.0) methods, yielded 180 or 127 ZAP-70⁺cases, respectively. ZAP-70⁺patients according to the T/B Ratio-method had shorter TTT, both if compared to ZAP-70^-CLL, and to cases classified ZAP-70⁺by the T-method only.</p> <p>Conclusions</p> <p>We suggest to evaluate ZAP-70 expression in routine settings using the T/B Ratio-method, given the operator and laboratory independent feature of this approach. We propose the 3.0 T/B Ratio value as optimal cut-off to discriminate ZAP-70⁺(T/B Ratio less than 3.0) from ZAP-70^-(T/B Ratio more/equal than 3.0) cases.</p

CD49d Is the strongest flow cytometry–based predictor of overall survival in chronic lymphocytic leukemia

Purpose Although CD49d is an unfavorable prognostic marker in chronic lymphocytic leukemia (CLL), definitive validation evidence is lacking. A worldwide multicenter analysis was performed using published and unpublished CLL series to evaluate the impact of CD49d as an overall (OS) and treatment-free survival (TFS) predictor. Patients and Methods A training/validation strategy was chosen to find the optimal CD49d cutoff. The hazard ratio (HR) for death and treatment imposed by CD49d was estimated by pooled analysis of 2,972 CLLs; Cox analysis stratified by center and stage was used to adjust for confounding variables. The importance of CD49d over other flow cytometry–based prognosticators (eg, CD38, ZAP-70) was ranked by recursive partitioning. Results Patients with ≥ 30% of neoplastic cells expressing CD49d were considered CD49d+. Decrease in OS at 5 and 10 years among CD49d+ patients was 7% and 23% (decrease in TFS, 26% and 25%, respectively). Pooled HR of CD49d for OS was 2.5 (2.3 for TFS) in univariate analysis. This HR remained significant and of similar magnitude (HR, 2.0) in a Cox model adjusted for clinical and biologic prognosticators. Hierarchic trees including all patients or restricted to those with early-stage disease or those age ≤ 65 years always selected CD49d as the most important flow cytometry–based biomarker, with negligible additional prognostic information added by CD38 or ZAP-70. Consistently, by bivariate analysis, CD49d reliably identified patient subsets with poorer outcome independent of CD38 and ZAP-70. Conclusion In this analysis of approximately 3,000 patients, CD49d emerged as the strongest flow cytometry–based predictor of OS and TFS in CLL